takafumi inoue

J-GLOBAL         Last updated: Mar 1, 2019 at 07:49
 
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Name
takafumi inoue
Affiliation
Waseda University
Section
Department of Life Science and Medical Bioscience, Faculty of Science and Engineering
Job title
Professor
Degree
M.D., Ph.D.
ORCID ID
0000-0002-2728-0060

Academic & Professional Experience

 
Apr 2007
 - 
Today
Professor, Department of Lifescience and Medical Bioscience, School of Science and Engineering, Waseda University
 
Dec 1999
 - 
Mar 2007
Associate Professor, Department of Molecular Neurobiology, The Institute of Medical Science, The University of Tokyo
 
Jul 1998
 - 
Nov 1999
Research Fellow, Department of Physiology, New York Medical College
 
Sep 1994
 - 
Nov 1999
Research Fellow, The Institute of Medical Science, The University of Tokyo
 

Education

 
Apr 1988
 - 
Mar 1992
Graduate school (School of Medicine), Osaka University
 
Apr 1982
 - 
Mar 1988
School of Medicine, Keio University
 

Published Papers

 
Hideaki Kubotera, Hiroko Ikeshima-Kataoka, Yoshiki Hatashita, Anna Letizia Allegra Mascaro, Francesco Pavone, Takafumi Inoue
Scientific Reports   in press(1) 1263   Feb 2019   [Refereed]
Takafumi Inoue
Microscopy   67(3) 129   Jun 2018   [Refereed][Invited]
Morteza Heidarinejad, Hideki Nakamura, Takafumi Inoue
Neuroscience Research      Jan 2018
© 2018 Elsevier B.V. and Japan Neuroscience Society. Calcium/calmodulin-dependent protein kinase II (CaMKII) and calmodulin (CaM) play essential roles in synaptic plasticity, which is an elementary process of learning and memory. In this study, fl...
Bozong Xu, Ayumi Kumazawa, Ayumi Kumazawa, Shunsuke Kobayashi, Shin Ichi Hisanaga, Takafumi Inoue, Toshio Ohshima
Developmental Neurobiology   77 1175-1187   Oct 2017
© 2017 Wiley Periodicals, Inc. Cyclin-dependent kinase 5 (Cdk5) is recognized as a unique member among other Cdks due to its versatile roles in many biochemical processes in the nervous system. The proper development of neuronal dendrites is requi...
Kaori Kanemaru, Yoshikazu Nakamura, Yoshikazu Nakamura, Kengo Totoki, Takatsugu Fukuyama, Madoka Shoji, Hisae Kaneko, Kanako Shiratori, Atsuko Yoneda, Atsuko Yoneda, Takafumi Inoue, Yoichiro Iwakura, Kenji Kabashima, Kiyoko Fukami, Kiyoko Fukami
Cell Death and Differentiation   24 1079-1090   Jun 2017
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Keratinocytes undergo a unique type of programmed cell death known as cornification, which leads to the formation of the stratum corneum (SC), the main physical bar...
Haruki Odaka, Haruki Odaka, Tadahiro Numakawa, Tadahiro Numakawa, Aya Yoshimura, Shingo Nakajima, Shingo Nakajima, Naoki Adachi, Naoki Adachi, Yoshiko Ooshima, Yoshiko Ooshima, Takafumi Inoue, Hiroshi Kunugi
Neuroscience Research   113 28-36   Dec 2016
© 2016 Elsevier Ireland Ltd and Japan Neuroscience Society Growing evidence suggests that excess glucocorticoids (GCs) exposure during the pregnancy results in behavioral abnormality in offspring. Although research using animal models has demonstr...
Masaru Ishibashi, Iryna Gumenchuk, Kenichi Miyazaki, Takafumi Inoue, William N. Ross, Christopher S. Leonard
Journal of Neuroscience   36 10097-10115   Sep 2016
© 2016 the authors. Orexins (hypocretins) are neuropeptides that regulate multiple homeostatic processes, including reward and arousal, in part by exciting serotonergic dorsal raphe neurons, the major source of forebrain serotonin. Here, using mou...
Junya Toba, Miyu Nikkuni, Masato Ishizeki, Aya Yoshii, Naoto Watamura, Takafumi Inoue, Toshio Ohshima
Biochemical and Biophysical Research Communications   473 1039-1044   May 2016
© 2016 Elsevier Inc. All rights reserved. Alzheimer's disease (AD) is one of the best known neurodegenerative diseases; it causes dementia and its pathological features include accumulation of amyloid β (Aβ) and neurofibrillary tangles (NFTs) in t...
Nasrin Shafeghat, Nasrin Shafeghat, Morteza Heidarinejad, Noboru Murata, Hideki Nakamura, Hideki Nakamura, Takafumi Inoue
Journal of Neuroscience Methods   263 48-56   Apr 2016
