野阪拓人 (Takuto NOSAKA) - マイポータル

基本情報

所属: 福井大学医学系部門医学領域（附属病院部）消化器内科准教授

学位: 医学博士(2018年3月福井大学)

研究者番号: 70748441
ORCID iD: https://orcid.org/0000-0002-1929-7305
J-GLOBAL ID: 201801000708008808
researchmap会員ID: B000318121

研究キーワード

研究分野

経歴

2026年4月 - 現在

福井大学大学院医学系研究科消化器内科学, 准教授
2024年4月 - 2026年3月

福井大学大学院医学系研究科, 内科学(２)分野, 講師
2019年3月 - 2024年3月

福井大学大学院医学系研究科, 内科学(２)分野, 助教
2018年4月 - 2019年3月

福井大学医学部附属病院, 光学医療診療部, 助教
2015年4月 - 2017年3月

金沢大学がん進展制御研究所, 分子生体応答分野, 特別研究員
2012年4月 - 2015年3月

福井大学大学院医学系研究科, 内科学(２)分野, 医員
2010年4月 - 2012年3月

福井大学医学部附属病院, 初期臨床研修医

学歴

2004年4月 - 2010年3月

福井大学, 医学部, 医学科

受賞

2025年11月

優秀演題賞, 第67回日本消化器病学会大会（JDDW）

野阪拓人
2024年11月

優秀演題賞, 第66回日本消化器関連学会機構（JDDW)

野阪拓人
2024年9月

Presidential Award, The Asian Pacific Association for the Study of the Liver (APASL) Oncology 2024

Takuto Nosaka
2023年11月

The Best Presenter Award in International Session, 日本消化器関連学会機構（JDDW)

Takuto Nosaka
2022年11月

Posters of Distinction, American Association for the Study of Liver Diseases (AASLD) Annual Meeting 2022

Takuto Nosaka
2020年11月

Early Career Investigator Award in Basic Science, American Association for the Study of Liver Diseases (AASLD) Annual Meeting 2020

Takuto Nosaka
2020年11月

若手奨励賞, 日本消化器関連学会機構（JDDW)

野阪拓人
2018年11月

学術奨励賞銀賞, 福井大学医学部同窓会白翁会

野阪拓人
2017年10月

Basic Science Young Investigator Travel Award, 米国肝臓病学会

野阪拓人

主要な論文

108

Spatial Proximity Between PD-L1(+) Tumor-Associated Macrophages and CD8(+) T Cells Influences Response to Atezolizumab Plus Bevacizumab in Hepatocellular Carcinoma

Takuto Nosaka, Masahiro Ohtani, Junki Yamashita, Yosuke Murata, Yu Akazawa, Tomoko Tanaka, Kazuto Takahashi, Tatsushi Naito, Yoshiaki Imamura, Kenji Koneri …

Cancers 2026年4月29日
PD-L1(+) tumor-associated macrophages induce CD8(+) T Cell exhaustion in hepatocellular carcinoma.

Takuto Nosaka, Masahiro Ohtani, Junki Yamashita, Yosuke Murata, Yu Akazawa, Tomoko Tanaka, Kazuto Takahashi, Tatsushi Naito, Yoshiaki Imamura, Kenji Koneri …

Neoplasia (New York, N.Y.) 69 101234-101234 2025年11月
Proton Beam Therapy Provides Longer Survival and Preserves Muscle Mass in Hepatocellular Carcinoma Compared to TACE+RFA

Takuto Nosaka, Ryotaro Sugata, Yosuke Murata, Yu Akazawa, Tomoko Tanaka, Kazuto Takahashi, Tatsushi Naito, Masahiro Ohtani, Kenji Takata, Tetsuya Tsujikawa …

Cancers 17(17) 2025年8月
Clinical Significance of CD90(+) Circulating Tumor Cells as Dynamic Biomarkers in Unresectable Hepatocellular Carcinoma Treated with Atezolizumab/Bevacizumab and Lenvatinib

Takuto Nosaka, Yosuke Murata, Yu Akazawa, Tomoko Tanaka, Kazuto Takahashi, Tatsushi Naito, Masahiro Ohtani, Yasunari Nakamoto

Cancers 17(17) 2025年8月
Identification of novel antiviral host factors by functional gene expression analysis using in vitro HBV infection assay systems

Takuto Nosaka, Tatsushi Naito, Yu Akazawa, Kazuto Takahashi, Hidetaka Matsuda, Masahiro Ohtani, Tsutomu Nishizawa, Hiroaki Okamoto, Yasunari Nakamoto

PLOS ONE 20(3) e0314581-e0314581 2025年3月6日
Changes of circulating tumor cells expressing CD90 and EpCAM in early-phase of atezolizumab and bevacizumab for hepatocellular carcinoma.

