2006年10月13日
Herpes simplex virus encephalitis in human UNC-93B deficiency.
Science (New York, N.Y.)
- 巻
- 314
- 号
- 5797
- 開始ページ
- 308
- 終了ページ
- 12
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/science.1128346
- 出版者・発行元
- AMER ASSOC ADVANCEMENT SCIENCE
Herpes simplex virus-1 (HSV-1) encephalitis (HSE) is the most common form of sporadic viral encephalitis in western countries. Its pathogenesis remains unclear, as it affects otherwise healthy patients and only a small minority of HSV-1-infected individuals. Here, we elucidate a genetic etiology for HSE in two children with autosomal recessive deficiency in the intracellular protein UNC-93B, resulting in impaired cellular interferon-alpha/beta and -lambda antiviral responses. HSE can result from a single-gene immunodeficiency that does not compromise immunity to most pathogens, unlike most known primary immunodeficiencies. Other severe infectious diseases may also reflect monogenic disorders of immunity.
- リンク情報
-
- DOI
- https://doi.org/10.1126/science.1128346
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/16973841
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000241194100044&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33750016788&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=33750016788&origin=inward
- URL
- http://europepmc.org/abstract/med/16973841
- URL
- http://orcid.org/0000-0002-7019-1872
- ID情報
-
- DOI : 10.1126/science.1128346
- ISSN : 0036-8075
- eISSN : 1095-9203
- ORCIDのPut Code : 41626672
- PubMed ID : 16973841
- SCOPUS ID : 33750016788
- Web of Science ID : WOS:000241194100044