Papers

Peer-reviewed
May 25, 2011

The possibility of detecting natural selection in pigmentation candidate genes from haplotype structure as revealed by SNP analysis

Japanese Journal of Physiological Anthropology
  • Sumiko Anno
  • ,
  • Kazuhiko Ohshima
  • ,
  • Takashi Abe

Volume
16
Number
2
First page
99
Last page
102
Language
Japanese
Publishing type
Research paper (scientific journal)
DOI
10.20718/jjpa.16.2_99
Publisher
Japan Society of Physiological Anthropology

Detecting natural selection would provide valuable insight into the molecular mechanisms of pathogenesis and advanced knowledge about the history of human adaptations to local environments. This study tried to detect natural selection in pigmentation candidate genes from haplotype structure as revealed by SNP analyses. We estimated the frequencies of diplotypes (combinations of the haplotypes) expected from Hardy-Weinberg equilibrium to evaluate natural selection. We also tested for correlations between the haplotypes with a high frequency and melanin content. The results indicated the possible difference of the melanin contents among the haplotypes. We suggest the possibility of natural selection to a mutation linking to the SNPs in the haplotypes. This paper also discusses future approaches to detecting natural selection in pigmentation candidate genes from haplotype structure as revealed by SNP analyses.

Link information
DOI
https://doi.org/10.20718/jjpa.16.2_99
CiNii Articles
http://ci.nii.ac.jp/naid/110008673769
CiNii Books
http://ci.nii.ac.jp/ncid/AN1052804X
URL
http://search.jamas.or.jp/link/ui/2011267650
ID information
  • DOI : 10.20718/jjpa.16.2_99
  • ISSN : 1342-3215
  • CiNii Articles ID : 110008673769
  • CiNii Books ID : AN1052804X

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