© 2016 Elsevier B.V. Background: Knowledge about the distribution, strength, and direction of synaptic connections within neuronal networks are crucial for understanding brain function. Electrophysiology using multiple electrodes provides a very h...
Takanobu Nakazawa, Takanobu Nakazawa, Takanobu Nakazawa, Ryota Hashimoto, Ryota Hashimoto, Kazuto Sakoori, Yuki Sugaya, Asami Tanimura, Yuki Hashimotodani, Kazutaka Ohi, Hidenaga Yamamori, Hidenaga Yamamori, Yuka Yasuda, Satomi Umeda-Yano, Yuji Kiyama, Kohtarou Konno, Takeshi Inoue, Kazumasa Yokoyama, Takafumi Inoue, Shusuke Numata, Tohru Ohnuma, Nakao Iwata, Norio Ozaki, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Masahiko Watanabe, Toshiya Manabe, Tadashi Yamamoto, Tadashi Yamamoto, Masatoshi Takeda, Masatoshi Takeda, Masanobu Kano
Nature Communications   7    Feb 2016
Intracellular trafficking of receptor proteins is essential for neurons to detect various extracellular factors during the formation and refinement of neural circuits. However, the precise mechanisms underlying the trafficking of neurotrophin rece...
Xiaohua Jin, Kodai Sasamoto, Jun Nagai, Yuki Yamazaki, Kenta Saito, Yoshio Goshima, Takafumi Inoue, Toshio Ohshima
Neural Plasticity   2016    Jan 2016
© 2016 Xiaohua Jin et al. Proper density and morphology of dendritic spines are important for higher brain functions such as learning and memory. However, our knowledge about molecular mechanisms that regulate thedevelopment and maintenance of den...
Takafumi Inoue, Keishi Narita, Yuta Nonami, Hideki Nakamura, Sen Takeda
Journal of Visualized Experiments   2015    Jul 2015
© 2015 Journal of Visualized Experiments. The choroid plexus is located in the ventricular wall of the brain, the main function of which is believed to be production of cerebrospinal fluid.Choroid plexus epithelial cells (CPECs) covering the surfa...
Keishi Narita, Shohei Sasamoto, Schuichi Koizumi, Shizuka Okazaki, Hideki Nakamura, Takafumi Inoue, Sen Takeda
FASEB Journal   29 2247-2259   Jun 2015
© FASEB. The diffusion of materials from systemic circulation to the central nervous system (CNS) is restricted by the blood-brain barrier (BBB) and the bloodcerebrospinal fluid barrier (BCSFB). Choroid plexus epithelial cells (CPECs) of the brain...
Mitsumasa Homma, Yoshiaki Takei, Atsushi Murata, Takafumi Inoue, Shinji Takeoka
Chemical Communications   51 6194-6197   Apr 2015
© The Royal Society of Chemistry 2015. Mitochondrial thermodynamics is the key to understand cellular activities related to homeostasis and energy balance. Here, we report the first ratiometric fluorescent molecular probe (Mito-RTP) that is select...
Vinicius Nikolaos Samios, Takafumi Inoue
Neuroscience Research   87 16   Oct 2014   [Refereed]
Haruki Odaka, Haruki Odaka, Satoshi Arai, Takafumi Inoue, Tetsuya Kitaguchi
PLoS ONE   9    Jun 2014
Cyclic AMP is a ubiquitous second messenger, which mediates many cellular responses mainly initiated by activation of cell surface receptors. Various Förster resonance energy transfer-based ratiometric cAMP indicators have been created for monitor...
Haruki Odaka, Haruki Odaka, Tadahiro Numakawa, Tadahiro Numakawa, Naoki Adachi, Naoki Adachi, Yoshiko Ooshima, Shingo Nakajima, Shingo Nakajima, Yusuke Katanuma, Yusuke Katanuma, Takafumi Inoue, Hiroshi Kunugi, Hiroshi Kunugi
PLoS ONE   9    Jun 2014
Several lines of evidence demonstrate that oxidative stress is involved in the pathogenesis of neurodegenerative diseases, including Parkinson's disease. Potent antioxidants may therefore be effective in the treatment of such diseases. Cabergoline...
Xiaojuan He, Masato Ishizeki, Naoki Mita, Seitaro Wada, Yoshifumi Araki, Hiroo Ogura, Manabu Abe, Maya Yamazaki, Kenji Sakimura, Katsuhiko Mikoshiba, Takafumi Inoue, Toshio Ohshima
Journal of Neurochemistry   131 53-64   Jan 2014
© 2014 International Society for Neurochemistry. Previous studies have implicated the role of Purkinje cells in motor learning and the underlying mechanisms have also been identified in great detail during the last decades. Here we report that cyc...
Yuki Kuwabara, Masato Ishizeki, Naoto Watamura, Junya Toba, Aya Yoshii, Takafumi Inoue, Toshio Ohshima, Toshio Ohshima
Journal of Neurochemistry   130 432-443   Jan 2014
