1991年10月
EFFECT OF NALOXONE ON TRANSMISSION IN EXCITATORY AND INHIBITORY SPINAL REFLEX PATHWAYS
NEUROSCIENCE RESEARCH
- ,
- 巻
- 12
- 号
- 2
- 開始ページ
- 388
- 終了ページ
- 391
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/0168-0102(91)90006-K
- 出版者・発行元
- ELSEVIER SCI IRELAND LTD
The effect of systemic administration of naloxone on transmission in hindlimb reflex pathways was investigated in acute low spinal cats by conditioning monosynaptic reflexes. A marked enhancement of excitatory effects from cutaneous, joint, group II and III muscle afferents was observed in posterior biceps and semitendinosus motoneurones in 4 out of 6 experiments. In contrast, inhibitory synaptic effects in gastrocnemius and soleus motoneurones were not enhanced except weakly in one experiment. The effects of naloxone are different from those observed after spinal cord lesions interrupting axons of a previously described group of upper lumbar propriospinal neurones, which tonically suppress reflex transmission in the acute low spinal state. It is postulated that the suppression exerted by this group of neurones is not dependent on endogenous opioid peptides.
- リンク情報
- ID情報
-
- DOI : 10.1016/0168-0102(91)90006-K
- ISSN : 0168-0102
- Web of Science ID : WOS:A1991GP19400006