論文

国際誌
2018年6月

Effects of Cytochrome P450 (CYP) 2C19 Genotypes on Steady-State Plasma Concentrations of Escitalopram and its Desmethyl Metabolite in Japanese Patients With Depression.

Therapeutic drug monitoring
  • Shoko Tsuchimine
  • ,
  • Shinichiro Ochi
  • ,
  • Misuzu Tajiri
  • ,
  • Yutaro Suzuki
  • ,
  • Norio Sugawara
  • ,
  • Yoshimasa Inoue
  • ,
  • Norio Yasui-Furukori

40
3
開始ページ
356
終了ページ
361
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1097/FTD.0000000000000506

BACKGROUND: Plasma concentrations of the S-enantiomer of citalopram were different between extensive and poor CYP2C19 metabolizers in healthy subjects and depressed patients. However, most studies applied dose-corrected concentrations. Thus, we studied the effects of polymorphisms of the CYP2C19 gene on raw plasma drug concentrations in Japanese patients with depression. METHODS: Subjects in this study consisted of 412 depressed patients receiving 5, 10, 15, or 20 mg of escitalopram once a day. Plasma concentrations of escitalopram and desmethylescitalopram were quantified using HPLC. CYP2C19 genotypes were identified using polymerase chain reaction methods. RESULTS: There were no differences in the steady-state plasma concentrations of escitalopram or desmethylescitalopram in each dose group (5, 10, 15, or 20 mg of escitalopram) among CYP2C19 genotype groups. However, 1-way analysis of variance showed significant effects of CYP2C19 genotypes on the dose-adjusted plasma concentration of escitalopram but not in the dose-adjusted plasma concentration of desmethylescitalopram. Analysis of covariance including age, sex, and body weight showed significant effects of CYP2C19 genotypes on the dose-adjusted plasma concentration of escitalopram and the ratio of desmethylescitalopram to escitalopram. CONCLUSIONS: These findings suggest that the CYP2C19 variants are associated with steady-state plasma concentrations of escitalopram to some extent but are not associated with desmethylescitalopram.

リンク情報
DOI
https://doi.org/10.1097/FTD.0000000000000506
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29570504
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959260
ID情報
  • DOI : 10.1097/FTD.0000000000000506
  • PubMed ID : 29570504
  • PubMed Central 記事ID : PMC5959260

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