Alzheimer's disease (AD) is a neurodegenerative disorder that represents the most common type of dementia among elderly people. Amyloid beta (Aβ) peptides in extracellular Aβ plaques, produced from the amyloid precursor protein (APP) via sequentia...
Yusuke Katanuma, Yusuke Katanuma, Tadahiro Numakawa, Tadahiro Numakawa, Naoki Adachi, Naoki Adachi, Noriko Yamamoto, Yoshiko Ooshima, Odaka Haruki, Odaka Haruki, Inoue Takafumi, Hiroshi Kunugi, Hiroshi Kunugi
Synapse   68 257-265   Jan 2014
Downregulation of brain-derived neurotrophic factor (BDNF), a member of neurotrophin family, has been implicated in psychiatric diseases including schizophrenia. However, detailed mechanisms of its reduction in patients with schizophrenia remain u...
Yumiko Aoshima, Ryosuke Hokama, Keitaro Sou, Satya Ranjan Sarker, Kabuto Iida, Hideki Nakamura, Takafumi Inoue, Shinji Takeoka
ACS Chemical Neuroscience   4 1514-1519   Dec 2013
The delivery of specific genes into neurons offers a potent approach for treatment of diseases as well as for the study of neuronal cell biology. Here we investigated the capabilities of cationic amino acid based lipid assemblies to act as nonvira...
Yuta Nonami, Keishi Narita, Hideki Nakamura, Takafumi Inoue, Sen Takeda
Cytoskeleton   70 797-803   Dec 2013
Cilia have crucial roles in various developmental and physiological events. Previously, we reported that choroid plexus epithelial cells (CPECs) have multiple, nonmotile 9+0 cilia, but the cilia exhibit transient motility with variable axonemal ar...
Yoshiaki Takei, Atsushi Murata, Kento Yamagishi, Satoshi Arai, Hideki Nakamura, Takafumi Inoue, Shinji Takeoka
Chemical Communications   49 7313-7315   Aug 2013
The powerful strategy of "intracellular click reaction" was used to retain a chemical Ca2+indicator in the cytosol. Specifically, a novel clickable Ca2+indicator "N3-fura-2 AM" was coupled with dibenzylcyclooctyl-modified biomacromolecules via cop...
Takanari Inoue, Takanari Inoue, Yu Chun Lin, Pawel Niewiadomski, Pawel Niewiadomski, Benjamin Lin, Benjamin Lin, Hideki Nakamura, Siew Cheng Phua, John Jiao, Andre Levchenko, Takafumi Inoue, Rajat Rohatgi
Nature Chemical Biology   9 437-443   Jul 2013
Primary cilia function as specialized compartments for signal transduction. The stereotyped structure and signaling function of cilia inextricably depend on the selective segregation of molecules in cilia. However, the fundamental principles gover...
Sarker S.R, Aoshima Y, Hokama R, Inoue T, Sou K, Takeoka S.
International Journal of Nanomedicine   8 1361-1375   2013   [Refereed]
Kumazawa A, Mita N, Hirasawa M, Adachi T, Suzuki H, Shafeghat N, Kulkarni A.B, Mikoshiba K, Inoue T, Ohshima T.
Molecular and Cellular Neuroscience   52 97-105   2013   [Refereed]
Leuner K, Li W, Amaral M.D, Rudolph S, Calfa G, Schuwald A.M, Harteneck C, Inoue T, Pozzo-Miller L.
Hippocampus   23(1) 40-52   2013   [Refereed]
Hikichi T, Matoba R, Ikeda T, Watanabe A, Yamamoto T, Yoshitake S, Tamura-Nakano M, Kimura T, Kamon M, Shimura M, Kawakami K, Okuda A, Okochi H, Inoue T, Suzuki A, Masui S.
Proceedings of the National Academy of Sciences of the United States of America   110(16) 6412-6417   2013   [Refereed]
Keishi Narita, Hiroko Kozuka-Hata, Yuta Nonami, Hiroko Ao-Kondo, Toshimitsu Suzuki, Hideki Nakamura, Kazuhiro Yamakawa, Masaaki Oyama, Takafumi Inoue, Sen Takeda
Biology Open   1 815-825   Aug 2012
© 2012 Published by The Company of Biologists Ltd. Cilia are structurally and functionally diverse organelles, whose malfunction leads to ciliopathies. While recent studies have uncovered common ciliary transport mechanisms, limited information is...
Nakamura H, Bannai H, Inoue T, Michikawa T, Sano M, Mikoshiba K.
Journal of Biological Chemistry   287(29) 24563-24572   2012   [Refereed]
Calfa G, Chapleau C.A, Campbell S, Inoue T, Morse S.J, Lubin F.D, Pozzo-Miller L.
Hippocampus   22(7) 1493-1500   2012   [Refereed]
Tamamushi S, Nakamura T, Inoue T, Ebisui E, Sugiura K, Bannai H, Mikoshiba K.
Neuroscience Research   74(1) 32-41   2012   [Refereed]
Kanda S, Harita Y, Shibagaki Y, Sekine T, Igarashi T, Inoue T, Hattori S.
