Teruyoshi Hirayama - My portal

Profile Information

Affiliation: The University of Tokushima

J-GLOBAL ID: 201801007056122608
researchmap Member ID: B000343215

Research Interests

Research Areas

Research History

Apr, 2018 - Present

The University of Tokushima
Apr, 2015 - Mar, 2018

Graduate School of Frontier Biosciences, Osaka University
Oct, 2011 - Mar, 2015

Graduate School of Frontier Biosciences, Osaka University
Apr, 2006 - Sep, 2011

Graduate School of Frontier Biosciences, Osaka University
Apr, 2002 - Mar, 2006

CREST研究員, 戦略的創造研究推進事業, 科学技術振興機構

Papers

Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality

Hiroaki Kobayashi, Kenji Takemoto, Makoto Sanbo, Masumi Hirabayashi, Takahiro Hirabayashi, Teruyoshi Hirayama, Hiroshi Kiyonari, Takaya Abe, Takeshi Yagi

iScience, 26(1) 105766-105766, Jan, 2023 Peer-reviewed
CTCF loss induces giant lamellar bodies in Purkinje cell dendrites.

Teruyoshi Hirayama, Yuuki Kadooka, Etsuko Tarusawa, Sei Saitoh, Hisako Nakayama, Natsumi Hoshino, Soichiro Nakama, Takahiro Fukuishi, Yudai Kawanishi, Hiroki Umeshima …

Acta neuropathologica communications, 10(1) 172-172, Nov 29, 2022 Peer-reviewed
Pcdhβ deficiency affects hippocampal CA1 ensemble activity and contextual fear discrimination

Hirotaka Asai, Noriaki Ohkawa, Yoshito Saitoh, Khaled Ghandour, Emi Murayama, Hirofumi Nishizono, Mina Matsuo, Teruyoshi Hirayama, Ryosuke Kaneko, Shin-ichi Muramatsu …

Molecular Brain, 13(1) 7-7, Dec, 2020 Peer-reviewed
Suppression of DNA Double-Strand Break Formation by DNA Polymerase β in Active DNA Demethylation Is Required for Development of Hippocampal Pyramidal Neurons

Akiko Uyeda, Kohei Onishi, Teruyoshi Hirayama, Satoko Hattori, Tsuyoshi Miyakawa, Takeshi Yagi, Nobuhiko Yamamoto, Noriyuki Sugo

The Journal of Neuroscience, 40(47) 9012-9027, Nov 18, 2020 Peer-reviewed
Snf2h Drives Chromatin Remodeling to Prime Upper Layer Cortical Neuron Development

Matías Alvarez-Saavedra, Keqin Yan, Yves De Repentigny, Lukas E. Hashem, Nidhi Chaudary, Shihab Sarwar, Doo Yang, Ilya Ioshikhes, Rashmi Kothary, Teruyoshi Hirayama …

Frontiers in Molecular Neuroscience, 12 243-243, Oct 17, 2019 Peer-reviewed
Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell–derived cortical interneurons from subjects with schizophrenia

Zhicheng Shao, Haneul Noh, Woong Bin Kim, Peiyan Ni, Christine Nguyen, Sarah E. Cote, Elizabeth Noyes, Joyce Zhao, Teagan Parsons, James M. Park …

Nature Neuroscience, 22(2) 229-242, Feb, 2019 Peer-reviewed
Regulation of clustered protocadherin genes in individual neurons

Teruyoshi Hirayama, Takeshi Yagi

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 69 122-130, Sep, 2017 Peer-reviewed
The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain

Yan Jiang, Yong-Hwee Eddie Loh, Prashanth Rajarajan, Teruyoshi Hirayama, Will Liao, Bibi S. Kassim, Behnam Javidfar, Brigham J. Hartley, Lisa Kleofas, Royce B. Park …

NATURE GENETICS, 49(8) 1239-+, Aug, 2017 Peer-reviewed
Genome Stability by DNA Polymerase beta in Neural Progenitors Contributes to Neuronal Differentiation in Cortical Development

Kohei Onishi, Akiko Uyeda, Mitsuhiro Shida, Teruyoshi Hirayama, Takeshi Yagi, Nobuhiko Yamamoto, Noriyuki Sugo

JOURNAL OF NEUROSCIENCE, 37(35) 8444-8458, Aug, 2017 Peer-reviewed
Establishment of high reciprocal connectivity between clonal cortical neurons is regulated by the Dnmt3b DNA methyltransferase and clustered protocadherins

Etsuko Tarusawa, Makoto Sanbo, Atsushi Okayama, Toshio Miyashita, Takashi Kitsukawa, Teruyoshi Hirayama, Takahiro Hirabayashi, Sonoko Hasegawa, Ryosuke Kaneko, Shunsuke Toyoda …

BMC BIOLOGY, 14(1) 103, Dec, 2016 Peer-reviewed
Distinct and Cooperative Functions for the Protocadherin-alpha,-beta and-gamma Clustersin Neuronal Survival and Axon Targeting

