tadashi uemura

Last updated: Aug 7, 2018 at 18:00

Name	tadashi uemura

Research Interests

planar cell polarity(6) , dendrite(9) , cadherin superfamily(1) , Drosophila(55) , Nutritient balance(1) , metabolism(165) , omics(21) , Nutri-developmental biology(1)

Published Papers

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Map7/7D1 and Dvl form a feedback loop that facilitates microtubule remodeling and Wnt5a signaling.

Koji Kikuchi, Akira Nakamura, Masaki Arata, Dongbo Shi, Mami Nakagawa, Tsubasa Tanaka, Tadashi Uemura, Toshihiko Fujimori, Akira Kikuchi, Akiyoshi Uezu, Yasuhisa Sakamoto, and Hiroyuki Nakanishi

EMBO reports in press. Jun 2018 [Refereed]

Small conductance Ca2+ -activated K+ channels induce the firing pause periods during the activation of Drosophila nociceptive neurons.

Onodera K, Baba S, Murakami A, Uemura T, Usui T

eLife 6 Oct 2017 [Refereed]

Difference in Dachsous levels between migrating cells coordinates the direction of collective cell migration

Masaki Arata, Kaoru Sugimura, and Tadashi Uemura.

Developmental Cell 42(5) 479-497.e10 Sep 2017 [Refereed]

Mitochondrial dysfunction induces dendritic loss via eIF2α phosphorylation.

Taiichi Tsuyama, Asako Tsubouchi, Tadao Usui, Hiromi Imamura, and Tadashi Uemura.

Journal of Cell Biology 216(3) 815-834 Mar 2017 [Refereed]

Nutrient-dependent increased dendritic arborization of somatosensory neurons.

Watanabe K, Furumizo Y, Usui T, Hattori Y, Uemura T

Genes to cells : devoted to molecular & cellular mechanisms 22(1) 105-114 Jan 2017 [Refereed]

Mechanical regulation of three-dimensional epithelial fold pattern formation in the mouse oviduct.

Hiroshi Koyama, Dongbo Shi, Makoto Suzuki, Naoto Ueno, Tadashi Uemura, Toshihiko Fujimori.

The Biophysical Journal 111(3) 650-665 Aug 2016 [Refereed]

Dynamics of planar cell polarity protein Vangl2 in the mouse oviduct epithelium

Dongbo Shi, Fumiko Usami, Kouji Komatsu, Sanae Oka, Takaya Abe, Tadashi Uemura, Toshihiko Fujimori

Mechanisms of Development 141 78-89 Aug 2016 [Refereed]

Neuronal processing of noxious thermal stimuli mediated by dendritic Ca(2+) influx in Drosophila somatosensory neurons.

Terada S, Matsubara D, Onodera K, Matsuzaki M, Uemura T, Usui T

eLife 5(FEBRUARY2016) Feb 2016 [Refereed]

平面内細胞極性シグナル

石　東博, 藤森　俊彦, 上村　匡

生体の科学　増大号 66(5) 446-447 Oct 2015 [Refereed]

Celsr1 is required for the generation of polarity at multiple levels of the mouse oviduct.

Shi D, Komatsu K, Hirao M, Toyooka Y, Koyama H, Tissir F, Goffinet AM, Uemura T, Fujimori T

Development (Cambridge, England) 141(23) 4558-4568 Dec 2014 [Refereed]

生命動態システム科学 II.数理生物学 6.補細胞・多細胞社会(2)神経細胞の個性を生み出す転写調節ネットワーク

UEMURA TADASHI, HATTORI YUKAKO

生体の科学 65(5) 472-473 Oct 2014 [Refereed]

A novel planar polarity gene pepsinogen-like regulates wingless expression in a posttranscriptional manner.

Mouri K, Nishino Y, Arata M, Shi D, Horiuchi SY, Uemura T

Developmental dynamics : an official publication of the American Association of Anatomists 243(6) 791-799 Jun 2014 [Refereed]

Age-dependent deterioration of locomotion in Drosophila melanogaster deficient in the homologue of amyotrophic lateral sclerosis 2.

Takayama Y, Itoh RE, Tsuyama T, Uemura T

Genes to cells : devoted to molecular & cellular mechanisms 19(6) 464-477 Jun 2014 [Refereed]

An evolutionarily conserved protein CHORD regulates scaling of dendritic arbors with body size.

Shimono K, Fujishima K, Nomura T, Ohashi M, Usui T, Kengaku M, Toyoda A, Uemura T

Scientific reports 4 4415 Mar 2014 [Refereed]

Sensory-neuron subtype-specific transcriptional programs controlling dendrite morphogenesis: genome-wide analysis of Abrupt and Knot/Collier.

Hattori Y, Usui T, Satoh D, Moriyama S, Shimono K, Itoh T, Shirahige K, Uemura T

Developmental cell 27(5) 530-544 Dec 2013 [Refereed]

GBAの機能喪失によりパーキンソン病モデルショウジョウバエの神経変性は増悪する

鈴木マリ, 藤掛伸宏, 和田圭司, 上村匡, 永井義隆

臨床神経学 53(12) 1525-1525 Dec 2013

In vivo fluorescent adenosine 5'-triphosphate (ATP) imaging of Drosophila melanogaster and Caenorhabditis elegans by using a genetically encoded fluorescent ATP biosensor optimized for low temperatures.

Tsuyama T, Kishikawa J, Han YW, Harada Y, Tsubouchi A, Noji H, Kakizuka A, Yokoyama K, Uemura T, Imamura H

Analytical chemistry 85(16) 7889-7896 Aug 2013 [Refereed]

Atypical cadherin negotiates a turn.