Takuto Nosaka, Yosuke Murata, Yu Akazawa, Kazuto Takahashi, Tatsushi Naito, Hidetaka Matsuda, Masahiro Ohtani, Yasunari Nakamoto

Heliyon 10(14) e34441 2024年7月30日査読有り
Serial Changes of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma Treated with Atezolizumab Plus Bevacizumab.

Yosuke Murata, Takuto Nosaka, Yu Akazawa, Tomoko Tanaka, Kazuto Takahashi, Tatsushi Naito, Hidetaka Matsuda, Masahiro Ohtani, Yasunari Nakamoto

Cancers 16(13) 2024年6月29日査読有り
Programmed Death Ligand 1 Expression in Circulating Tumor Cells as a Predictor and Monitor of Response to Atezolizumab plus Bevacizumab Treatment in Patients with Hepatocellular Carcinoma

Takuto Nosaka, Yosuke Murata, Yu Akazawa, Tomoko Tanaka, Kazuto Takahashi, Tatsushi Naito, Hidetaka Matsuda, Masahiro Ohtani, Yoshiaki Imamura, Yasunari Nakamoto

Cancers 16(9) 2024年5月査読有り
Isolation of mucosa-associated microbiota dysbiosis in the ascending colon in hepatitis C virus post-sustained virologic response cirrhotic patients.

Yohei Midori, Takuto Nosaka, Katsushi Hiramatsu, Yu Akazawa, Tomoko Tanaka, Kazuto Takahashi, Tatsushi Naito, Hidetaka Matsuda, Masahiro Ohtani, Yasunari Nakamoto

Frontiers in cellular and infection microbiology 14 1371429-1371429 2024年査読有り
Hepatocellular carcinoma progression promoted by 5-lipoxygenase activity in CD163(+) tumor-associated macrophages.

Takuto Nosaka, Yosuke Murata, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Yoshiaki Imamura, Takanori Goi …

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 162 114592-114592 2023年6月査読有り
High correlation of hepatic shear wave velocity with esophageal varices complication rate in patients with chronic liver diseases.

Shouichi Namikawa, Takuto Nosaka, Hidetaka Matsuda, Yu Akazawa, Kazuto Takahashi, Tatsushi Naito, Masahiro Ohtani, Yasunari Nakamoto

BMC gastroenterology 23(1) 169-169 2023年5月22日査読有り
Longer Survival and Preserved Liver Function after Proton Beam Therapy for Patients with Unresectable Hepatocellular Carcinoma.

Takuto Nosaka, Hidetaka Matsuda, Ryotaro Sugata, Yu Akazawa, Kazuto Takahashi, Tatsushi Naito, Masahiro Ohtani, Kazuyuki Kinoshita, Tetsuya Tsujikawa, Yoshitaka Sato …

Current oncology (Toronto, Ont.) 30(4) 3915-3926 2023年3月30日査読有り
Regulatory function of interferon-inducible 44-like for hepatitis B virus covalently closed circular DNA in primary human hepatocytes.

Takuto Nosaka, Tatsushi Naito, Yosuke Murata, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Tsutomu Nishizawa, Hiroaki Okamoto, Yasunari Nakamoto

Hepatology research : the official journal of the Japan Society of Hepatology 52(2) 141-152 2021年10月25日
Clinical Usefulness of [18F]-Fluoro-2-Deoxy-d-Glucose-Positron Emission Tomography/Computed Tomography for Distinguishing Between Autoimmune Pancreatitis and Pancreatic Cancer.

Masahiro Ohtani, Kazuya Ofuji, Yu Akazawa, Yasushi Saito, Takuto Nosaka, Yoshihiko Ozaki, Kazuto Takahashi, Tatsushi Naito, Hidetaka Matsuda, Katsushi Hiramatsu …

Pancreas 50(7) 1014-1019 2021年8月1日査読有り
Advanced primary adenosquamous carcinoma of the liver with a small cell carcinoma component: an autopsy case report.