Molecular Biology of the Cell   22(11) 1824-1835   2011   [Refereed]
Khoo N.K.H, White C.R, Pozzo-Miller L, Zhou F, Constance C, Inoue T, Patel R.P, Parks D.A.
Free Radical Biology and Medicine   49(3) 339-347   2010   [Refereed]
Li Y, Calfa G, Inoue T, Amaral M.D, Pozzo-Miller L.
Journal of Neurophysiology   103(5) 2846-2856   2010   [Refereed]
Katsumata K, Nishiyama J, Inoue T, Mizushima N, Takeda J, Yuzaki M.
Autophagy   6(3) 378-385   2010   [Refereed]
Matsumura T, Oyama M, Kozuka-Hata H, Ishikawa K, Inoue T, Muta T, Semba K, Inoue J.-I.
Biochemical and Biophysical Research Communications   400(2) 265-270   2010   [Refereed]
Fukatsu K, Bannai H, Inoue T, Mikoshiba K.
Journal of Neurochemistry   114(6) 1720-1733   2010   [Refereed]
Bannai H, Lévi S, Schweizer C, Inoue T, Launey T, Racine V, Sibarita J.-B, Mikoshiba K, Triller A.
Neuron   62(5) 670-682   2009   [Refereed]
Taniguchi S, Nakazawa T, Tanimura A, Kiyama Y, Tezuka T, Watabe A.M, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy N.P, Hashimoto K, Kano M, Manabe T, Yamamoto T.
EMBO Journal   28(23) 3717-3729   2009   [Refereed]
Shiba K, Baba S.A, Inoue T, Yoshida M.
Proceedings of the National Academy of Sciences of the United States of America   105(49) 19312-19317   2008   [Refereed]
Fukatsu K, Bannai H, Inoue T, Mikoshiba K.
Biochemical and Biophysical Research Communications   342(2) 573-576   2006   [Refereed]
Matsu-ura T, Michikawa T, Inoue T, Miyawaki A, Yoshida M, Mikoshiba K.
Journal of Cell Biology   173(5) 755-765   2006   [Refereed]
Hisatsune C, Kuroda Y, Akagi T, Torashima T, Hirai H, Hashikawa T, Inoue T, Mikoshiba K.
Journal of Neuroscience   26(42) 10916-10924   2006   [Refereed]
Kodama H, Inoue T, Watanabe R, Yasutomi D, Kawakami Y, Ogawa S, Mikoshiba K, Ikeda Y, Kuwana M.
Immunology and Cell Biology   84(2) 209-217   2006   [Refereed]
Goto J.-I, Inoue T, Kuruma A, Mikoshiba K.
Neuroscience Research   55(1) 28-33   2006   [Refereed]
Kodama H, Inoue T, Watanabe R, Yasuoka H, Kawakami Y, Ogawa S, Ikeda Y, Mikoshiba K, Kuwana M.
Stem Cells and Development   14(6) 676-686   2005   [Refereed]
Tateishi Y, Hattori M, Nakayama T, Iwai M, Bannai H, Nakamura T, Michikawa T, Inoue T, Mikoshiba K.
Journal of Biological Chemistry   280(8) 6816-6822   2005   [Refereed]
Iwai M, Tateishi Y, Hattori M, Mizutani A, Nakamura T, Futatsugi A, Inoue T, Furuichi T, Michikawa T, Mikoshiba K.
Journal of Biological Chemistry   280(11) 10305-10317   2005   [Refereed]
Otsu K, Kuruma A, Yanagida E, Shoji S, Inoue T, Hirayama Y, Uematsu H, Hara Y, Kawano S.
Cell Calcium   37(2) 137-151   2005   [Refereed]
Cai W, Hisatsune C, Nakamura K, Nakamura T, Inoue T, Mikoshiba K.
Journal of Biological Chemistry   279(22) 23691-23698   2004   [Refereed]
Bannai H, Fukatsu K, Mizutani A, Natsume T, Iemura S.-I, Ikegami T, Inoue T, Mikoshiba K.
Journal of Biological Chemistry   279(51) 53427-53434   2004   [Refereed]
Hattori M, Suzuki A.Z, Higo T, Miyauchi H, Michikawa T, Nakamura T, Inoue T, Mikoshiba K.
Journal of Biological Chemistry   279(12) 11967-11975   2004   [Refereed]
Fukatsu K, Bannai H, Zhang S, Nakamura H, Inoue T, Mikoshiba K.
Journal of Biological Chemistry   279(47) 48976-48982   2004   [Refereed]
Hisatsune C, Kuroda Y, Nakamura K, Inoue T, Nakamura T, Michikawa T, Mizutani A, Mikoshiba K.
Journal of Biological Chemistry   279(18) 18887-18894   2004   [Refereed]
Ismailov I, Kalikulov D, Inoue T, Friedlander M.J.
Journal of Neuroscience   24(44) 9847-9861   2004   [Refereed]
Kohlmeier K.A, Inoue T, Leonard C.S.
Journal of Neurophysiology   92(1) 221-235   2004   [Refereed]
Bannai H, Inoue T, Nakayama T, Hattori M, Mikoshiba K.
Journal of Cell Science   117(2) 163-175   2004   [Refereed]
Nakayama T, Hattori M, Uchida K, Nakamura T, Tateishi Y, Bannai H, Iwai M, Michikawa T, Inoue T, Mikoshiba K.
Biochemical Journal   377(2) 299-307   2004   [Refereed]
Kuruma A, Inoue T, Mikoshiba K.
European Journal of Neuroscience   18(10) 2677-2689   2003   [Refereed]
Inoue T.
Keio Journal of Medicine   52(4) 244-249   2003   [Refereed]
Yasuda H, Higashi H, Kudo Y, Inoue T, Hata Y, Mikoshiba K, Tsumoto T.
European Journal of Neuroscience   17(2) 287-297   2003   [Refereed]
