論文

査読有り
2013年

The preventive effect of Bacillus subtilus strain DB9011 against experimental infection with enterotoxcemic Escherichia coli in weaning piglets

ANIMAL SCIENCE JOURNAL
  • Takamitsu Tsukahara
  • ,
  • Takeshi Tsuruta
  • ,
  • Nobuo Nakanishi
  • ,
  • Chie Hikita
  • ,
  • Masami Mochizuki
  • ,
  • Keizo Nakayama

84
4
開始ページ
316
終了ページ
321
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/asj.12003
出版者・発行元
WILEY-BLACKWELL

Porcine edema disease (ED) is caused by Shiga toxin 2e-producing Escherichia coli (STEC). Post-weaned piglets often suffer from ED as a result of intestinal infection with STEC, which causes impaired growth performance and high mortality. Antimicrobial therapy is a curative treatment for piglets infected with STEC, but the emergence of antimicrobial-resistant STEC has become a serious problem for Japanese pig farmers. Therefore, an alternative strategy other than antimicrobial therapy is needed for the prevention or treatment of ED. In this study, we evaluated the effect of oral administration of Bacillus subtilisDB9011 (DB9011) to prevent the experimental infection of STEC in weaning piglets. Eight 21-day-old piglets were divided into two groups: STEC challenge with the basal diet, and STEC challenge with DB9011 supplemented diet. The challenge was carried out when the animals were 25, 26 and 27 days old using STEC contained in capsules resistant against gastric digestion. All pigs were euthanized at 36 days of age. DB9011 improved the symptoms of ED and decreased the number of STEC in the ileal digesta and feces. Accordingly, oral administration of DB9011 in weaned piglets prevents ED through the suppression of the growth of STEC in the ileum.

リンク情報
DOI
https://doi.org/10.1111/asj.12003
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000317938900006&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/asj.12003
  • ISSN : 1344-3941
  • Web of Science ID : WOS:000317938900006

エクスポート
BibTeX RIS