2016年7月
Iridium-Catalyzed Intramolecular Methoxy C-H Addition to Carbon-Carbon Triple Bonds: Direct Synthesis of 3-Substituted Benzofurans from o-Methoxyphenylalkynes
CHEMISTRY-A EUROPEAN JOURNAL
- ,
- ,
- 巻
- 22
- 号
- 30
- 開始ページ
- 10415
- 終了ページ
- 10419
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/chem.201602152
- 出版者・発行元
- WILEY-V C H VERLAG GMBH
Catalytic hydroalkylation of an alkyne with methyl ether was accomplished. Intramolecular addition of the C-H bond of a methoxy group in 1-methoxy-2-(arylethynyl)benzenes across a carbon-carbon triple bond took place efficiently either in toluene at 110 degrees C or in p-xylene at 135 degrees C in the presence of an iridium catalyst. The initial 5-exo cyclization products underwent double-bond migration during the reaction to give 3-(arylmethyl)benzofurans in high yields.
- リンク情報
- ID情報
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- DOI : 10.1002/chem.201602152
- ISSN : 0947-6539
- eISSN : 1521-3765
- Web of Science ID : WOS:000380273300022