Minoshima Y, Kawashima T, Hirose K, Tonozuka Y, Kawajiri A, Bao Y.C, Deng X, Tatsuka M, Narumiya S, May Jr. W.S, Nosaka T, Semba K, Inoue T, Satoh T, Inagaki M, Kitamura T.
Developmental Cell   4(4) 549-560   2003   [Refereed]
Nagase T, Ito K.-I, Kato K, Kaneko K, Kohda K, Matsumoto M, Hoshino A, Inoue T, Fujii S, Kato H, Mikoshiba K.
Neuroscience   117(4) 821-830   2003   [Refereed]
Fukami K, Yoshida M, Inoue T, Kurokawa M, Fissore R.A, Yoshida N, Mikoshiba K, Takenawa T.
Journal of Cell Biology   161(1) 79-88   2003   [Refereed]
Fukami K, Inoue T, Kurokawa M, Fissore R.A, Nakao K, Nagano K, Nakamura Y, Takenaka K, Yoshida N, Mikoshiba K, Takenawa T.
Advances in Enzyme Regulation   43 87-106   2003   [Refereed]
Inoue T, Lin X, Kohlmeier K.A, Orr H.T, Zoghbi H.Y, Ross W.N.
Journal of Neurophysiology   85(4) 1750-1760   2001   [Refereed]
Aihara Y, Inoue T, Tashiro T, Okamoto K, Komiya Y, Mikoshiba K.
Journal of Neuroscience Research   65(3) 236-246   2001   [Refereed]
Fukami K, Nakao K, Inoue T, Kataoka Y, Kurokawa M, Fissore R.A, Nakamura K, Katsuki M, Mikoshiba K, Yoshida N, Takenawa T.
Science   292(5518) 920-923   2001   [Refereed]
Kume S, Inoue T, Mikoshiba K.
Developmental Biology   226(1) 88-103   2000   [Refereed]
Leonard C.S, Rao S.R, Inoue T.
Journal of Neurophysiology   84(3) 1558-1572   2000   [Refereed]
Pozzo-Miller L.D, Inoue T, Murphy D.D.
Journal of Neurophysiology   81(3) 1404-1411   1999   [Refereed]
Hayashi M, Monkawa T, Yoshida T, Sasamura H, Matsumoto M, Inoue T, Mikoshiba K, Saruta T.
Journal of the American Society of Nephrology   10(10) 2094-2101   1999   [Refereed]
Umemori H, Hayashi T, Inoue T, Nakanishi S, Mikoshiba K, Yamamoto T.
Oncogene   18(51) 7399-7402   1999   [Refereed]
Takei K, Shin R.-M, Inoue T, Kato K, Mikoshiba K.
Science   282(5394) 1705-1708   1998   [Refereed]
Yoshida M, Sensui N, Inoue T, Morisawa M, Mikoshiba K.
Developmental Biology   203(1) 122-133   1998   [Refereed]
Inoue T, Kato K, Kohda K, Mikoshiba K.
Journal of Neuroscience   18(14) 5366-5373   1998   [Refereed]
Umemori H, Inoue T, Kume S, Sekiyama N, Nagao M, Itoh H, Nakanishi S, Mikoshiba K, Yamamoto T.
Science   276(5320) 1878-1881   1997   [Refereed]
Kume S, Yamamoto A, Inoue T, Muto A, Okano H, Mikoshiba K.
Developmental Biology   182(2) 228-239   1997   [Refereed]
Hisatsune C, Umemori H, Inoue T, Michikawa T, Kohda K, Mikoshiba K, Yamamoto T.
Journal of Biological Chemistry   272(33) 20805-20810   1997   [Refereed]
Kume S, Muto A, Inoue T, Suga K, Okano H, Mikoshiba K.
Science   278(5345) 1940-1943   1997   [Refereed]
Matsumoto M, Nakagawa T, Inoue T, Nagata E, Tanaka K, Takano H, Minowa O, Kuno J, Sakakibara S, Yamada M, Yoneshima H, Miyawaki A, Fukuuchi Y, Furuichi T, Okano H, Mikoshiba K, Noda T.
Nature   379(6561) 168-171   1996   [Refereed]
Muto A, Kume S, Inoue T, Okano H, Mikoshiba K.
Journal of Cell Biology   135(1) 181-190   1996   [Refereed]
Matheson J.M, Miyawaki A, Muto A, Inoue T, Mikoshiba K.
Biomedical Research   17(3) 221-225   1996   [Refereed]
Kohda K, Inoue T, Mikoshiba K.
Journal of Neurophysiology   74(5) 2184-2188   1995   [Refereed]
Ito K.-i, Miura M, Furuse H, Zhixiong C, Kato H, Yasutomi D, Inoue T, Mikoshiba K, Kimura T, Sakakibara S, Miyakawa H.
Neuroscience Letters   183(1-2) 112-115   1995   [Refereed]
Inoue T, Miyakawa H, Ito K.-I, Mikoshiba K, Kato H.
Neuroscience Research   15(4) 265-271   1992   [Refereed]
Tamura T, Aoyama A, Inoue T, Miura M, Mikoshiba M.
Journal of General Virology   71(8) 1829-1833   1990   [Refereed]
Inoue T, Tamura T, Furuichi T, Mikoshiba K.
Journal of Biological Chemistry   265(31) 19065-19070   1990   [Refereed]
Tamura T.-A, Aoyama A, Inoue T, Miura M, Okano H, Mikoshiba K.
Molecular and Cellular Biology   9(7) 3122-3126   1989   [Refereed]
Preparation of large amounts of transcription-competent nuclear extracts from mouse brain
Taka-aki Tamura, Yasuko Ohya, Masayuki Miura, Atsuo Aoyama, Takafumi Inoue, Katsuhiko Mikoshiba
Technique   1 33-36   1989   [Refereed]
Tamura T, Inoue T, Nagata K, Mikoshiba K
Biochemical and biophysical research communications   157(2) 419-425   Dec 1988   [Refereed]