Shi D, Fujimori T, Uemura T

Developmental cell 26(1) 1-2 Jul 2013 [Refereed]

High-resolution in vivo imaging of regenerating dendrites of Drosophila sensory neurons during metamorphosis: local filopodial degeneration and heterotypic dendrite-dendrite contacts.

Satoh D, Suyama R, Kimura K, Uemura T

Genes to cells : devoted to molecular & cellular mechanisms 17(12) 939-951 Dec 2012 [Refereed]

Cohesin controls planar cell polarity by regulating the level of the seven-pass transmembrane cadherin Flamingo.

Mouri K, Horiuchi SY, Uemura T

Genes to cells : devoted to molecular & cellular mechanisms 17(6) 509-524 Jun 2012 [Refereed]

Snakeskin, a membrane protein associated with smooth septate junctions, is required for intestinal barrier function in Drosophila.

Yanagihashi Y, Usui T, Izumi Y, Yonemura S, Sumida M, Tsukita S, Uemura T, Furuse M

Journal of cell science 125(Pt 8) 1980-1990 Apr 2012 [Refereed]

Yoshiki Hotta's challenge: from 2004 onwards.

Uemura T, Sugimura K

Journal of neurogenetics 26(1) 22-24 Mar 2012 [Refereed]

The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons

D. Matsubara; S.-Y. Horiuchi; K. Shimono; T. Usui; T. Uemura

Genes and Development 25(18) 1982-1996 Sep 2011 [Refereed]

Analysis of ciliary beat frequency and ovum transport ability in the mouse oviduct

D. Shi; K. Komatsu; T. Uemura; T. Fujimori

Genes to Cells 16(3) 282-290 Mar 2011 [Refereed]

Golden goal collaborates with flamingo in conferring synaptic-layer specificity in the visual system

S. Hakeda-Suzuki; S. Berger-Müller; T. Tomasi; T. Usui; S.-Y. Horiuchi; T. Uemura; T. Suzuki

Nature Neuroscience 14(3) 314-323 Mar 2011 [Refereed]

Differential hippo signaling in early mouse embryos.

T. Uemura

Developmental cell 20(3) e3 Mar 2011 [Refereed]

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Atypical cadherins dachsous and fat control dynamics of noncentrosomal microtubules in planar cell polarity

T. Harumoto; M. Ito; Y. Shimada; T.J. Kobayashi; H.R. Ueda; B. Lu; T. Uemura

Developmental Cell 19(3) 389-401 Sep 2010 [Refereed]

2-haloacrylate hydratase, a new class of flavoenzyme that catalyzes the addition of water to the substrate for dehalogenation

A.M. Mowafy; T. Kurihara; A. Kurata; T. Uemura; N. Esaki

Applied and Environmental Microbiology 76(18) 6032-6037 Sep 2010 [Refereed]

神経細胞樹状突起パターンの再編・維持を制御する分子の探索(Hunting for genes that regulate remodeling and life-long maintenance of dendritic arbors)

下野耕平, 野村尚史, 碓井理夫, 上村匡

神経化学 49(2-3) 710-710 Aug 2010

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus

F. Tissir; Y. Qu; M. Montcouquiol; L. Zhou; K. Komatsu; D. Shi; T. Fujimori; J. Labeau; D. Tyteca; P. Courtoy; Y. Poumay; T. Uemura; A.M. Goffinet

Nature Neuroscience 13(6) 700-707 Jun 2010 [Refereed]

Crossveinless-c, the Drosophila homolog of tumor suppressor DLC1, regulates directional elongation of dendritic branches via down-regulating Rho1 activity

D. Sato; K. Sugimura; D. Satoh; T. Uemura

Genes to Cells 15(5) 485-500 May 2010 [Refereed]

Computational modeling of dendritic tiling by diffusible extracellular suppressor

K. Shimono; K. Sugimura; M. Kengaku; T. Uemura; A. Mochizuki

Genes to Cells 15(2) 137-149 Feb 2010 [Refereed]

Mitochondrial protein Preli-like is required for development of dendritic arbors and prevents their regression in the Drosophila sensory nervous system

A. Tsubouchi; T. Tsuyama; M. Fujioka; H. Kohda; K. Okamoto-Furuta; T. Aigaki; T. Uemura

Development 136(22) 3757-3766 Nov 2009 [Refereed]

Multidendritic sensory neurons in the adult Drosophila abdomen: Origins, dendritic morphology, and segment- and age-dependent programmed cell death

K. Shimono; A. Fujimoto; T. Tsuyama; M. Yamamoto-Kochi; M. Sato; Y. Hattori; K. Sugimura; T. Usui; K.-I. Kimura; T. Uemura

Neural Development 4(1) 37 Oct 2009 [Refereed]

Conserved alternative splicing and expression patterns of arthropod N-cadherin.

