論文

2022年11月7日

Delayed sleep-wake rhythm is associated with cognitive dysfunction, social dysfunction, and deteriorated quality of life in patients with major depressive disorder

Frontiers in Psychiatry
  • Yoshikazu Takaesu
  • ,
  • Yuta Kanda
  • ,
  • Yu Nagahama
  • ,
  • Ayano Shiroma
  • ,
  • Miho Ishii
  • ,
  • Tasuku Hashimoto
  • ,
  • Koichiro Watanabe

13
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.3389/fpsyt.2022.1022144
出版者・発行元
Frontiers Media SA

Background

The delayed sleep-wake phase is commonly observed in major depressive disorder (MDD) and thought to be associated with functional impairments. This study aimed to evaluate the relationship between the delayed sleep-wake phase, cognitive dysfunction, social dysfunction, and quality of life in patients with MDD.

Methods

This cross-sectional design included 33 outpatients with MDD. Objective sleep-wake rhythm was assessed by actigraphy. Functional impairments were evaluated by the Japanese version of the Brief Assessment of Cognition in Schizophrenia (BACS-J), World Health Organization Disability Assessment Schedule (WHO-DAS), and Euro QOL 5 dimensions (EQ5D).

Results

Actigraphic assessment of the delayed sleep-wake phase (midpoint of sleep) was significantly correlated with the composite score of the BACS-J (r = –0.489, p = 0.010), WHO-DAS score (r = 0.466, p = 0.014), and EQ5D score (r = 0.472, p = 0.013). No significant correlation was found between the other actigraphic sleep parameters (sleep latency, total sleep time, and sleep efficiency) and functional impairments.

Conclusion

Our study’s results suggested that the delayed sleep-wake phase is associated with cognitive dysfunction, social dysfunction, and deteriorated quality of life in patients with MDD. Clinicians should pay attention to the sleep-wake rhythm in patients with MDD in clinical settings.

リンク情報
DOI
https://doi.org/10.3389/fpsyt.2022.1022144
URL
https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1022144/full
ID情報
  • DOI : 10.3389/fpsyt.2022.1022144
  • eISSN : 1664-0640

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