論文

査読有り
2008年10月

Nigral Inhibition of GABAergic Neurons in Mouse Superior Colliculus

JOURNAL OF NEUROSCIENCE
  • Katsuyuki Kaneda
  • ,
  • Kaoru Isa
  • ,
  • Yuchio Yanagawa
  • ,
  • Tadashi Isa

28
43
開始ページ
11071
終了ページ
11078
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1523/JNEUROSCI.3263-08.2008
出版者・発行元
SOC NEUROSCIENCE

The current dominant concept for the control of saccadic eye movements by the basal ganglia is that release from tonic GABAergic inhibition by the substantia nigra pars reticulata (SNr) triggers burst firings of intermediate gray layer (SGI) neurons in the superior colliculus (SC) to allow saccade initiation. This hypothesis is based on the assumption that SNr cells inhibit excitatory projection neurons in the SGI. Here we show that nigrotectal fibers are connected to local GABAergic neurons in the SGI with a similar frequency to non-GABAergic neurons. This was accomplished by applying neuroanatomical tracing and slice electrophysiological experiments in GAD67-green fluorescent protein (GFP) knock-in mice, in which GABAergic neurons specifically express GFP. We also found that GABA(A), but not GABA(B), receptors subserve nigrotectal transmission. The present results revealed a novel aspect on the role of the basal ganglia in the control of saccades, e. g., the SNr not only regulates burst initiation but also modulates the spatiotemporal properties of premotor neurons via connections to local GABAergic neurons in the SC.

リンク情報
DOI
https://doi.org/10.1523/JNEUROSCI.3263-08.2008
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/18945914
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000260265700030&DestApp=WOS_CPL
ID情報
  • DOI : 10.1523/JNEUROSCI.3263-08.2008
  • ISSN : 0270-6474
  • PubMed ID : 18945914
  • Web of Science ID : WOS:000260265700030

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