Hsu SN, Yonekura S, Ting CY, Robertson HM, Iwai Y, Uemura T, Lee CH, Chiba A

PLoS genetics 5(4) e1000441 Apr 2009 [Refereed]

Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes

D. Satoh; D. Sato; T. Tsuyama; M. Saito; H. Ohkura; M.M. Rolls; F. Ishikawa; T. Uemura

Nature Cell Biology 10(10) 1164-1171 Oct 2008 [Refereed]

Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for mouse development

K. Kousaka; H. Kiyonari; N. Oshima; A. Nagafuchi; Y. Shima; O. Chisaka; T. Uemura

Genesis 46(5) 246-255 May 2008 [Refereed]

【神経の分化、回路形成、機能発現】神経の発生と分化　神経細胞の形態制御　多様な樹状突起パターンの形成とリモデリング

佐藤大祐, 古知美暁[山本], 藤本梓, 服部佑佳子, 上村匡

蛋白質・核酸・酵素 53(4) 393-399 Mar 2008

近年、樹状突起の分岐の複雑度、伸長、維持、あるいは刈込みなどをコントロールする分子群が発見されてきている。しかしながら、さまざまなニューロンがそれぞれ特徴的な樹状突起パターンを、どのように形づくり、そしてリモデリングするかについては、われわれの理解はまだ断片的なレベルにとどまっている。この総説では、ショウジョウバエのdendritic arborization neuron(da neuron)をモデル系とした研究を中心に紹介する。(著者抄録)

[Generation and remodeling of diverse dendritic patterns].

D. Satoh; M. Yamamoto-Kochi; A. Fujimoto; Y. Hattori; T. Uemura

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 53(4 Suppl) 393-399 Mar 2008 [Refereed]

Self-organizing mechanism for development of space-filling neuronal dendrites

K. Sugimura; K. Shimono; T. Uemura; A. Mochizuki

PLoS Computational Biology 3(11) 2143-2154 Nov 2007 [Refereed]

Selective expression of Knot/Collier, a transcriptional regulator of the EBF/Olf-1 family, endows the Drosophila sensory system with neuronal class-specific elaborated dendritic patterns

Y. Hattori; K. Sugimura; T. Uemura

Genes to Cells 12(9) 1011-1022 Sep 2007 [Refereed]

Opposing roles in neurite growth control by two seven-pass transmembrane cadherins

Y. Shima; S.-Y. Kawaguchi; K. Kosaka; M. Nakayama; M. Hoshino; Y. Nabeshima; T. Hirano; T. Uemura

Nature Neuroscience 10(8) 963-969 Aug 2007 [Refereed]

Homophilic Dscam Interactions Control Complex Dendrite Morphogenesis

M.E. Hughes; R. Bortnick; A. Tsubouchi; P. Bäumer; M. Kondo; T. Uemura; D. Schmucker

Neuron 54(3) 417-427 May 2007 [Refereed]

Polarity and intracellular compartmentalization of Drosophila neurons

M.M. Rolls; D. Satoh; P.J. Clyne; A.L. Henner; T. Uemura; C.Q. Doe

Neural Development 2 7 Apr 2007 [Refereed]

Control of Axonal Sprouting and Dendrite Branching by the Nrg-Ank Complex at the Neuron-Glia Interface

M. Yamamoto; R. Ueda; K. Takahashi; K. Saigo; T. Uemura

Current Biology 16(16) 1678-1683 Aug 2006 [Refereed]

Lim kinase regulates the development of olfactory and neuromuscular synapses

L.-H. Ang; W. Chen; Y. Yao; R. Ozawa; E. Tao; J. Yonekura; T. Uemura; H. Keshishian; H. Hing

Developmental Biology 293(1) 178-190 May 2006 [Refereed]

Potential dual molecular interaction of the Drosophila 7-pass transmembrane cadherin Flamingo in dendritic morphogenesis

H. Kimura; T. Usui; A. Tsubouchi; T. Uemura

Journal of Cell Science 119(6) 1118-1129 Mar 2006 [Refereed]

Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium

Y. Shimada; S. Yonemura; H. Ohkura; D. Strutt; T. Uemura

Developmental Cell 10(2) 209-222 Feb 2006 [Refereed]

Cadherins in “Encyclopedic Reference of Neuroscience”. EDT: Binder, Marc D.; Hirokawa, Nobutaka; Windhorst, Uwe; Hirsch, Martin Christian.

Hiroshi Kimura, and Tadashi Uemura.

Springer-Verlag. 2006 [Refereed]

A novel zinc-containing α-keto ester reductase from actinomycete: An approach based on protein chemistry and bioinformatics

K. Ishihara; H. Yamaguchi; T. Omori; T. Uemura; N. Nakajima; N. Esaki

Bioscience, Biotechnology and Biochemistry 68(10) 2120-2127 Oct 2004 [Refereed]

Development of morphological diversity of dendrites in Drosophila by the BTB-zinc finger protein abrupt

K. Sugimura; D. Satoh; P. Estes; S. Crews; T. Uemura

Neuron 43(6) 809-822 Sep 2004 [Refereed]

コフィリン脱リン酸化酵素Slingshotの活性制御機構

太田裕作, 永田恭子[大橋], 千葉秀平, 森玲子, 後藤一路, 西田満, 大橋一正, 高坂和芳, 岩松明彦, 丹羽隆介, 上村匡, 水野健作

生化学 76(9) 1234-1234 Sep 2004

ニューレグリン刺激依存的なコフィリンの脱リン酸化制御機構

千葉秀平, 後藤一路, 大橋恭子[永田], 太田裕作, 西田満, 大橋一正, 高坂和芳, 岩松明彦, 丹羽隆介, 上村匡, 水野健作

生化学 76(9) 1234-1234 Sep 2004

Regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin

Y. Shima; M. Kengaku; T. Hirano; M. Takeichi; T. Uemura

Developmental Cell 7(2) 205-216 Aug 2004 [Refereed]

単一細胞レベルの神経発生　樹状突起のパターン形成の調節(Single Cell Neurogenesis: Extrinsic and intrinsic control of dendritic shaping)

上村匡, 島康之, 杉村薫, 佐藤大祐, 山本美暁, 木村宏史, 碓井理夫, Crews Stephen, 竹市雅俊

神経化学 43(2-3) 340-340 Aug 2004

樹状突起のパターンの多様性を支える分子機構(Development of morphological diversity of dendrites of Drosophila sensory neurons by the BTB-zinc finger protein Abrupt)

杉村薫, 佐藤大祐, Crews Stephen, 上村匡

神経化学 43(2-3) 524-524 Aug 2004

A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia.

