論文

国際誌
2022年2月23日

Pretreatment plasma cytokine levels as potential predictors of short-term remission of depression

The World Journal of Biological Psychiatry
  • Kiyokazu Atake
  • Hikaru Hori
  • Yuki Kageyama
  • Yosuke Koshikawa
  • Ryohei Igata
  • Hirotaka Tominaga
  • Asuka Katsuki
  • Hiroki B
  • o
  • Shiho Sakai
  • Keiichiro Nishida
  • Yoshiteru Takekita
  • Tadafumi Kato
  • Toshihiko Kinoshita
  • Masaki Kato
  • 全て表示

開始ページ
1
終了ページ
25
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1080/15622975.2022.2045354
出版者・発行元
Informa {UK} Limited

OBJECTIVES: The response to antidepressants varies significantly among individuals and is difficult to predict before treatment. In this randomised control trial, we explored cytokines that correlate with the therapeutic effect of mirtazapine (MIR) and selective serotonin reuptake inhibitors (SSRIs) and whether they could be predictors of remission for each antidepressant. METHODS: Plasma cytokines, such as tumour necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, and granulocyte-macrophage colony-stimulating factor (GM-CSF) were assayed in 95 participants before medication and assayed by the enzyme-linked immunosorbent assay. The Hamilton Rating Scale for Depression assessed depressive symptoms over 4 weeks. RESULTS: In the SSRI group, the baseline GM-CSF level was significantly higher in the remission group than in the non-remission group (p = .022). In the MIR group, the baseline level of TNF-α was significantly higher (p = .039) and IL-2 was lower (p = .032) in the remission group than in the non-remission group. In patients prescribed with MIR, the cut-off values of TNF-α (10.035 pg/mL) and IL-2 (1.170 pg/mL) calculated from the receiver operating characteristic curve suggested that the remission rate, which corresponds to a positive predictive value, could be increased from 31.3% to 60.0% and 50.0%, respectively. For those prescribed with SSRIs, the remission rate was 37.0% and using the cut-off value of GM-CSF (0.205 pg/mL), the remission rate could be almost doubled to 70%. CONCLUSIONS: Our study shows that pre-treatment plasma concentrations of TNF-α, IL-2, and GM-CSF may suggest the predictability of remission by SSRIs or MIR.

リンク情報
DOI
https://doi.org/10.1080/15622975.2022.2045354
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/35193470
ID情報
  • DOI : 10.1080/15622975.2022.2045354
  • ISSN : 1562-2975
  • ISSN : 1814-1412
  • ORCIDのPut Code : 109075326
  • PubMed ID : 35193470

エクスポート
BibTeX RIS