論文

査読有り 本文へのリンクあり 国際誌
2021年

Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation

Nature Communications
  • Sau Yee Kok
  • ,
  • Hiroko Oshima
  • ,
  • Kei Takahashi
  • ,
  • Mizuho Nakayama
  • ,
  • Kazuhiro Murakami
  • ,
  • Hiroki R. Ueda
  • ,
  • Kohei Miyazono
  • ,
  • Masanobu Oshima

12
1
開始ページ
863
終了ページ
863
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41467-021-21160-0

A concept of polyclonal metastasis has recently been proposed, wherein tumor cell clusters break off from the primary site and are disseminated. However, the involvement of driver mutations in such polyclonal mechanism is not fully understood. Here, we show that non-metastatic AP cells metastasize to the liver with metastatic AKTP cells after co-transplantation to the spleen. Furthermore, AKTP cell depletion after the development of metastases results in the continuous proliferation of the remaining AP cells, indicating a role of AKTP cells in the early step of polyclonal metastasis. Importantly, AKTP cells, but not AP cells, induce fibrotic niche generation when arrested in the sinusoid, and such fibrotic microenvironment promotes the colonization of AP cells. These results indicate that non-metastatic cells can metastasize via the polyclonal metastasis mechanism using the fibrotic niche induced by malignant cells. Thus, targeting the fibrotic niche is an effective strategy for halting polyclonal metastasis.

リンク情報
DOI
https://doi.org/10.1038/s41467-021-21160-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33558489
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870854
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85101172847&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85101172847&origin=inward
ID情報
  • DOI : 10.1038/s41467-021-21160-0
  • eISSN : 2041-1723
  • PubMed ID : 33558489
  • PubMed Central 記事ID : PMC7870854
  • SCOPUS ID : 85101172847

エクスポート
BibTeX RIS