2020年8月
A lipophilic ionic liquid-based dye for anion optodes: importance of dye lipophilicity and application to heparin measurement
ANALYST
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- 巻
- 145
- 号
- 16
- 開始ページ
- 5430
- 終了ページ
- 5437
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1039/d0an00335b
- 出版者・発行元
- ROYAL SOC CHEMISTRY
Herein, a fully lipophilic ionic liquid (IL) comprising a lipophilic fluorescein anion and a trihexyltetradecylphosphonium cation was synthesized and used as the plasticizer for a plasticized poly(vinyl chloride) (PVC) membrane optode. Systematic investigation of the alkyl chain length of the fluorescein anion proved the significance of lipophilicity for obtaining the reversible absorbance measurements. A PVC membrane fabricated with the synthesized lipophilic IL was observed to comprise an unusually high dye concentration (915 mmol kg(-1)) and exhibited good sensitivity as well as response time in its sensor performance. The sensitivity of the presented PVC membrane was 26-fold higher than that of a conventional optode membrane with the same membrane thickness and the same lipophilic dye of typical dye content (1 wt%). The response time was observed to be >120-fold faster by using a significantly thinner PVC membrane (approx. 140 nm). Heparin is known to be a polyanionic anticoagulant, and the presented PVC membrane exhibited an extremely fast response (20-150 seconds) to the heparin in diluted serum within the required concentration region. Thus, the lipophilic IL-based dye could significantly improve the sensor performance in conventional optodes, especially for an analyte showing slow diffusion, such as macromolecular heparin.
- リンク情報
- ID情報
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- DOI : 10.1039/d0an00335b
- ISSN : 0003-2654
- eISSN : 1364-5528
- PubMed ID : 32662452
- Web of Science ID : WOS:000558067300035