Nagata-Ohashi K, Ohta Y, Goto K, Chiba S, Mori R, Nishita M, Ohashi K, Kousaka K, Iwamatsu A, Niwa R, Uemura T, Mizuno K

The Journal of cell biology 165(4) 465-471 May 2004 [Refereed]

Phosphoinositide 3-Kinase-mediated Activation of Cofilin Phosphatase Slingshot and Its Role for Insulin-induced Membrane Protrusion

M. Nishita; Y. Wang; C. Tomizawa; A. Suzuki; R. Niwa; T. Uemura; K. Mizuno

Journal of Biological Chemistry 279(8) 7193-7198 Feb 2004 [Refereed]

【神経回路の機能発現のメカニズム】　神経回路形成の分子的基盤　樹状突起のパターンの多様性を支える機構の解明に向けて

杉村薫, 木村宏史, 上村匡

蛋白質・核酸・酵素 49(3) 310-316 Feb 2004

ニューロンは樹状突起と軸索の2種類の突起を伸長させる.近年,多くの樹状突起のパターン形成制御因子が同定されてきたが,どのようにして様々なニューロンが各々に特徴的な樹状突起を形作るかについては,殆ど明らかにされていない.そこで,ショウジョウバエのdendritic arborization neuronをモデル系に用いて,樹状突起のパターンの多様性を生み出す機構の解明に取り組んでいる一連の研究について紹介した

Breaking Cellular Symmetry along Planar Axes in Drosophila and Vertebrates

T. Uemura; Y. Shimada

Journal of Biochemistry 134(5) 625-630 Nov 2003 [Refereed]

Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin.

Ohta Y, Kousaka K, Nagata-Ohashi K, Ohashi K, Muramoto A, Shima Y, Niwa R, Uemura T, Mizuno K

Genes to cells : devoted to molecular & cellular mechanisms 8(10) 811-824 Oct 2003 [Refereed]

Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells.

Kaji N, Ohashi K, Shuin M, Niwa R, Uemura T, Mizuno K

The Journal of biological chemistry 278(35) 33450-33455 Aug 2003 [Refereed]

Shortstop recruits EB1/APC1 and promotes microtubule assembly at the muscle-tendon junction

A. Subramanian; A. Prokop; M. Yamamoto; K. Sugimura; T. Uemura; J. Betschinger; J.A. Knoblich; T. Volk

Current Biology 13(13) 1086-1095 Jul 2003 [Refereed]

Flamingo regulates R8 axon-axon and axon-target interactions in the Drosophila visual system

K.-A. Senti; T. Usui; K. Boucke; U. Greber; T. Uemura; B.J. Dickson

Current Biology 13(10) 828-832 May 2003 [Refereed]

Distinct developmental modes and lesion-induced reactions of dendrites of two classes of Drosophila sensory neurons

K. Sugimura; M. Yamamoto; R. Niwa; D. Satoh; S. Goto; M. Taniguchi; S. Hayashi; T. Uemura

Journal of Neuroscience 23(9) 3752-3760 May 2003 [Refereed]

Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin.

Endo M, Ohashi K, Sasaki Y, Goshima Y, Niwa R, Uemura T, Mizuno K

The Journal of neuroscience : the official journal of the Society for Neuroscience 23(7) 2527-2537 Apr 2003 [Refereed]

細胞の非対称性を生み出し、増幅・維持するメカニズム

上村　匡

実験医学 21(4) 444-446 Mar 2003 [Refereed]

平面内細胞極性形成の不思議

島田裕子、碓井理夫、上村匡

21(4) 452-459 Mar 2003 [Refereed]

A mosaic genetic screen for genes necessary for Drosophila mushroom body neuronal morphogenesis

J.E. Reuter; T.M. Nardine; A. Penton; P. Billuart; E.K. Scott; T. Usui; T. Uemura; L. Luo

Development 130(6) 1203-1213 Mar 2003 [Refereed]

【細胞の接着と極性形成】　細胞の非対称性を生み出し,増幅・維持するメカニズム

上村匡

実験医学 21(4) 444-446 Mar 2003

アクチン脱重合因子 ADF/コフィリンを脱リン酸化するフォスファターゼ Slingshot

丹羽隆介、上村匡

実験医学 20(16) 2354-2356 Nov 2002 [Refereed]

GETDB, a database compiling expression patterns and molecular locations of a collection of Gal4 enhancer traps

S. Hayashi; K. Ito; Y. Sado; M. Taniguchi; A. Akimoto; H. Takeuchi; T. Aigaki; F. Matsuzaki; H. Nakagoshi; T. Tanimura; R. Ueda; T. Uemura; M. Yoshihara; S. Goto

Genesis 34(1-2) 58-61 Sep 2002 [Refereed]

プロテインホスファターゼ研究の新展開　新規コフィリンホスファターゼSlingshotによるアクチン細胞骨格の制御

大橋恭子[永田], 丹羽隆介, 大橋一正, 上村匡, 水野健作

生化学 74(8) 710-710 Aug 2002

DN-cadherin is required for spatial arrangement of nerve terminals and ultrastructural organization of synapses

