Gou Takahashi

Profile Information

Affiliation: Assistant Professor, Department of Animal Science, Faculty of Agriculture, Tokyo University of Agriculture

Degree: 生物産業学（博士）(東京農業大学)

Researcher number: 70802817
ORCID iD: https://orcid.org/0000-0003-2277-7657
J-GLOBAL ID: 202101021052162140
researchmap Member ID: R000018805

Research Interests

Research Areas

Life sciences / Laboratory animal science /

Research History

May, 2024 - Present

Tokyo Metropolitan Institute of Medical Science
Apr, 2024 - Present

Faculty of Agriculture, Tokyo University of Agriculture
Apr, 2017 - Mar, 2024

Staff Scientist, Regenerative Medicine Project, Tokyo Metropolitan Institute of Medical Science

Education

Apr, 2014 - Mar, 2017

Department of Bio-industry, Graduate School of Bio-industry, Tokyo University of Agriculture
Apr, 2012 - Mar, 2014

Department of Bioproduction, Graduate School of Bio-industry, Tokyo University of Agriculture
Apr, 2008 - Mar, 2012

Department of Bio-production, Faculty of Bio-industry, Tokyo University of Agriculture

Awards

2017

Experimental Animals Best Paper Award, A novel missense mutation of Mip causes semi-dominant cataracts in the Nat mouse

Papers

High-throughput robotic isolation of human iPS cell clones reveals frequent homozygous induction of identical genetic manipulations by CRISPR-Cas9

Gou Takahashi, Minato Maeda, Kayoko Shinozaki, Gakuro Harada, Saburo Ito, Yuichiro Miyaoka

Sep 19, 2024
Fusion of histone variants to Cas9 suppresses non-homologous end joining.

Tomoko Kato-Inui, Gou Takahashi, Terumi Ono, Yuichiro Miyaoka

PloS one, 19(5) e0288578, 2024
Large-scale single-cell cloning of genome-edited cultured human cells by On-chip SPiS.

Gou Takahashi, Yuichiro Miyaoka

STAR protocols, 4(3) 102364-102364, Jun 16, 2023
Genome editing is induced in a binary manner in single human cells.

Gou Takahashi, Daiki Kondo, Minato Maeda, Yuji Morishita, Yuichiro Miyaoka

iScience, 25(12) 105619-105619, Dec 22, 2022
Gender-Difference in Hair Length as Revealed by Crispr-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations.

Ryo Takahashi, Gou Takahashi, Yuichi Kameyama, Masahiro Sato, Masato Ohtsuka, Kenta Wada

International journal of molecular sciences, 23(19), Oct 6, 2022
Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in Wilson’s disease-specific hepatocytes

Dan Song, Gou Takahashi, Yun-Wen Zheng, Mami Matsuo-Takasaki, Jingyue Li, Miho Takami, Yuri An, Yasuko Hemmi, Natsumi Miharada, Tsuyoshi Fujioka …

Human Molecular Genetics, 31(21) 3652-3671, Apr 7, 2022
Rapid, precise quantification of large DNA excisions and inversions by ddPCR.

Hannah L Watry, Carissa M Feliciano, Ketrin Gjoni, Gou Takahashi, Yuichiro Miyaoka, Bruce R Conklin, Luke M Judge

Scientific reports, 10(1) 14896-14896, Sep 10, 2020
Thy1 promoter activity in the Rosa26 locus in mice: lessons from Dre-rox conditional expression system.

Saaki Tamura, Yukiko Yasuoka, Hiromi Miura, Gou Takahashi, Masahiro Sato, Masato Ohtsuka

Experimental animals, 69(3) 287-294, Aug 5, 2020
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 with improved proof-reading enhances homology-directed repair.

Tomoko Kato-Inui, Gou Takahashi, Szuyin Hsu, Yuichiro Miyaoka

Nucleic acids research, 46(9) 4677-4688, May 18, 2018
Pde6brd1 mutation modifies cataractogenesis in Foxe3rct mice.

Kenta Wada, Junichi Saito, Midori Yamaguchi, Yuta Seki, Masamune Furugori, Gou Takahashi, Yasumasa Nishito, Hiroshi Matsuda, Hiroshi Shitara, Yoshiaki Kikkawa

Biochemical and biophysical research communications, 496(1) 231-237, Jan 29, 2018
A novel missense mutation of Mip causes semi-dominant cataracts in the Nat mouse.

