論文

査読有り 筆頭著者 責任著者
2016年1月

Molecular mechanism for cyclic generation of somites: Lessons from mice and zebrafish

DEVELOPMENT GROWTH & DIFFERENTIATION
  • Taijiro Yabe
  • ,
  • Shinji Takada

58
1
開始ページ
31
終了ページ
42
記述言語
英語
掲載種別
DOI
10.1111/dgd.12249
出版者・発行元
WILEY

The somite is the most prominent metameric structure observed during vertebrate embryogenesis, and its metamerism preserves the characteristic structures of the vertebrae and muscles in the adult body. During vertebrate somitogenesis, sequential formation of epithelialized cell boundaries generates the somites. According to the clock and wavefront model, the periodical and sequential generation of somites is achieved by the integration of spatiotemporal information provided by the segmentation clock and wavefront. In the anterior region of the presomitic mesoderm, which is the somite precursor, the orchestration between the segmentation clock and the wavefront achieves morphogenesis of somites through multiple processes such as determination of somite boundary position, generation of morophological boundary, and establishment of the rostrocaudal polarity within a somite. Recently, numerous studies using various model animals including mouse, zebrafish, and chick have gradually revealed the molecular aspect of the clock and wavefront model and the molecular mechanism connecting the segmentation clock and the wavefront to the multiple processes of somite morphogenesis. In this review, we first summarize the current knowledge about the molecular mechanisms underlying the clock and the wavefront and then describe those of the three processes of somite morphogenesis. Especially, we will discuss the conservation and diversification in the molecular network of the somitigenesis among vertebrates, focusing on two typical model animals used for genetic analyses, i.e., the mouse and zebrafish. In this review, we described molecular mechanism for the generation of somites based on the spatiotemporal information provided by segmentation clock and wavefront focusing on the evidences obtained from mouse and zebrafish.

リンク情報
DOI
https://doi.org/10.1111/dgd.12249
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000369344300004&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-84955601247&partnerID=MN8TOARS
URL
http://orcid.org/0000-0002-0843-7472
ID情報
  • DOI : 10.1111/dgd.12249
  • ISSN : 0012-1592
  • eISSN : 1440-169X
  • ORCIDのPut Code : 57916238
  • SCOPUS ID : 84955601247
  • Web of Science ID : WOS:000369344300004

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