Y. Iwai; Y. Hirota; K. Ozaki; H. Okano; M. Takeichi; T. Uemura

Molecular and Cellular Neuroscience 19(3) 375-388 Mar 2002 [Refereed]

Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development

Y. Shima; N.G. Copeland; D.J. Gilbert; N.A. Jenkins; O. Chisaka; M. Takeichi; T. Uemura

Developmental Dynamics 223(3) 321-332 Mar 2002 [Refereed]

Control of actin reorganization by slingshot, a family of phosphatases that dephosphorylate ADF/cofilin

R. Niwa; K. Nagata-Ohashi; M. Takeichi; K. Mizuno; T. Uemura

Cell 108(2) 233-246 Jan 2002 [Refereed]

Asymmetric colocalization of Flamingo, a seven-pass transmembrane cadherin, and Dishevelled in planar cell polarization

Y. Shimada; T. Usui; S.-I. Yanagawa; M. Takeichi; T. Uemura

Current Biology 11(11) 859-863 Jun 2001 [Refereed]

Developmental roles and molecular characterization of a Drosophila homologue of Arabidopsis Argonaute1, the founder of a novel gene superfamily

Y. Kataoka; M. Takeichi; T. Uemura

Genes to Cells 6(4) 313-325 Apr 2001 [Refereed]

Ｗｎｔシグナルと形態形成　　平面内細胞極性形成の分子機構

19(11) 1627-1633 Nov 2000 [Refereed]

【Wntシグナルと形態形成】　平面内細胞極性形成の分子機構

碓井理夫, 上村匡

細胞工学 19(11) 1627-1633 Oct 2000

多くの器官形成において,上皮細胞は頂部-基部極性だけでなく,平面内細胞極性(PCP)と呼ばれる極性を発達させる.平面内極性の形成はPCP経路と呼ばれるシグナルカスケードが制御しており,7回膜貫通型レセプターFrizzledが重要な役割を担っている.著者等はPCP経路に属する新しい因子として,7回膜貫通型カドヘリンFlamingoを発見した.Flamingoの細胞内分布は著しい偏りを示し,しかもこの偏在様式が正常な極性化に必須であるらしい

多細胞系構築の基盤となる細胞の接着と極性化のダイナミクス　神経系と上皮のsingle-cell patterning　7回膜貫通型カドヘリンによる調節

上村匡, 島田裕子, 島康之, 竹市雅俊, 碓井理夫

生化学 72(8) 680-680 Aug 2000

Patterning of cell assemblies regulated by adhesion receptors of the cadherin superfamily

M. Takeichi; S. Nakagawa; S. Aono; T. Usui; T. Uemura

Philosophical Transactions of the Royal Society B: Biological Sciences 355(1399) 885-890 Jul 2000 [Refereed]

Flamingo controls the planar polarity of sensory bristles and asymmetric division of sensory organ precursors in Drosophila.

Lu B, Usui T, Uemura T, Jan L, Jan YN

Current biology : CB 9(21) 1247-1250 Nov 1999 [Refereed]

Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled

T. Usui; Y. Shima; Y. Shimada; S. Hirano; R.W. Burgess; T.L. Schwarz; M. Takeichi; T. Uemura

Cell 98(5) 585-595 Sep 1999 [Refereed]

【ニューロンネットワークを生み出す分子機構の解明】　軸索ガイダンスとマップ形成　(1)カドヘリンスーパーファミリー　細胞間接着を介するメカニズム

岩井陽一, 上村匡

細胞工学 18(1) 27-32 Jan 1999

ニューロンネットワークを生み出す分子機構の解明 I. 軸索ガイダンスとマップ形成 (1) カドヘリンスーパーファミリー細胞間接着を介するメカニズム

岩井陽一;上村匡

細胞工学 18(1) 27-32 Jan 1999 [Refereed]

α-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells

M. Watabe-Uchida; N. Uchida; Y. Imamura; A. Nagafuchi; K. Fujimoto; T. Uemura; S. Vermeulen; F. Van Roy; E.D. Adamson; M. Takeichi

Journal of Cell Biology 142(3) 847-857 Aug 1998 [Refereed]

The cadherin superfamily at the synapse: more members, more missions.

Uemura T

Cell 93(7) 1095-1098 Jun 1998 [Refereed]

Accumulation of Armadillo induced by wingless, dishevelled, and dominant-negative Zeste-white 3 leads to elevated DE-cadherin in Drosophila clone 8 wing disc cells

S.-I. Yanagawa; J.-S. Lee; T. Haruna; H. Oda; T. Uemura; M. Takeichi; A. Ishimoto

Journal of Biological Chemistry 272(40) 25243-25251 Oct 1997 [Refereed]

Axon patterning requires DN-cadherin, a novel neuronal adhesion receptor, in the drosophila embryonic CNS

Y. Iwai; T. Usui; S. Hirano; R. Steward; M. Takeichi; T. Uemura

Neuron 19(1) 77-89 Jul 1997 [Refereed]

Phenotypic analysis of null mutants for DE-cadherin and Armadillo in Drosophila ovaries reveals distinct aspects of their functions in cell adhesion and cytoskeletal organization

H. Oda; T. Uemura; M. Takeichi

Genes to Cells 2(1) 29-40 Jan 1997 [Refereed]

Cadherins in axonal patterning and synaptic connections

M. Takeichi; T. Uemura; Y. Iwai; T. Inoue; S.C. Suzuki; T. Tanaka; N. Uchida

FASEB Journal 11(9) A1285 1997 [Refereed]

Cadherins in brain patterning and neural network formation

M. Takeichi; T. Uemura; Y. Iwai; N. Uchida; T. Inoue; T. Tanaka; S.C. Suzuki

Cold Spring Harbor Symposia on Quantitative Biology 62 505-510 1997 [Refereed]

Cadherin-mediated cell adhesion and cell motility in Drosophila trachea regulated by the transcription factor Escargot.