Sonoko Hasegawa, Makiko Kumagai, Mitsue Hagihara, Hiroshi Nishimaru, Keizo Hirano, Ryosuke Kaneko, Atsushi Okayama, Teruyoshi Hirayama, Makoto Sanbo, Masumi Hirabayashi …

FRONTIERS IN MOLECULAR NEUROSCIENCE, 9 155, Dec, 2016 Peer-reviewed
Developmental Epigenetic Modification Regulates Stochastic Expression of Clustered Protocadherin Genes, Generating Single Neuron Diversity

Shunsuke Toyoda, Masahumi Kawaguchi, Toshihiro Kobayashi, Etsuko Tarusawa, Tomoko Toyama, Masaki Okano, Masaaki Oda, Hiromitsu Nakauchi, Yumiko Yoshimura, Makoto Sanbo …

NEURON, 82(1) 94-108, Apr, 2014 Peer-reviewed
Clustered Protocadherins and Neuronal Diversity

Teruyoshi Hirayama, Takeshi Yagi

MOLECULAR BIOLOGY OF CADHERINS, 116 145-167, 2013 Peer-reviewed
CTCF Is Required for Neural Development and Stochastic Expression of Clustered Pcdh Genes in Neurons

Teruyoshi Hirayama, Etsuko Tarusawa, Yumiko Yoshimura, Niels Galjart, Takeshi Yagi

CELL REPORTS, 2(2) 345-357, Aug, 2012 Peer-reviewed
Identification of the Cluster Control Region for the Protocadherin-beta Genes Located beyond the Protocadherin-gamma Cluster

Shinnichi Yokota, Teruyoshi Hirayama, Keizo Hirano, Ryosuke Kaneko, Shunsuke Toyoda, Yoshimi Kawamura, Masumi Hirabayashi, Takahiro Hirabayashi, Takeshi Yagi

JOURNAL OF BIOLOGICAL CHEMISTRY, 286(36) 31885-31895, Sep, 2011 Peer-reviewed
Relationship between DNA methylation states and transcription of individual isoforms encoded by the protocadherin-alpha gene cluster

Masahumi Kawaguchi, Tomoko Toyama, Ryosuke Kaneko, Teruyoshi Hirayama, Yoshimi Kawamura, Takeshi Yagi

JOURNAL OF BIOLOGICAL CHEMISTRY, 283(18) 12064-12075, May, 2008 Peer-reviewed
[Clustered protocadherin family].

Hirayama T, Hasegawa S, Yagi T

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 53(4 Suppl) 358-364, Mar, 2008
Allelic gene regulation of Pcdh-alpha and Pcdh-gamma clusters involving both monoallelic and biallelic expression in single Purkinje cells

Ryosuke Kaneko, Hiroyuki Kato, Yoshimi Kawamura, Shigeyuki Esumi, Teruyoshi Hirayama, Takahiro Hirabayashi, Takeshi Yagi

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(41) 30551-30560, Oct, 2006 Peer-reviewed
The role and expression of the protocadherin-alpha clusters in the CNS

Teruyoshi Hirayama, Takeshi Yagi

CURRENT OPINION IN NEUROBIOLOGY, 16(3) 336-342, Jun, 2006 Peer-reviewed
Evaluation of somatic alterations of Pcdh-alpha transcripts in the brain by cDNA analysis without PCR

T Hirayama, A Sasaki, T Yagi

GENES TO CELLS, 11(1) 95-97, Jan, 2006 Peer-reviewed

Misc.

脳の獲得的性質を支える分子メカニズムの探索--CNR/プロトカドヘリンファミリーの遺伝子構造と機能

平山晃斉, 杉野英彦, 八木健

蛋白質核酸酵素, 46(6) 698-705, May, 2001

Books and Other Publications

Clustered Protocadherins and Neuronal Diversity

Hirayama T, Yagi T (Role: Joint author, Vol. 116. pp.145-167.)

Elsevier Academic Press, 2013
クラスター型プロトカドヘリンファミリー；多様性創出機構とその機能解明に向けて

平山晃斉, 長谷川園子, 八木健 (Role: Joint author, 蛋白質核酸酵素 53、358-364)

共立出版, 2008
脳の獲得的性質を支える分子メカニズムの探索 CNR／プロトカドヘリンファミリーの遺伝子構造と機能

平山晃斉, 杉野英彦, 八木健 (Role: Joint author, 蛋白質核酸酵素 46、 698-705)

共立出版, 2001

Research Projects

高次染色体構造の形成異常に起因する神経機能障害

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

平山晃斉
Molecular basis of functional neural circuits of excitatory and inhibitory neurons in the cerebral cortex

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2022

HIRAYAMA Teruyoshi
The role of neuronal diversity in the neural circuit of somatosensory cortex

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

HIRAYAMA Teruyoshi
染色体高次構造の変換による多様な神経細胞の産生

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2013 - Mar, 2015

平山晃斉
Functional analysis of CTCF for generating neuronal diversity and neuronal networks

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

HIRAYAMA Teruyoshi
Analysis of gene regulation for neuronal cell identity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2007 - 2008

HIRAYAMA Teruyoshi