論文

国際誌
2021年7月18日

Altered serum soluble furin and prorenin receptor levels in pregnancies with pre-eclampsia and fetal growth restriction.

Journal of gynecology obstetrics and human reproduction
  • Akiko Ohwaki
  • ,
  • Haruki Nishizawa
  • ,
  • Asuka Kato
  • ,
  • Hikari Yoshizawa
  • ,
  • Jun Miyazaki
  • ,
  • Yoshiteru Noda
  • ,
  • Yoshiko Sakabe
  • ,
  • Takao Sekiya
  • ,
  • Takuma Fujii
  • ,
  • Hiroki Kurahashi

50
10
開始ページ
102198
終了ページ
102198
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jogoh.2021.102198

OBJECTIVE: The proprotein convertase furin is known to be involved in the processing of pro-B-type natriuretic peptide (proBNP) and prorenin receptor (PRR), suggesting that it has a potential function in blood pressure regulation. We investigated the role of furin in the etiology of pre-eclampsia and its related disorder, unexplained fetal growth restriction (FGR) without hypertension. METHODS: We evaluated serum and placental furin levels in pre-eclampsia, FGR and uncomplicated pregnancy. Additionally, we investigated the correlation between the serum furin levels and products of furin enzymatic activity or clinical parameters. RESULTS: We demonstrated that the maternal circulation in cases of pre-eclampsia and FGR had lower levels of soluble furin than uncomplicated pregnancies. Both NT-proBNP and soluble PRR were elevated in pre-eclampsia, whereas only soluble PRR was at higher levels in unexplained FGR. Linear regression analysis revealed a negative correlation between the serum furin level and that of NT-proBNP or soluble PRR. While we observed that the serum furin or soluble PRR level correlated with blood pressure, a stronger correlation was observed with birth and placental weights. Further to this, the FURIN mRNA levels were significantly reduced in placental pre-eclamptic placentas as well as in FGR cases. CONCLUSION: These data suggest the possibility that reduced levels of furin may be the result of a negative feedback from the activation of the renin-angiotensin pathway that leads to feto-placental dysfunction with or without maternal hypertension. This may represent an etiologic pathway of pre-eclampsia and unexplained FGR.

リンク情報
DOI
https://doi.org/10.1016/j.jogoh.2021.102198
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34289413
ID情報
  • DOI : 10.1016/j.jogoh.2021.102198
  • PubMed ID : 34289413

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