論文

査読有り 本文へのリンクあり
2018年9月

Lung-resident natural killer cells control pulmonary tumor growth in mice

Cancer Science
  • Yutaka Yamamoto
  • ,
  • Kiho Miyazato
  • ,
  • Kei Takahashi
  • ,
  • Naoki Yoshimura
  • ,
  • Hideaki Tahara
  • ,
  • Yoshihiro Hayakawa

109
9
開始ページ
2670
終了ページ
2676
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/cas.13703

Accumulating evidence indicates the importance of natural killer (NK) cells in controlling tumor growth and metastasis. NK cell subsets display diversities in their function and tissue distribution and Mac-1hi CD27lo NK cells are the predominant population of lung-resident NK cells. Although the lung is a major organ where primary tumor develops and cancer cells metastasize, there is no clear evidence whether circulating NK cells and/or tissue-resident NK cells control tumor growth in the lung. In the present study, we examined an antitumor function of lung-resident NK cells to control pulmonary tumor growth. In an orthotopic lung tumor model, NK cells controlled pulmonary tumor growth, and mature circulating NK cell subsets were increased in tumor-bearing lungs through a C-X-C motif chemokine receptor 3 (CXCR3)-dependent mechanism. Although such increase in migratory NK cell subsets can be blocked by anti-CXCR3 treatment, there was no difference in pulmonary tumor growth in anti-CXCR3-treated mice compared with control mice. In addition to pulmonary tumor growth, lung-resident NK cells, but not migratory NK cells, play a dominant role in controlling metastatic growth of cancer cells in lung. These results strongly indicate an importance of lung-resident NK cells for controlling pulmonary tumor growth.

リンク情報
DOI
https://doi.org/10.1111/cas.13703
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29927042
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85050873302&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85050873302&origin=inward
ID情報
  • DOI : 10.1111/cas.13703
  • ISSN : 1347-9032
  • eISSN : 1349-7006
  • PubMed ID : 29927042
  • SCOPUS ID : 85050873302

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