Tanaka-Matakatsu M, Uemura T, Oda H, Takeichi M, Hayashi S

Development (Cambridge, England) 122(12) 3697-3705 Dec 1996 [Refereed]

ダイナミックな器官形成におけるカドヘリンの機能

上村匡

生化学 68(7) 572-572 Jul 1996

Zygotic Drosophilia E-cadherin expression is required for processes of dynamic epithelial cell rearrangement in the Drosophila embryo

T. Uemura; H. Oda; R. Kraut; S. Hayashi; Y. Kataoka; M. Takeichi

Genes and Development 10(6) 659-671 Mar 1996 [Refereed]

A Drosophila homolog of cadherin associated with Armadillo and essential for embryonic cell-cell adhesion

H. Oda; T. Uemura; Y. Harada; Y. Iwai; M. Takeichi

Developmental Biology 165(2) 716-726 Oct 1994 [Refereed]

Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2.

Mayer-Jaekel RE, Ohkura H, Ferrigno P, Andjelkovic N, Shiomi K, Uemura T, Glover DM, Hemmings BA

Journal of cell science 107 ( Pt 9) 2609-2616 Sep 1994 [Refereed]

Alternative cell fate choice induced by low-level expression of a regulator of protein phosphatase 2A in the Drosophila peripheral nervous system

K. Shiomi; M. Takeichi; Y. Nishida; Y. Nishi; T. Uemura

Development 120(6) 1591-1599 Jun 1994 [Refereed]

Dynamic control of cell-cell adhesion for multicellular organization

M. Takeichi; M. Watabe; S. Shibamoto; F. Ito; H. Oda; T. Uemura; K. Shimamura

Comptes Rendus de l Académie des Sciences - Series III 316(9) 818-821 Sep 1993 [Refereed]

Misc

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スムースセプテイトジャンクションに局在する新規膜タンパク質の同定(Identification of a novel integral membrane protein localizing at smooth septate junctions)

柳橋祐一, 碓井理夫, 米村重信, 月田承一郎, 上村匡, 古瀬幹夫

日本細胞生物学会大会講演要旨集 61回 202-202 May 2009

微小管がつかさどる細胞ダイナミクス平面上において全組織非対称性をどのようにして細胞極性へと関連させるのか(How to connect global tissue asymmetry to cell polarity on the plane)

上村匡, 春本敏之, 島田裕子, 上田泰己, 小林徹也

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 81回・31回 1S23-5 Nov 2008

細胞内ロジスティクス:病態の理解に向けた細胞内物流システム研究樹状突起におけるRab5エンドソームの機能と輸送(Function and transport of Rab5 early endosomes in the dendritic arbors of neurons)

佐藤大祐, 上村匡

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 81回・31回 3S3-5 Nov 2008

カドヘリンスーパーファミリーの多様性 7回膜貫通型カドヘリンは姉妹樹状突起間の相互反発を制御する(Versatile functions of the cadherin superfamily Control of Dendritic Self-Avoidance by Seven-Pass Transmembrane Cadherin in Drosophila Sensory Neurons)

碓井理夫, 堀内伸也, 松原大祐, 下野耕平, 木村宏史, 上村匡

日本細胞生物学会大会講演要旨集 60回 86-86 Jun 2008

ダイニンはRab5エンドソームを輸送して樹状突起の分岐位置を調節する

佐藤大祐, 佐藤太一, 津山泰一, Rolls Melissa M., Doe Chris Q., 大倉洋之, 斉藤基輝, 石川冬木, 上村匡

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 80回・30回 2T9-13 Nov 2007

生命現象にみられるゆらぎ・振動・波樹状突起が空間を埋めるための自己組織化機構(Self-organizing Mechanism for Development of Space-filling Dendrites)

杉村薫, 上村匡, 望月敦史

日本発生生物学会・日本細胞生物学会合同大会要旨集 40回・59回 25-25 May 2007

EBF/Olf-1ファミリーの転写制御因子Knot/Collierの選択的発現によるクラス特異的樹状形態形成(Selective Expression of Knot/Collier, a Transcriptional Regulator of the EBF/Olf-1 Family, Endowed a Class-specific Dendritic Morphogenesis)

服部佑佳子, 杉村薫, 上村匡

日本発生生物学会・日本細胞生物学会合同大会要旨集 40回・59回 158-158 May 2007

ショウジョウバエの知覚ニューロンにおける7回膜貫通型カドヘリンによる樹状細胞回避の制御(Control of Dendritic Avoidance by 7-pass Transmembrane Cadherin in Drosophila Sensory Neurons)

