Dopamine supersensitivity psychosis (DSP) is a type of acute exacerbation of recurrent psychosis caused by long term treatment with antipsychotics in schizophrenic patients. Although DSP is exceedingly troublesome for clinicians, effective treatment has not yet been established, Based on clinical research and our animal study, we hypothesize that aripiprazole, an atypical anti psychotic, may reduce the exacerbation of recurrent psychotic episodes. We report the case of a 46 year old female who suffered from schizophrenia with DSP. In this case, sustained treatment with a high dose of aripiprazole gradually reduced the severity of her recurrent psychotic episodes. In conclusion, sustained treatment with aripiprazole may reduce the exacerbation of recurrent psychotic episodes in schizophrenic Patients with DSP, and may be an effective treatment of DSP.