Conference Activities & Talks

 
井上貴文
万有製薬株式会社若手研究者のための薬理学セミナー要旨集   31 Oct 2003   
Katsuhiko Mikoshiba, Katsuhiko Mikoshiba, Katsuhiko Mikoshiba, Takafumi Inoue, Takafumi Inoue, Akira Futatsugi, Akira Futatsugi, Akira Futatsugi, Satoshi Fujii, Hiroshi Kato
International Congress Series   1 Oct 2003   
IP3is an important second messenger to release Ca2+from internal store. IP3receptor (IP3R) works as an IP3-induced Ca2+release channel. We studied the role of type 1 IP3R (IP3R1) in neural plasticity. We found that IP3R1 is necessary for the induc...
Yoko Takiyama, Kunio Kato, Takafumi Inoue, Fumihiko Sakai, Katsuhiko Mikoshiba, Katsuhiko Mikoshiba, Katsuhiko Mikoshiba, Katsuhiko Mikoshiba
International Congress Series   1 Jul 2002   
Electrophysiological studies have shown that decreases in extracellular Ca2+concentration and increases in extracellular K+concentration cause non-synaptic seizure-like neuronal activity in the hippocampus. Using the calcium imaging technique, we ...
Yoshida M, Sensui N, Inoue T, Morisawa M, Mikoshiba K.
Zygote   1998   
Inoue T, Miyakawa H, Ito K.-I, Mikoshiba K, Kato H.
Annals of the New York Academy of Sciences   1993   

Research Grants & Projects

 
文部科学省: 科学研究費補助金(挑戦的萌芽研究)
Project Year: 2014 - 2016    Investigator(s): 井上 貴文
独自に開発したランダムスキャン型二光子励起顕微鏡システムを用い、脳切片中の神経細胞の膜電位計測を同時多点で行うことを目的とした。複数培養神経細胞から同時に計測した活動電位記録のスパイク抽出アルゴリズムと時系列の細胞間の比較アルゴリズムを開発し、ソフトウェアに実装し、神経細胞のシナプス結合の有無および結合の方向性について解析を行うことに成功した。脳切片中の神経細胞の膜電位感受性色素を用いた染色法の開発に成功し、これら神経細胞の活動電位計測に成功した。
文部科学省: 科学研究費補助金(基盤研究(B))
Project Year: 2011 - 2013    Investigator(s): 井上 貴文
新規に開発した2光子励起顕微鏡システムを用い多点で同時に蛍光相関分光法(FCS)を適用することにより、1) 神経細胞樹状突起の細胞質中を高速に移動するタンパク質分子の動態を捉えること、および2) 神経細胞の膜電位計測を同時多点で行うことを目的とした。GFP発現プラスミドあるいはGFP融合CamKIIタンパク質発現プラスミドをマウス由来初代培養神経細胞に発現させ細胞質の複数点から蛍光強度変化の記録を10kHz以上の時間解像度で取得しFCS解析することに成功した。また、複数培養神経細胞から同時...
文部科学省: 科学研究費補助金(挑戦的萌芽研究)
Project Year: 2010 - 2012    Investigator(s): 井上 貴文
新規に開発した2光子励起顕微鏡システムを用い多点で同時に蛍光相関分光法(FCS)を適用することにより神経細胞樹状突起の細胞質中を高速に移動するタンパク質分子の動態を捉えることを目的とした。GFP発現プラスミドあるいはGFP融合CamKIIタンパク質発現プラスミドをマウス由来初代培養神経細胞に発現させ細胞質の複数点から蛍光強度変化の記録を10kHz以上の時間解像度で取得しFCS解析することに成功した。

