Takayuki KOGA

Profile Information

Affiliation: Daiichi University,College of Pharmaceutical Sciences

Degree: 博士（薬学）(九州大学)

Researcher number: 80733279
J-GLOBAL ID: 201801000760266777
researchmap Member ID: B000324993

Research Interests

Research Areas

Research History

Apr, 2022 - Present

Daiichi University, College of Pharmaceutical Sciences
Apr, 2014 - Mar, 2022

Assistant professor, hygienic chemistry, Daiichi university of pharmacy
Jun, 2012 - Mar, 2014

Postdoctoral fellow, the center of molecular toxicology and carcinogenesis, Pennsylvania State university
Apr, 2012 - Jun, 2012

research associate, the laboratory of molecular life sciences, kyushu university

Education

Apr, 2009 - Mar, 2012

Kyushu university

Awards

Oct, 2011

Excellent Young Investigator Award, The Pharmaceutial Society of Japan, Division of pharmaceutical health sciences and environmental toxicology

Takayuki KOGA
Dec, 2008

Best presentation award, The Pharmaceutial Society of Japan, kyushu branch

Takayuki KOGA

Papers

Dimethylglycine, a methionine metabolite, participates in the suppressive effect of methionine on 1-fluoro-2,4-dinitrobenzene-induced dermatitis.

Takayuki Koga, Kie Inoue, Fuka Hirayama, Makoto Hiromura, Kiyonaga Fujii, Yuji Ishii, Masayo Hirao-Suzuki, Shuso Takeda, Akihisa Toda, Fumio Soeda

Biological & pharmaceutical bulletin, 46(7) 946-954, May 13, 2023
α-Lipoic acid eliminates dioxin-induced offspring sexual immaturity by improving abnormalities in folic acid metabolism.

Ming Yuan, Hiroe Sano, Takaaki Nishino, Hongbin Chen, Ren-Shi Li, Yuki Matsuo, Kyoko Nishida, Takayuki Koga, Tomoki Takeda, Yoshitaka Tanaka …

Biochemical pharmacology, 210 115490-115490, Mar 7, 2023
Cannabidiolic acid activates the expression of the PPARβ/δ target genes in MDA-MB-231 cells

Masayo Hirao-Suzuki, Koga Takayuki, Masufumi Takiguchi, Jeffrey M Peters, Shuso Takeda

Archives of Biochemistry and Biophysics, 731 109428-109428, Nov, 2022 Peer-reviewed
Perfluorooctanoic acid (PFOA) as a stimulator of estrogen receptor-negative breast cancer MDA-MB-231 cell aggressiveness: Evidence for involvement of fatty acid 2-hydroxylase (FA2H) in the stimulated cell migration

Genki Sakai, Masayo Hirao-Suzuki, Takayuki Koga, Takananobu Kobayashi, Jun Kamishikiryo, Michitaka Tanaka, Kiyonaga Fujii, Masufumi Takiguchi, Narumi Sugihara, Akihisa Toda …

The Journal of Toxicological Sciences, 47(4) 159-168, 2022
Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice

Jennifer E Foreman, Takayuki Koga, Oksana Kosyk, Boo-Hyon Kang, Xiaoyang Zhu, Samuel M Cohen, Laura J Billy, Arun K Sharma, Shantu Amin, Frank J Gonzalez …

Toxicological Sciences, 183(1) 70-80, Aug 30, 2021 Peer-reviewed
Species Differences between Mouse and Human PPARα in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARα Agonist in Mice

Jennifer E Foreman, Takayuki Koga, Oksana Kosyk, Boo-Hyon Kang, Xiaoyang Zhu, Samuel M Cohen, Laura J Billy, Arun K Sharma, Shantu Amin, Frank J Gonzalez …

Toxicological Sciences, 183(1) 81-92, Aug 30, 2021 Peer-reviewed
Effects of enriched environment on micturition activity in freely moving C57BL/6J mice.

