論文

査読有り
2022年1月28日

Mother's iodine exposure and infants' hypothyroidism: the Japan Environment and Children's Study (JECS).

Endocrine journal
  • Hiroshi Yokomichi
  • Mie Mochizuki
  • Reiji Kojima
  • Sayaka Horiuchi
  • Tadao Ooka
  • Yuka Akiyama
  • Kunio Miyake
  • Megumi Kushima
  • Sanae Otawa
  • Ryoji Shinohara
  • Zentaro Yamagata
  • 全て表示

69
1
開始ページ
9
終了ページ
21
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1507/endocrj.EJ21-0168

In this study, we aimed to determine the association of neonatal/post-neonatal hypothyroidism with mother's iodine exposure, especially povidone iodine disinfection, and hysterosalpingography. Participants were mother-child pairs in a Japanese birth cohort (n = 100,286). Risk factors of hypothyroidism were supplement intake, seaweed intake, other daily iodine intake, povidone iodine disinfection at delivery, and maternal history of hysterosalpingography, thyroid disease (Graves' disease and Hashimoto's thyroiditis), and medication (thiamazole and levothyroxine). Congenital hypothyroidism (CH) at age 1 year was assessed using a questionnaire. Transient hypothyroidism was defined as elevated thyroid stimulating hormone level at birth and absence of CH at age 1 year. The incidence of CH at age 1 year per 100 children was 1.1 for those born at 22-30 weeks' gestation, 0.17 following povidone iodine disinfection, and 0.07, 0.95, 0.81, 1.17, and 1.15 with a maternal history of hysterosalpingography, Graves' disease, Hashimoto's thyroiditis, thiamazole use, and levothyroxine use, respectively. Odds ratios (95% confidence intervals) of CH at age 1 year for povidone iodine disinfection, hysterosalpingography history, maternal Graves' disease, and maternal Hashimoto's thyroiditis were 1.13 (0.71-1.79), 0.47 (0.07-3.36), 7.06 (3.70-13.5), and 5.93 (2.90-12.1), respectively. For transient hypothyroidism for povidone iodine disinfection and hysterosalpingography history, these values were 1.99 (1.51-2.62) and 0.63 (0.20-1.96), respectively. Maternal thyroid disease greatly increased neonatal/post-neonatal hypothyroidism risk. Povidone iodine disinfection may increase transient hypothyroidism risk but not the risk at 1 year of age. Hysterosalpingography does not increase hypothyroidism risk from birth to age 1 year.

リンク情報
DOI
https://doi.org/10.1507/endocrj.EJ21-0168
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34433732
ID情報
  • DOI : 10.1507/endocrj.EJ21-0168
  • PubMed ID : 34433732

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