Misc

 
友池史明, 山岡和樹, 伊藤真央, 木村康明, 井上貴文, 阿部洋
日本化学会春季年会講演予稿集(CD-ROM)   98th ROMBUNNO.1D5‐44   Mar 2018
小高陽樹, 沼川忠広, 曽我美南, 城戸淳, 梶原隆太郎, 奥宮敏可, 古谷博和, 井上貴文, 江良拓実
日本先天代謝異常学会雑誌   33 187   Sep 2017
足立透真, 足立透真, 宮下聡, 山下真梨子, 井上貴文, 星野幹雄
日本生化学会大会(Web)   90th ROMBUNNO.3P‐0827 (WEB ONLY)   2017
SATO Akira, MUNEMURA Nobuyuki, SANO Yoshitake, SHINODA Yo, SADAKATA Tetsushi, MORITA Noriyuki, YUZAKI Michisuke, INOUE Takafumi, HASHIMOTO Mitsuhiro, OHWADA Hayato, NISHIBE Hirozumi, YAMAGUCHI Yoko, FURUICHI Teiichi
Program & Abstracts. 4th INCF Japan Node International Workshop. Advances in Neuroinformatics 2016 and 14th INCF Nodes Workshop, 2016   49   2016
足立透真, 足立透真, 宮下聡, 井上貴文, 星野幹雄
日本生物学的精神医学会(Web)   38th 130 (WEB ONLY)   2016
足立透真, 足立透真, 宮下聡, 井上貴文, 星野幹雄
日本分子生物学会年会プログラム・要旨集(Web)   39th ROMBUNNO.2P‐0532 (WEB ONLY)   2016
寺田泰比古, 森勇介, 谷山ゆき, 井上陽子, 中村秀樹, 井上貴文, 成田啓之, 竹田扇
日本細胞生物学会大会要旨集   67th 110   Jun 2015
NARITA Keishi, SASAMOTO Shohei, KOIZUMI Schuichi, OKAZAKI Shizuka, NAKAMURA Hideki, INOUE Takafumi, TAKEDA Sen
Journal of Physiological Sciences   65(Supplement 1) S203   2015
SATO Akira, SHINODA Yo, SADAKATA Tetsushi, MORITA Noriyuki, YUZAKI Michisuke, INOUE Takafumi, NISHIBE Hirozumi, YAMAGUCHI Yoko, FURUICHI Teiichi
Program & Abstracts. INCF Japan Node International Workshop: Advances in Neuroinformatics, 2015   42   2015
武井義明, 村田篤, 山岸健人, 新井敏, 中村秀樹, 井上貴文, 武岡真司
日本化学会講演予稿集   94th(4) 1429   Mar 2014
ODAKA Haruki, NUMAKAWA Tadahiro, ADACHI Naoki, OSHIMA Toshiko, NAKAJIMA Shingo, KATANUMA Yusuke, INOUE Takafumi, KUNUGI Hiroshi
日本生物学的精神医学会誌   147   2014
SAMIOS Vinicius Nikolaos, INOUE Takafumi
J Physiol Sci   64(Supplement 1) S143   2014
TOBA Junya, YOSHII Aya, KUWABARA Yuki, ISHIZEKI Masato, INOUE Takafumi, OHSHIMA Toshio
日本分子生物学会年会プログラム・要旨集(Web)   37th 2P-0678 (WEB ONLY)   2014
ODAKA Haruki, ARAI Satoshi, INOUE Takafumi, KITAGUCHI Tetsuya
日本分子生物学会年会プログラム・要旨集(Web)   37th 3P-0903 (WEB ONLY)   2014
谷山ゆき, 森勇介, 岸田尚樹, 山中翔太, 井上陽子, 新美貴大, 中村秀樹, 井上貴文, 成田啓之, 竹田扇, 寺田泰比古
日本分子生物学会年会プログラム・要旨集(Web)   37th 3P-0391 (WEB ONLY)   2014
森勇介, 堂田怜香, 岸田尚樹, 山中翔太, 谷山ゆき, 青木聡美, 中村秀樹, 井上貴文, 武田直也, 寺田泰比古
日本分子生物学会年会プログラム・要旨集(Web)   36th 3P-0418 (WEB ONLY)   2013
裏田亜里沙, 中村秀樹, 井上貴文, 武田直也
日本バイオマテリアル学会シンポジウム予稿集   2012 282-282   Nov 2012
青島由美子, SARKER Satya Ranjan, 井上貴文, 武岡真司
日本バイオマテリアル学会大会予稿集   33rd 213-213   Nov 2011
青島由美子, SARKER S. R., 平川貴彬, 井上貴文, 武岡真司
日本化学会講演予稿集   91st(3) 711   Mar 2011
神田祥一郎, 張田豊, 関根孝司, 五十嵐隆, 井上貴文, 服部成介
日本小児科学会雑誌   115(2) 366-366   Feb 2011
アストロサイトの一次線毛によるカルシウムシグナルの調節機構(Primary cilium regulates Ca2+ signalling in astrocytes)
垣沼 直人, 荒井 祐輔, 井上 貴文, 竹田 扇
神経化学   49(2-3) 531-531   Aug 2010
神田祥一郎, 張田豊, 関根孝司, 五十嵐隆, 井上貴文, 服部成介
日本小児腎臓病学会雑誌   23(1) 131-131   Jun 2010
井上貴文
脳機能の統合的研究 平成16-21年度 No.16067101   68-69   2010
KANDA Shoichiro, HARITA Yutaka, SEKINE Takashi, SHIBAGAKI Yoshio, IGARASHI Takashi, INOUE Takafumi, HATTORI Seisuke
日本分子生物学会年会講演要旨集   32nd(Vol.4) 131   2009
Fukatsu Kazumi, Bannai Hiroko, Inoue Takafumi, Mikoshiba Katsuhiko
Seibutsu Butsuri   48(0)    2008
Bannai Hiroko, Levi Sabine, Schweizer Claude, Inoue Takafumi, Launey Thomas, Racine Victor, Sibarita Jean-Baptiste, Mikoshiba Katsuhiko, Triller Antoine
