論文

査読有り 国際誌
2014年11月

Identification of Hirsutine as an anti-metastatic phytochemical by targeting NF-κB activation.

International journal of oncology
  • Chenghua Lou
  • ,
  • Kei Takahashi
  • ,
  • Tatsuro Irimura
  • ,
  • Ikuo Saiki
  • ,
  • Yoshihiro Hayakawa

45
5
開始ページ
2085
終了ページ
91
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3892/ijo.2014.2624

Nuclear factor-κB (NF-κB) activation has been implicated not only in carcinogenesis but also in cancer cell invasion and metastatic process; therefore, targeting the NF-κB pathway is an attractive strategy for controlling meta-stasis. Amongst 56 chemically defined compounds derived from natural products, we have identified a new phytochemical compound Hirsutine, which strongly suppresses NF-κB activity in murine 4T1 breast cancer cells. In accordance with the NF-κB inhibition, Hirsutine reduced the metastatic potential of 4T1 cells, as seen in the inhibition of the migration and invasion capacity of 4T1 cells. Hirsutine further inhibited the constitutive expression of MMP-2 and MMP-9 in 4T1 cells, and reduced the in vivo lung metastatic potential of 4T1 cells in the experimental model. Given that the migration of human breast cancer cells was also inhibited, our present study implies that Hirsutine is an attractive phytochemical compound for reducing metastasis potential of cancer cells by regulating tumor-promoting NF-κB activity.

リンク情報
DOI
https://doi.org/10.3892/ijo.2014.2624
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25175557
ID情報
  • DOI : 10.3892/ijo.2014.2624
  • PubMed ID : 25175557

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