碓井理夫, 堀内伸也, 岩崎慎治, 中村友紀, 木村宏史, 上村匡

日本発生生物学会・日本細胞生物学会合同大会要旨集 40回・59回 170-170 May 2007

FRAP法によるラメリポディア内アクチン線維の動態の解析

渡邉琢也, 大橋一正, 丹羽隆介, 上村匡, 水野健作

日本細胞生物学会大会講演要旨集 56回 XXXVI-XXXVI May 2003

Invivo或いはorganotypic cultureにおける神経細胞の追跡　感覚細胞のクラス特異的な樹状突起のパターン形成

上村匡

日本細胞生物学会大会講演要旨集 56回 1-1 May 2003

細胞骨格と細胞運動　LIMキナーゼとSSHによるラメリポディア内のアクチン線維ターンオーバーの制御

渡邉琢也, 大橋一正, 丹羽隆介, 上村匡, 水野健作

日本細胞生物学会大会講演要旨集 56回 16-16 May 2003

マウスSlingshotファミリーの発現分布と機能解析

太田裕作, 高坂和芳, 大橋一正, 大橋恭子[永田], 島康之, 丹羽隆介, 上村匡, 水野健作

日本細胞生物学会大会講演要旨集 56回 26-26 May 2003

細胞質分裂におけるコフィリンのリン酸化と活性制御

梶紀子, 執印美加, 大橋一正, 丹羽隆介, 上村匡, 水野健作

日本細胞生物学会大会講演要旨集 56回 26-26 May 2003

細胞骨格のダイナミズムに支配される形態形成　ADF/Cofilinを脱リン酸化する新規ホスファターゼファミリーSlingshotによるアクチン再構築の制御(Control of Actin Reorganization by Slingshot, a Novel Family of Phosphatases that Dephosphorylate ADF/Cofilin)

丹羽隆介, 永田恭子[大橋], 竹市雅俊, 水野健作, 上村匡

日本発生生物学会大会講演要旨集 35回 61-62 May 2002

神経突起のパターン形成における7回膜貫通型カドヘリンFlamingoの役割

木村宏史, 碓井理夫, 上村匡

日本発生生物学会大会講演要旨集 35回 258-258 May 2002

神経細胞の移動とかたち作りのメカニズム　7回膜貫通型カドヘリンによる,上皮細胞と神経細胞のパターン形成

上村匡

日本細胞生物学会大会講演要旨集 54回 7-7 May 2001

Books etc

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The Cadherin Superfamily: Key Regulators of Animal Development and Physiology(S. Suzuki and S. Hirano eds.)

Dongbo Shi, Masaki Arata, Tadao Usui, Toshihiko Fujimori, and Tadashi Uemura (Part:Contributor, Chapter 10 (p251-275)Seven-pass transmembrane cadherin CELSRs, and Fat4 and Dchs1 cadherins: from planar cell polarity to three-dimensional organ architecture.)

Springer Jun 2016 ISBN:978-4-431-56031-9

This book presents an overview of the entire field of cadherin research and provides the current basic concept of cadherins. Cadherins have been widely accepted as key regulators of animal development and physiological functions, and it also has b...

Conference Activities & Talks

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Systemic TGFβ/Activin signaling governs adaptive metabolic responses to nutrient balances of Drosophila species.

tadashi uemura

第2回京都生体質量分析研究会シンポジウム 3 Feb 2018 Kyoto Biomolecular Mass Spectrometry Society

個体の成長と成熟を司る栄養応答システムの解明新学術創成研究機構。 [Invited]

tadashi uemura

革新的統合バイオ研究コア栄養・代謝研究ワークショップ「生体トランジスタシスを司る栄養応答システムの動作基盤」 26 Jan 2018 金沢大学新学術創成研究機構革新的統合バイオ研究コア栄養・代謝研究ユニット

Systemic signaling for adaptation to nutrient balances in animal growth.

tadashi uemura

9 Dec 2017 The Molecular Biology Society of Japan

The molecular basis of distinct adaptive responses to nutrient balances between generalist and specialist species.

tadashi uemura

The 3rd International Insect Hormone Workshop. 9 Jul 2017 International Insect Hormone Workshop/丹羽隆介（筑波大学生命環境系・准教授）

The molecular basis of distinct adaptive responses to nutrient balances between generalist and specialist species

tadashi uemura

EMBO|EMBL Symposium "Metabolism in Time and Space: Emerging Links to Cellular and Developmental Programs" 11 May 2017 European Molecular Biology Laboratory

Nutri-developmental biology：栄養バランス変化に適応して成長するシステムの追究 [Invited]

tadashi uemura

第7回HiHA Workshop 23 Sep 2016 HiHA 広島大学健康長寿研究拠点

栄養バランス依存的な個体成長システム—種間比較マルチオミックス解析—

6 Sep 2016 東京農業大学

Tadashi Uemura. Deciphering the molecular basis of responses to nutrient balances governing animal growth [Invited]

tadashi uemura

Duke Nus Medical School NBD Invited Speaker Seminar, 15 Jul 2016

The molecular basis of distinct dietary responses to nutrient balances for animal growth between Drosophila generalist and specialist species.

tadashi uemura

CDB symposium"Size in Development: Growth, Shape and Allometry" 28 Mar 2016 理化学研究所多細胞システム形成研究センター（CDB）

栄養バランスの変化に適応して発生する生体システムとは. [Invited]

tadashi uemura

東京大学分子細胞生物学研究所セミナー 25 Jan 2016 東京大学分子細胞生物学研究所

Interorgan communication controlling size of neuronal dendritic arbors in response to nutritional restriction

Tadashi uemura

The CDB Symposium 2015 "Time in Development" 23 Mar 2015 理化学研究所　多細胞システム形成研究センター（RIKEN CDB）

Making a sensory system: a transcriptional program, scaling growth,and polymodality [Invited]

Tadashi uemura

NTU College of Medicine Seminar 23 Dec 2014 Department and Graduate Institute of Microbiology, College of Medicine, National Taiwan University

Making a sensory system: a transcriptional program, scaling growth, and polymodality [Invited]

Tadashi uemura

ICOB Seminar 22 Dec 2014 Institute of Cellular and Organismic Biology,Academia Sinica