Fumio Soeda, Akihisa Toda, Kazuya Masuzaki, Risa Miki, Takayuki Koga, Yukiko Fujii, Kazuo Takahama

Lower urinary tract symptoms, 13(3) 400-409, Jul, 2021
Ablation of Selenbp1 Alters Lipid Metabolism via the Pparα Pathway in Mouse Kidney

Yingxia Song, Atsushi Kurose, Renshi Li, Tomoki Takeda, Yuko Onomura, Takayuki Koga, Junpei Mutoh, Takumi Ishida, Yoshitaka Tanaka, Yuji Ishii

International Journal of Molecular Sciences, 22(10) 5334-5334, May 19, 2021
Methionine is a Key Regulator in the Onset of Atopic Dermatitis in NC/Nga Mice

Takayuki Koga, Fuka Hirayama, Tomomitsu Satoh, Yuji Ishii, Nobuhiro Kashige, Makoto Hiromura, Fumio Soeda, Akihisa Toda

BPB Reports, 4(1) 47-54, 2021 Peer-reviewed
Fatty acid 2-hydroxylase (FA2H) as a stimulatory molecule responsible for breast cancer cell migration.

Masayo Hirao-Suzuki, Takayuki Koga, Genki Sakai, Takanobu Kobayashi, Yuji Ishii, Hiroshi Miyazawa, Masufumi Takiguchi, Narumi Sugihara, Akihisa Toda, Masahiro Ohara …

Biochemical and biophysical research communications, 531(2) 215-222, Oct 15, 2020 Peer-reviewed
Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231 breast cancer cells: Possible implication of the peroxisome proliferator-activated receptor β/δ abrogation

Masayo Hirao-Suzuki, Shuso Takeda, Takayuki Koga, Masufumi Takiguchi, Akihisa Toda

The Journal of Toxicological Sciences, 45(4) 227-236, 2020 Peer-reviewed
雌マウス肝臓におけるセレン結合性タンパク質 (SelenBP)の発現と 2,3,7,8- tetrachlorodibenzo-p-dioxin 被誘導性: SelenBP1 欠損動物を用いた検討

宋穎霞, 藤本景子, 黒瀬厚, 石田卓巳, 古賀貴之, 李任時, 武田知起, 武知進士, 山田英之, 田中嘉孝 …

福岡医学雑誌, 110(2) 128-132, Jun, 2019 Peer-reviewed
Evaluation of methionine supplementation for allergic contact dermatitis.

Takayuki KOGA

34 64-73, Mar, 2018
Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration

Tomoki Takeda, Yukiko Komiya, Takayuki Koga, Takumi Ishida, Yuji Ishii, Yasushi Kikuta, Michio Nakaya, Hitoshi Kurose, Takehiko Yokomizo, Takao Shimizu …

JOURNAL OF BIOLOGICAL CHEMISTRY, 292(25) 10586-10599, Jun, 2017 Peer-reviewed
alpha-Lipoic acid potentially targets AMP-activated protein kinase and energy production in the fetal brain to ameliorate dioxin-produced attenuation in fetal steroidogenesis

Tomoki Takeda, Yuki Matsuo, Kyoko Nishida, Akihisa Fujiki, Yukiko Hattori, Takayuki Koga, Yuji Ishii, Hideyuki Yamada

JOURNAL OF TOXICOLOGICAL SCIENCES, 42(1) 13-23, Feb, 2017 Peer-reviewed
Enhancement and regulation effect of myrcene on antibody response in immunization with ovalbumin and Ag85B in mice

Saori Uyeda, Tanjina Sharmin, Tomomitsu Satho, Keiichi Irie, Mineo Watanabe, Masato Hosokawa, Yukihiro Hiramatsu, Takayuki Koga, Yukihiko Nakashima, Nobuhiro Kashige …

ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, 34(4) 314-321, Dec, 2016 Peer-reviewed
Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-beta/delta Modulation of SP1 Promoter Occupancy

Takayuki Koga, Pei-Li Yao, Maryam Goudarzi, Iain A. Murray, Gayathri Balandaram, Frank J. Gonzalez, Gary H. Perdew, Albert J. Fornace, Jeffrey M. Peters

JOURNAL OF BIOLOGICAL CHEMISTRY, 291(48) 25255-25263, Nov, 2016 Peer-reviewed
Lactobacilli aggravate atopic dermatitis via regulation of hepatic PPARalpha expression.

