Kei Takahashi-Yamashiro

Tissue clearing method in visualization of cancer progression and metastasis

Kei Takahashi-Yamashiro, Kohei Miyazono

Upsala Journal of Medical Sciences, 129, Apr 9, 2024 Peer-reviewed

High-Performance Genetically Encoded Green Fluorescent Biosensors for Intracellular l-Lactate.

Saaya Hario, Giang N T Le, Hikaru Sugimoto, Kei Takahashi-Yamashiro, Suguru Nishinami, Hirofumi Toda, Selene Li, Jonathan S Marvin, Shinya Kuroda, Mikhail Drobizhev …

ACS central science, 10(2) 402-416, Feb 28, 2024 Peer-reviewed

Biosensor Optimization Using a Förster Resonance Energy Transfer Pair Based on mScarlet Red Fluorescent Protein and an mScarlet-Derived Green Fluorescent Protein.

Khyati Gohil, Sheng-Yi Wu, Kei Takahashi-Yamashiro, Yi Shen, Robert E Campbell

ACS sensors, Jan 24, 2023 Peer-reviewed

The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to metabolically adapt mitochondria

Arthur Bassot, Junsheng Chen, Kei Takahashi-Yamashiro, Megan C. Yap, Christine Silvia Gibhardt, Giang N.T. Le, Saaya Hario, Yusuke Nasu, Jack Moore, Tomas Gutiérrez …

Cell Reports, 42(1) 111899-111899, Jan, 2023 Peer-reviewed

Quantification of Intracellular Citrate Concentrations with Genetically Encoded Biosensors

Yufeng Zhao, Kei Takahashi-Yamashiro, Yi Shen, Robert E. Campbell

Methods in Molecular Biology, 247-258, Sep 16, 2022

An analysis modality for vascular structures combining tissue-clearing technology and topological data analysis.

Kei Takahashi, Ko Abe, Shimpei I Kubota, Noriaki Fukatsu, Yasuyuki Morishita, Yasuhiro Yoshimatsu, Satoshi Hirakawa, Yoshiaki Kubota, Tetsuro Watabe, Shogo Ehata …

Nature communications, 13(1) 5239-5239, Sep 12, 2022 Peer-reviewedLead author

Visualization of the cancer cell cycle by tissue‐clearing technology using the Fucci reporter system

Kei Takahashi, Ryo Tanabe, Shogo Ehata, Shimpei I. Kubota, Yasuyuki Morishita, Hiroki R. Ueda, Kohei Miyazono

Cancer Science, 112(9) 3796-3809, Jul 7, 2021 Peer-reviewedLead author

Establishment of bioluminescent imaging model using murine T cell lymphoma susceptive to NK cell-dependent immune-surveillance

Toshiyuki Fujiwara, Kiho Miyazato, Kei Takahashi, Yoshihiro Hayakawa

Journal of Immunological Methods, 491 112993-112993, Apr, 2021 Peer-reviewed

Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing

Shimpei I. Kubota, Kei Takahashi, Tomoyuki Mano, Katsuhiko Matsumoto, Takahiro Katsumata, Shoi Shi, Kazuki Tainaka, Hiroki R. Ueda, Shogo Ehata, Kohei Miyazono

Communications Biology, 4(1), Mar 5, 2021 Peer-reviewed

Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation

Sau Yee Kok, Hiroko Oshima, Kei Takahashi, Mizuho Nakayama, Kazuhiro Murakami, Hiroki R. Ueda, Kohei Miyazono, Masanobu Oshima

Nature Communications, 12(1), Feb 8, 2021 Peer-reviewed

Protocol for Imaging and Analysis of Mouse Tumor Models with CUBIC Tissue Clearing

Kei Takahashi, Shimpei I. Kubota, Shogo Ehata, Hiroki R. Ueda, Kohei Miyazono

STAR Protocols, 1(3) 100191-100191, Dec 18, 2020 Peer-reviewedLead author

Neurotensin receptor 1 signaling promotes pancreatic cancer progression

Kei Takahashi, Shogo Ehata, Kensuke Miyauchi, Yasuyuki Morishita, Keiji Miyazawa, Kohei Miyazono

Molecular Oncology, 15(1) 151-166, Nov 20, 2020 Peer-reviewedLead author

Epigenetic remodelling shapes inflammatory renal cancer and neutrophil-dependent metastasis

Jun Nishida, Yusaku Momoi, Kosuke Miyakuni, Yusuke Tamura, Kei Takahashi, Daizo Koinuma, Kohei Miyazono, Shogo Ehata

Nature Cell Biology, 22(4) 465-475, Mar 23, 2020 Peer-reviewed

Tyrosine kinase Eph receptor A6 sensitizes glioma-initiating cells towards bone morphogenetic protein-induced apoptosis

Erna Raja, Masato Morikawa, Jun Nishida, Ryo Tanabe, Kei Takahashi, Howard J. Seeherman, Nobuhito Saito, Tomoki Todo, Kohei Miyazono

Cancer Science, 110(11) 3486-3496, Nov 1, 2019 Peer-reviewed

Palbociclib enhances activin‐SMAD‐induced cytostasis in estrogen receptor‐positive breast cancer

Mayumi Harada, Masato Morikawa, Takayuki Ozawa, Mai Kobayashi, Yusuke Tamura, Kei Takahashi, Masahiko Tanabe, Keiichiro Tada, Yasuyuki Seto, Kohei Miyazono …

Cancer Science, 110(1) 209-220, Nov 16, 2018 Peer-reviewed

Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents

Kazuki Tainaka, Tatsuya C. Murakami, Etsuo A. Susaki, Chika Shimizu, Rie Saito, Kei Takahashi, Akiko Hayashi-Takagi, Hiroshi Sekiya, Yasunobu Arima, Satoshi Nojima …

Cell Reports, 24(8) 2196-2210.e9, Aug 21, 2018 Peer-reviewed

Lung‐resident natural killer cells control pulmonary tumor growth in mice

Yutaka Yamamoto, Kiho Miyazato, Kei Takahashi, Naoki Yoshimura, Hideaki Tahara, Yoshihiro Hayakawa

Cancer Science, 109(9) 2670-2676, Jul 12, 2018 Peer-reviewed

Pancreatic tumor microenvironment confers highly malignant properties on pancreatic cancer cells

Kei Takahashi, Shogo Ehata, Daizo Koinuma, Yasuyuki Morishita, Manabu Soda, Hiroyuki Mano, Kohei Miyazono

Oncogene, 37(21) 2757-2772, May 1, 2018 Peer-reviewedLead author

ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y 12 in platelets

Miki Kamiyama, Toshiaki Shirai, Shogo Tamura, Katsue Suzuki-Inoue, Shogo Ehata, Kei Takahashi, Kohei Miyazono, Yoshihiro Hayakawa, Takehiro Sato, Kohsuke Takeda …

Cell Death and Differentiation, 24(12) 2066-2076, Dec 1, 2017 Peer-reviewed

Proteasome Inhibitor–Loaded Micelles Enhance Antitumor Activity Through Macrophage Reprogramming by NF-κB Inhibition

Hailiang Wu, Anqi Tao, John D. Martin, Sabina Quader, Xueying Liu, Kei Takahashi, Louise Hespel, Yutaka Miura, Yoshihiro Hayakawa, Tatsuro Irimura …

Journal of Pharmaceutical Sciences, 106(9) 2438-2446, Sep, 2017 Peer-reviewed

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