Takuto Nosaka, Masahiro Ohtani, Shouichi Namikawa, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Katsushi Hiramatsu, Yoshiaki Imamura, Yasunari Nakamoto

Clinical journal of gastroenterology 14(5) 1496-1502 2021年7月3日査読有り
【免疫チェックポイント阻害薬と分子標的薬による肝障害】免疫チェックポイント阻害薬による肝障害リスク因子

大藤和也, 野阪拓人, 中本安成

肝臓 61(3) 95-96 2020年3月
Molecular signature of hepatitis B virus regulation by interferon-γ in primary human hepatocytes.

Takuto Nosaka, Tatsushi Naito, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Tomoyuki Nemoto, Tsutomu Nishizawa, Hiroaki Okamoto, Yasunari Nakamoto

Hepatology research : the official journal of the Japan Society of Hepatology 50(3) 292-302 2020年3月査読有り
Daily Usage of Proton Pump Inhibitors May Reduce the Severity of Critical Upper Gastrointestinal Bleeding in Elderly Patients.

Hidetaka Matsuda, Takuto Nosaka, Yu Akazawa, Yasushi Saito, Yoshihiko Ozaki, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Masahiro Ohtani, Katsushi Hiramatsu …

Gastroenterology research and practice 2020 7168621-7168621 2020年査読有り
Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells.

Naofumi Mukaida, Takuto Nosaka, Yasunari Nakamoto, Tomohisa Baba

International journal of molecular sciences 20(1) 2018年12月29日査読有り
Long-term prognosis after biliary stenting for common bile duct stones in high-risk elderly patients.

Yu Akazawa, Masahiro Ohtani, Takuto Nosaka, Yasushi Saito, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Katsushi Hiramatsu, Tomoyuki Nemoto …

Journal of digestive diseases 19(10) 626-634 2018年10月査読有り
Genetic polymorphism and decreased expression of HLA class II DP genes are associated with HBV reactivation in patients treated with immunomodulatory agents.

Hidetaka Matsuda, Katsushi Hiramatsu, Yu Akazawa, Takuto Nosaka, Yasushi Saito, Yoshihiko Ozaki, Ryoko Hayama, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji …

Journal of medical virology 90(4) 712-720 2018年4月査読有り
Alveolar Macrophages Drive Hepatocellular Carcinoma Lung Metastasis by Generating Leukotriene B4.

Takuto Nosaka, Tomohisa Baba, Yamato Tanabe, Soichiro Sasaki, Tatsunori Nishimura, Yoshiaki Imamura, Hideaki Yurino, Shinichi Hashimoto, Makoto Arita, Yasunari Nakamoto …

Journal of immunology (Baltimore, Md. : 1950) 200(5) 1839-1852 2018年3月1日査読有り
Identification of novel variants in HLA class II region related to HLA DPB1 expression and disease progression in patients with chronic hepatitis C.

Katsushi Hiramatsu, Hidetaka Matsuda, Tomoyuki Nemoto, Takuto Nosaka, Yasushi Saito, Tatsushi Naito, Kazuto Takahashi, Kazuya Ofuji, Masahiro Ohtani, Hiroyuki Suto …

Journal of medical virology 89(9) 1574-1583 2017年9月査読有り
Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B.

Takuto Nosaka, Tatsushi Naito, Katsushi Hiramatsu, Masahiro Ohtani, Tomoyuki Nemoto, Hiroyuki Marusawa, Ning Ma, Yusuke Hiraku, Shosuke Kawanishi, Taro Yamashita …

PloS one 12(10) e0185442 2017年査読有り
Ruptured hepatic metastases of cutaneous melanoma during treatment with vemurafenib: an autopsy case report.

Takuto Nosaka, Katsushi Hiramatsu, Tomoyuki Nemoto, Yasushi Saito, Yoshihiko Ozaki, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani …

BMC clinical pathology 15(1) 15-15 2015年査読有り
A case of superficial esophageal basaloid squamous cell carcinoma resected by endoscopic submucosal dissection

Takuto Nosaka, Hiroyuki Suto, Hidetaka Matsuda, Kazuto Takahashi, Masahiro Ohtani, Katsushi Hiramatsu, Tomoyuki Nemoto, Yoshiaki Imamura, Yasunari Nakamoto

Journal of Japanese Society of Gastroenterology 111(6) 1105-1112 2014年査読有り