Takayuki KOGA

Annual report of Daiichi university of pharmacy, 32 28-35, Mar, 2016
Role of the Critical Period in Sex and Brain Differentiation: Learning from Dioxin-induced Disorders in Next Generations

Hideyuki Yamada, Tomoki Takeda, Takayuki Koga, Yuji Ishii

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 134(4) 529-535, Apr, 2014
PPAR beta/delta modulates ethanol-induced hepatic effects by decreasing pyridoxal kinase activity

Maryam Goudarzi, Takayuki Koga, Combiz Khozoie, Tytus D. Mak, Boo-Hyon Kang, Albert J. Fornace, Jeffrey M. Peters

TOXICOLOGY, 311(3) 87-98, Sep, 2013 Peer-reviewed

Misc.

PPARα-mediated regulation mechanisms of fatty acid 2-hydroxylase (FA2H) expression in MDA-MB-231 cells

平尾雅代, 境絃樹, 古賀貴之, 田中満崇, 杉原成美, 瀧口益史, 竹田修三

日本薬学会年会要旨集(Web), 142nd, 2022
Hepatic Bhmt regulates suppressive effect of methionine on chemical-induced dermatitis.

古賀貴之, 廣村信, 平尾雅代, 竹田修三, 石田卓已, 石井祐次, 小武家優子, 戸田晶久, 副田二三夫

日本薬学会年会要旨集(Web), 142nd, 2022
Cannabidiolic acid mediated-down-regulation of COX-2 expression through the abrogation of PPARβ/δ signaling

平尾雅代, 古賀貴之, 境絃樹, 瀧口益史, 戸田晶久, 杉原成美, 竹田修三

Journal of Toxicological Sciences, 46(Supplement), 2021
Selenium binding protein 1 regulates suppressive effect of methionine on chemical-induced dermatitis.

古賀貴之, 廣村信, SONG Yingxia, 石井祐次, 平尾雅代, 竹田修三, 石田卓已, 小武家優子, 戸田晶久, 副田二三夫

衛生薬学・環境トキシコロジー講演要旨集, 2021, 2021
Selenium binding protein1(Selenbp1)欠損が高脂肪食誘発性脂肪肝へ及ぼす影響の解析

古賀貴之, 立川怜那, 廣村信, 香川正太, 石井祐次, 平尾雅代, 竹田修三, 石田卓已, 長島史裕, 小武家優子 …

日本薬学会九州支部大会講演要旨集, 38th (CD-ROM), 2021
Cannabidiolic acid down-regulates COX-2 expression through abrogating PPARβ/δ function

平尾雅代, 古賀貴之, 境絃樹, 境絃樹, 瀧口益史, 戸田晶久, 杉原成美, 竹田修三, 竹田修三

日本薬学会年会要旨集(Web), 141st, 2021
Study on the mechanism of a reduced gonadotropin in fetus by maternal exposure to TCDD: analysis of the effect on methionine and folic acid metabolisms and relevance in decreased α-lipoic acid.

佐野宏江, LI Ren-Shi, LI Ren-Shi, CHEN Hong-Bin, 古賀貴之, 松尾友樹, 武田知起, 武田知起, 田中嘉孝, 石井祐次

日本薬学会年会要旨集(Web), 141st, 2021
Cannabidiolic acid down-regulation of COX-2 expression through abrogation of PPARβ/δ function

平尾雅代, 竹田修三, 古賀貴之, 瀧口益史, 戸田晶久

日本薬学会年会要旨集(CD-ROM), 140th 27X-am05, Mar, 2020
Selenium binding protein 1 (Selenbp1) modulates chemical-induced dermatitis.

古賀貴之, 廣村信, SONG Yingxia, 武田知起, 石井祐次, 石田卓已, 小武家優子, 副田二三夫, 戸田晶久

衛生薬学・環境トキシコロジー講演要旨集, 2020, 2020
Ablation of selenium binding protein 1 (Selenbp1) alters lipid metabolism and oxidative stress.

