2020年10月26日
Drp1 Tubulates the ER in a GTPase-Independent Manner.
Molecular cell
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 80
- 号
- 4
- 開始ページ
- 621
- 終了ページ
- 632
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.molcel.2020.10.013
Mitochondria are highly dynamic organelles that continuously grow, divide, and fuse. The division of mitochondria is crucial for human health. During mitochondrial division, the mechano-guanosine triphosphatase (GTPase) dynamin-related protein (Drp1) severs mitochondria at endoplasmic reticulum (ER)-mitochondria contact sites, where peripheral ER tubules interact with mitochondria. Here, we report that Drp1 directly shapes peripheral ER tubules in human and mouse cells. This ER-shaping activity is independent of GTP hydrolysis and located in a highly conserved peptide of 18 amino acids (termed D-octadecapeptide), which is predicted to form an amphipathic α helix. Synthetic D-octadecapeptide tubulates liposomes in vitro and the ER in cells. ER tubules formed by Drp1 promote mitochondrial division by facilitating ER-mitochondria interactions. Thus, Drp1 functions as a two-in-one protein during mitochondrial division, with ER tubulation and mechano-GTPase activities.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.molcel.2020.10.013
- PubMed ID : 33152269
- PubMed Central 記事ID : PMC7680448