Seibutsu Butsuri   48(0)    2008
小川健夫, 広瀬寛, 税所芳史, 矢島賢, 井上貴文, 御子柴克彦
糖尿病   49(Supplement 1) S.326   Apr 2006
松浦徹, 道川貴章, 道川貴章, 井上貴文, 宮脇敦史, 吉田学, 御子柴克彦
日本分子生物学会年会講演要旨集   28th 554   Nov 2005
Kuruma Akinori, Inoue Takafumi, Goto Jun-ichi, Futatsugi Akira, Mikoshiba Katsuhiko
Proc Annu Meet PSJ   2005(0) S148-S148   2005
Mice homozygous for targeted disruption of the α1A subunit of the voltage gated Ca channel (PQKO) show fatal ataxia and dystonia. We investigated properties of the cerebellar Purkinje cell (PC) in PQKO (P14-20) using acute cerebellar slices....
Goto Jun-Ichi, Inoue Takafumi, Kuruma Akinori, Mikoshiba Katsuhiko
Proc Annu Meet PSJ   2005(0) S149-S149   2005
Long-term depression (LTD) of the parallel fiber (PF)–Purkinje cell (PC) synapse is an underlying mechanism by which motor coordination and learning are regulated. Elevation of cytoplasmic calcium in the PC dendrites is a critical event for ...
Fukatsu K., Bannai H., Zhang S., Nakamura H., Inoue T., Mikoshiba K.
Seibutsu Butsuri   44(1)    Nov 2004
Bannai H., Fukatsu K., Mizutani A., Natsume T., Iemura S., Ikegami T., Inoue T., Mikoshiba K.
Seibutsu Butsuri   44(1)    Nov 2004
井上貴文
神経疾患の分子機構の解明と治療法開発に関する研究 平成14-16年度 総括研究報告書   37-38   2004
立石陽子, 服部光治, 坂内博子, 岩井美和子, 内田敬子, 中村健, 道川貴章, 井上貴文, 御子柴克彦
日本分子生物学会年会プログラム・講演要旨集   26th 744   Nov 2003
Bannai H., Inoue T., Nakayama T., Hattori M., Mikoshiba K.
Seibutsu Butsuri   43(1)    Aug 2003
Fukatsu K., Bannai H., Zhang S., Inoue T., Mikoshiba K.
Seibutsu Butsuri   43(1)    Aug 2003
神経疾患の分子機構の解明と治療法開発に関する研究 神経細胞樹状突起におけるカルシウム動態
井上 貴文
厚生労働省精神・神経疾患研究委託費研究報告集   平成14年度 552-552   Jun 2003
Mikoshiba K, Inoue T, Futatsugi A, Fujii S, Kato H
COGNITION AND EMOTION IN THE BRAIN   1250 461-472   2003   [Refereed]
井上貴文
脳研究の総合的推進に関する研究 平成13年度採択公募班員   5   2003
Mikoshiba Katsuhiko, Hamada Kozo, Bannai Hiroko, Fukatsu Kazumi, Ando Hideaki, Matsuura Toru, Uchida Keiko, Michikawa Takayuki, Nakayama Tomohiro, Tateishi Yoko, Zhang Songba, Mizutani Akihiro, Hattori Mitsuharu, Inoue Takafumi
Seibutsu Butsuri   43(0)    2003
井上貴文
厚生労働省精神・神経疾患研究委託費による研究報告集 平成14年度 (2年度班・初年度班)   552   2003
坂内博子, 井上貴文, 中山智博, 服部光治, 御子柴克彦
日本生物物理学会年会講演予稿集   40th S113   Nov 2002
黒倉あゆ子, 井上貴文, 山田麻紀, 御子柴克彦
日本神経科学大会プログラム・抄録集   25th 130   Jul 2002
後藤純一, 井上貴文, 来馬明規, 御子柴克彦
日本神経科学大会プログラム・抄録集   25th 180   Jul 2002
来馬明規, 井上貴文, 御子柴克彦
日本神経科学大会プログラム・抄録集   25th 181   Jul 2002
神経疾患の分子生物学的病態解明研究 小脳プルキンエ細胞におけるイノシトール3リン酸受容体の生理機能
井上 貴文
厚生省精神・神経疾患研究委託費による研究報告集   平成12年度 443-443   Mar 2002
生後3〜4月のSCA1マウス及びコントロールの野生型マウスより小脳切片を定法により作成し,正立顕微鏡下で直視化にてプルキンエ細胞の細胞体よりパッチクランプ法により電気記録をとり,同時にカルシウム色素bis-fura-2を細胞内に導入し,冷却CCDカメラを用いて細胞内カルシウム濃度を測定した.顕著に萎縮したSCA1マウスのプルキンエ細胞においても電気生理学的特徴の多くは保存されていたことから,これらは単にプルキンエ細胞の樹状突起の形態的特徴に基づくものではなく,他の要素によることがわかった....
Dynamics of Ca2+ and Na+ in cerebellar Purkinje cells
Kuruma A, Inoue T, Mikoshiba K
BIOPHYSICAL JOURNAL   82(1) 648A   Jan 2002   [Refereed]
Bannai H., Inoue T., Nakayama T., Hattori M., Mikoshiba K.
Seibutsu Butsuri   42(2)    2002
井上貴文
Clinical Calcium   11(11) 1409-1416   Nov 2001
相原優子, 岡本幸市, 井上貴文, 御子柴克彦
臨床神経学   40(12) 1359-1359   Dec 2000