SONG Yingxia, 黒瀬厚, LI Ren-shi, 武田知起, 小野村優子, 古賀貴之, 石田卓已, 田中嘉孝, 石井祐次

衛生薬学・環境トキシコロジー講演要旨集, 2020, 2020
ダイオキシンの母体曝露による胎児視床下部におけるS-adenosylmethionine(SAM)の低下と関連酵素の変動

佐野宏江, 李任時, 松尾友樹, 松下武志, 陳宏斌, 古賀貴之, 武田知起, 武田知起, 田中嘉孝, 石井祐次

日本薬学会年会要旨集(CD-ROM), 139th, 2019
アミノ酸によるアレルギー性皮膚炎抑制作用の系統差への肝臓の寄与の検討

古賀貴之, 井上貴恵, 平山芙香, 武田知起, 石井祐次, 廣村信, 副田二三夫, 戸田晶久

日本薬学会年会要旨集(CD-ROM), 139th, 2019
ダイオキシン母体曝露による胎児ゴナドトロピン低下機構:胎児視床下部の葉酸代謝系の亢進とα-リポ酸補給による回復

佐野宏江, LI Ren-Shi, LI Ren-Shi, CHEN Hong-Bin, 古賀貴之, 松下武志, 松尾友樹, 武田知起, 武田知起, 田中嘉孝 …

衛生薬学・環境トキシコロジー講演要旨集, 2019, 2019
セレン結合性タンパク質1(SelenBP1)の脂質代謝における役割:SelenBP1欠損マウスを用いた検討

宋穎霞, 李任時, 武田知起, 小野村優子, 古賀貴之, 石田卓巳, 武知進士, 田中嘉孝, 石井祐次

日本薬学会九州支部大会講演要旨集, 36th, 2019
ダイオキシンの母体曝露による胎児視床下部におけるS-adenosylmethionine(SAM)関連酵素の変動

佐野宏江, LI Ren-Shi, 松尾友樹, 松下武志, CHEN Hong-Bin, 古賀貴之, 武田知起, 武田知起, 田中嘉孝, 石井祐次

衛生薬学・環境トキシコロジー講演要旨集, 2018, 2018
アミノ酸補給療法のアトピー性皮膚炎に対する有効性の評価

古賀貴之, 平山芙香, 井上貴恵, 武田知起, 石井祐次, 副田二三夫, 廣村信, 戸田晶久

日本薬学会年会要旨集(CD-ROM), 138th, 2018
アミノ酸補給療法によるアレルギー性皮膚炎抑制作用の系統差の解析

古賀貴之, 井上貴恵, 平山芙香, 武田知起, 石井祐次, 廣村信, 副田二三夫, 戸田晶久

衛生薬学・環境トキシコロジー講演要旨集, 2018, 2018
ダイオキシン依存的な胎児期の性ステロイド合成系障害に対するα-リポ酸減少の寄与と機構

松尾友樹, 武田知起, 古賀貴之, 服部友紀子, 服部友紀子, 石井祐次, 山田英之

衛生薬学・環境トキシコロジー講演要旨集, 2016, 2016
ダイオキシン依存的な胎児・性ステロイド合成障害に対するα-リポ酸とチアミンの効果ならびにその機構

藤木章央, 古賀貴之, 武田知起, 石井祐次, 山田英之

衛生薬学・環境トキシコロジー講演要旨集, 2013, 2013
Dioxin-induced Disorders in Fetal Steroidogenesis and Gonadotropin Formation: Minor Contribution of Oxidative Stress to the Damages and the Protective Effect of a Vitamin, a-Lipoic Acid

Takayuki Koga, Tomoki Takeda, Takumi Ishida, Yuji Ishii, Hideyuki Yamada

DRUG METABOLISM REVIEWS, 42 123-124, Aug, 2010

Presentations

Analysis of strain difference in suppressive effects of amino acid supplementation to chemical-induced dermatitis

Koga T, Inoue K, Hirayama F, Takeda T, Ishii Y, Hiromura M, Soeda F, Toda A

Sep 10, 2018
アトピー性皮膚炎発症・進行過程におけるアミノ酸補給療法の有効性の評価

古賀貴之, 平山芙香, 井上貴恵, 武田知起, 石井祐次, 副田二三夫, 廣村信, 戸田晶久

日本薬学会第138年会, Mar 26, 2018
Effects of amino acid supplementation on development of chemical-induced dermatitis.