Gou Takahashi, Sayaka Hasegawa, Yukiko Fukutomi, Chihiro Harada, Masamune Furugori, Yuta Seki, Yoshiaki Kikkawa, Kenta Wada

Experimental animals, 66(3) 271-282, Aug 5, 2017
GONAD and Easy (Isi)-CRISPR: novel mouse genome engineering tools

Masato Ohtsuka, Hiromi Miura, Gou Takahashi, Rolen Quadros, Masahiro Sato, Channabasavaiah B. Gurumurthy

TRANSGENIC RESEARCH, 25(2) 214-215, Apr, 2016 Peer-reviewed
GONAD: A Novel CRISPR/Cas9 Genome Editing Method that Does Not Require Ex Vivo Handling of Embryos.

Channabasavaiah B Gurumurthy, Gou Takahashi, Kenta Wada, Hiromi Miura, Masahiro Sato, Masato Ohtsuka

Current protocols in human genetics, 88 15.8.1-15.8.12, Jan 1, 2016
GONAD: Genome-editing via Oviductal Nucleic Acids Delivery system: a novel microinjection independent genome engineering method in mice.

Gou Takahashi, Channabasavaiah B Gurumurthy, Kenta Wada, Hiromi Miura, Masahiro Sato, Masato Ohtsuka

Scientific reports, 5 11406-11406, Jun 22, 2015
Mouse Genome Editing Using the CRISPR/Cas System.

Donald W Harms, Rolen M Quadros, Davide Seruggia, Masato Ohtsuka, Gou Takahashi, Lluis Montoliu, Channabasavaiah B Gurumurthy

Current protocols in human genetics, 83 15.7.1-27, Oct 1, 2014
Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice.

Kenta Wada, Yoshibumi Matsushima, Tomoki Tada, Sayaka Hasegawa, Yo Obara, Yasuhiro Yoshizawa, Gou Takahashi, Hiroshi Hiai, Midori Shimanuki, Sari Suzuki …

PloS one, 9(10) e111432, 2014
A deletion in a cis element of Foxe3 causes cataracts and microphthalmia in rct mice.

Kenta Wada, Yukiko Y Maeda, Kei Watanabe, Tatsuya Oshio, Takuya Ueda, Gou Takahashi, Michinari Yokohama, Junichi Saito, Yuta Seki, Sumiyo Takahama …

Mammalian genome : official journal of the International Mammalian Genome Society, 22(11-12) 693-702, Dec, 2011

Misc.

GONAD:採卵,顕微注入,移植を要しない新規ゲノム編集マウス作製法

大塚正人, GURUMURTHY Channabasavaiah, 三浦浩美, 佐藤正宏, 和田健太, 高橋剛

J Reprod Dev, 61(Suppl.) j152-j152, Sep, 2015

Books and Other Publications

ゲノム編集の最新技術と医薬品・遺伝子治療・農業・水畜産物・有用物質生産への活用

技術情報協会 (Role: Contributor)

技術情報協会, Aug, 2023 (ISBN: 9784861049781)

Professional Memberships

Research Projects

Cas12の連続的編集による高効率な欠失導入法の確立

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2025 - Mar, 2028

高橋剛
細胞種により異なる倍数性の意義をiPS細胞モデルにより追究する

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2024 - Mar, 2027

宮岡佑一郎, 加藤朋子, 高橋剛
マウスの交配のように自在なヒトiPS細胞間の遺伝子交換手法の開発

科学研究費助成事業, 挑戦的研究(萌芽), 日本学術振興会, Jun, 2024 - Mar, 2026

宮岡佑一郎, 加藤朋子, 高橋剛
医療応用可能なCRISPR-Cas12aによる欠失導入法の確立

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2022 - Mar, 2025

高橋剛
医療応用のための非ランダムなゲノム編集技術の開発

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2023

宮岡佑一郎, 加藤朋子, 高橋剛
Establishment of a precise deletion mutagenesis method using CRISPR/Cpf1 to enable gene therapy

Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

TAKAHASHI Gou
白内障発症マウス突然変異体natの表現型解析および原因遺伝子の同定に基づく新規白内障モデルマウスの開発

平成26年度笹川科学研究助成, 公益財団法人日本科学協会, Apr, 2014 - Mar, 2015

Profile Information

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Education

Awards

Papers

Misc.

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