遺伝学的摂動を用いた樹状突起ジオメトリーの演算原理の追究

Tadashi uemura

包括脳ネットワーク　2014年冬のシンポジウム 13 Dec 2014 包括脳ネットワーク

遺伝学的摂動を用いた樹状突起ジオメトリーの演算原理の追究

tadashi uemura

包括脳ネットワーク　2014年冬のシンポジウム 11 Dec 2014

神経細胞樹状突起のスケーリング成長

Tadashi uemura

第37回日本分子生物学会年会 26 Nov 2014 日本分子生物学会

New horizons of planar polarity [Invited]

Tadashi uemura

The　Company of Biologists Workshop "Coordinating postmitotic cells in tissue remodeling" 21 May 2014 The Company of Biologists

Coordinating postmitotic cells in tissue remodeling - Scaling of neuronal dendritic arbors and collective epithelial cell migration - [Invited]

Tadashi uemura

Genes to Cells Seminar 16 May 2014 Cancer Research UK London Research Institute

CHORD regulates scaling of dendritic arbors with body size. [Invited]

Tadashi Uemura

Behavioral Neurogenetics of larval Drosophila: Molecules, Circuits, Computation & Robotics 11 Mar 2014 Behavioral Neurogenetics of larval Drosophila

Linking body size to morphology of neuronal dendritic arbors in adults. [Invited]

Tadashi uemura

ASCB　Annual Meeting 15 Dec 2013 The American Society for Cell Biology

Scaling Dendritic Arbors of Adult Neurons

Tadashi uemura

2nd Asia-Pacific Drosophila Research Conference(APDRC2) 13 May 2013 Asia-Pacific Drosophila Research Conference

Dendritic arborization: input processing, life-long maintenance, and allometry [Invited]

Tadashi uemura

Linda Buck 博士招聘高等研国際シンポジウム「感覚受容と神経回路」 International Symposium on “Sensory Systems and Neural Circuits” 11 Feb 2013 財団法人国際高等研究所

遺伝子ネットワークから細胞ジオメトリーを解く [Invited]

Tadashi Uemura

数学・数理科学と諸科学・産業との連携研究ワークショップ 2 Nov 2012

Linking global tissue asymmetry to cell polarity in 2D or 3D tissue architecture [Invited]

Tadashi Uemura

The Young Scientists' Colloquia 13 Apr 2012 京都大学　物質‐細胞統合システム拠点

The Seven-pass transmembrane cadherin: multiple missions in vivo in “Frontiers in Science – a symposium supported by HFSP” [Invited]

Tadashi Uemura

第34回日本分子生物学会大会 14 Dec 2011

Linking global tissue asymmetry to cell polarity. [Invited]

Tadashi Uemura

Developmental Control of Sex, Growth and Cellular Fate 11 Oct 2011 Cold Spring Harbor Asia

Linking global tissue asymmetry to cell polarity [Invited]

Tadashi Uemura

Exciting Biology Series: “Cellular development: Biology at the interface” 29 Sep 2011 理化学研究所　発生・再生科学総合研究センター（CDB）及びCell Press

Linking global tissue asymmetry to cell polarity on the plane in “Cytoskeleton: Basic, Progress, and Future” [Invited]

Tadashi Uemura

第63回日本細胞生物学会年会 27 Jun 2011

平面内細胞極性における非典型的カドヘリンの機能解析 [Invited]

Tadashi Uemura

神戸大学大学院医学研究科セミナー 15 Apr 2011

Linking global tissue asymmetry to cell polarity on the plane

SDB-JSDB Joint Meeting 5 Aug 2010 Society for Developmental Biology, SDB, 及び日本発生生物学会（JSDB）

Roles of organelle dynamics in shaping neuronal cells in vivo

神経細胞の極性輸送とネットワーク構築 27 Apr 2010 基礎生物学研究所

Quantitative analysis of Fz-vesicle dynamics

PCP MEETING 26 May 2010

動物体内での小胞輸送の定量的解析—平面内細胞極性を舞台として—

Tadashi Uemura

新学術領域研究「細胞内ロジスティクス」班会議 9 Nov 2009

Linking Global Tissue Asymmetry to Cell Polarity on the Plane.

The American Society for Cell Biology/Japan Society for Cell Biology/RIKEN Center for Developmental Biology 2009 Meeting 21 Sep 2009 Building the Body Plan: How Cell Adhesion, Signaling and Cytoskeletal Regulation Shape Morphogenesis

Roles of organelle dynamics in shaping cells in vivo

The 5nd National Taiwan University (NTU)-Kyoto University Mini-Symposium on Molecular and Cell Biology 23 May 2009 The 5nd National Taiwan University (NTU)-Kyoto University

Roles of organelle dynamics in shaping cell

The 50 Annual Drosophila Research Conference 4 Mar 2009 Genetics Society of America

The Cell Workshop, "The Biology of Shape"

GCOE生命数理セミナー 10 Feb 2009 GCOE

分子集合体—オルガネラ—１細胞—器官：マルチスケールでの経時観察と画像解析の実践に向けて

定量生物学の会第１回年会 10 Jan 2009 定量生物学の会

Association Memberships

The Society for Neuroscience(47) , American Society of Cell Biology(19) , JAPAN SOCIETY FOR CELL BIOLOGY(330) , THE JAPAN NEUROSCIENCE SOCIETY(1097) , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN(2391) , JAPANESE SOCIETY OF DEVELOPMENTAL BIOLOGISTS(205) , Japanese Drosophila Reseach Conference(8)