Koga K, Inoue K, Hirayama F, Takeda T, Ishii Y, Soeda F, Hiromura M, Toda A

Sep 1, 2017
アトピー性皮膚炎重症化における皮膚‐肝連関の解析

古賀貴之, 日高龍, 井上貴恵, 武田知起, 石井祐次, 山田英之, 副田二三夫, 廣村信, 戸田晶久

日本薬学会第137年会, Mar 26, 2017
2,3,7,8-Tetrachlorodibenzo-p-dioxin の胎児視床下部‐下垂体‐性腺系への障害とその回復：メタボロームとエネルギー産生系を中心とした解析

古賀貴之, 石田卓巳, 武田知起, 石井祐次, 山田英之

日本薬学会九州支部大会, Dec, 2011
Damage to fetal pituitary-gonad axis by 2,3,7,8-tetrachlorodibenzo-p-dioxin: mechanism involving the disturbance of hypothalamic/pituitary metabolome and energy production.

Koga T, ishida T, Takeda T, Ishii Y, Yamada H

Oct, 2011
TCDD 母体曝露におけるラット胎児・性ステロイドホルモン含量への影響

古賀貴之, 木庭彰彦, 喜多知美, 武田知起, 石井祐次, 山田英之

日本薬学会第131年会, Mar, 2011
Dioxin-induced disorders in fetal steroidogenesis and gonadotropin formation: minor contribution of oxidative stress to the damages and the protective effect of a vitamin, α-lipoic acid.

Koga T, Takeda T, Ishida T, Ishii Y, Yamada H

9th International ISSX Meeting, Sep, 2010
ダイオキシンによるラット胎児脳下垂体−生殖腺機能に対するα-リポ酸の効果

古賀貴之, 武田知起, 石井祐次, 石田卓巳, 山田英之

日本薬学会第130年会, Mar, 2010
Examination for established way of attenuation against dioxin-induced disorder of sex-steroid synthesis

Koga T, Takeda T, Ishii Y, Ishida T, Yamada H

Nov, 2009
Restoration by α-lipoic acid of dioxin-induced attenuation in the fetal expression of stroidogenic proteins and gonadotropins.

Koga T, Takeda T, Ishii Y, Ishida T, Yamada H

HORIBA International Conference: 21th Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease, Oct, 2009
ダイオキシンによるラット胎児・性ホルモン合成障害の軽減：抗酸化物質を用いた検討と機構解析

古賀貴之, 武田知起, 松本悠揮, 石井祐次, 石田卓巳, 山田英之

日本薬学会第129年会, Mar, 2009
ダイオキシンによるラット胎児・性ホルモン合成障害の抗酸化物質による軽減

古賀貴之, 武田知起, 松本悠揮, 石井祐次, 石田卓巳, 山田英之

日本薬学会九州支部大会, Dec, 2008
Dioxin-induced disorder of sex-steroid synthesis and its restoration with α-lipoic acid

Koga T, Takeda T, Matsumoto Y, Ishii Y, Ishida T, Yamada H

Oct, 2008

Teaching Experience

Sep, 2021 - Present

食品衛生学Ⅱ (第一薬科大学薬学部)
Apr, 2021 - Present

食品衛生学Ⅰ (第一薬科大学薬学部)
Apr, 2014 - Present

衛生薬学実習 (第一薬科大学薬学部)
Sep, 2014 - Mar, 2016

環境衛生学Ⅰ (第一薬科大学薬学部)
Apr, 2014 - Aug, 2015

環境衛生学Ⅱ (第一薬科大学薬学部)

Professional Memberships

Research Projects

Creation of a novel dermatitis treatment strategy with Selenbp1

Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022
アトピー性皮膚炎におけるアミノ酸補給療法の有効性の検討

学術研究振興資金（若手研究者奨励金）, 日本私立学校振興・共済事業団, May, 2017 - Mar, 2018

古賀貴之
アレルギー性接触皮膚炎治療法としての恒常的なメチオニン摂取の有用性の評価

若手研究者奨励金, 第一薬科大学, Apr, 2017 - Mar, 2018

古賀貴之
乳酸菌によるアトピー性皮膚炎発症制御機構の解析

若手研究者奨励金, 第一薬科大学, Apr, 2015 - Mar, 2016

古賀貴之

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