Takaji Wakita

Profile Information

Degree: 医学博士

J-GLOBAL ID: 201901003008307290
researchmap Member ID: B000360967

Research Areas

Life sciences / Virology /

Papers

521

Overcoming antibody-resistant SARS-CoV-2 variants with bispecific antibodies constructed using non-neutralizing antibodies

Tetsuya Inoue, Yuichiro Yamamoto, Kaoru Sato, Yuko Okemoto-Nakamura, Yoshimi Shimizu, Motohiko Ogawa, Taishi Onodera, Yoshimasa Takahashi, Takaji Wakita, Mika K. Kaneko …

iScience, 27(4) 109363-109363, Apr, 2024
Mpox Neutralizing Antibody Response to LC16m8 Vaccine in Healthy Adults.

Eriko Morino, Sohtaro Mine, Noriko Tomita, Yukari Uemura, Yosuke Shimizu, Sho Saito, Tetsuya Suzuki, Nobumasa Okumura, Haruka Iwasaki, Junko Terada …

NEJM evidence, 3(3) EVIDoa2300290, Mar, 2024
Hepatocellular organellar abnormalities following elimination of hepatitis C virus.

Haruyo Aoyagi, Hiroko Iijima, Eman S Gaber, Takuma Zaitsu, Mami Matsuda, Kosho Wakae, Koichi Watashi, Ryosuke Suzuki, Takahiro Masaki, Jeffrey Kahn …

Liver international : official journal of the International Association for the Study of the Liver, 43(8) 1677-1690, Aug, 2023
Hepatitis C Virus Disrupts Annexin 5-Mediated Occludin Integrity through Downregulation of Protein Kinase Cα (PKCα) and PKCη Expression, Thereby Promoting Viral Propagation.

Takayuki Abe, Yuki Marutani, Lin Deng, Chieko Matsui, Masayoshi Fukasawa, Ryosuke Suzuki, Takaji Wakita, Yoshiharu Matsuura, Ikuo Shoji

Journal of virology, 97(6) e0065523, Jun 5, 2023
A Multicenter Randomized Controlled Trial To Evaluate the Efficacy and Safety of Nelfinavir in Patients with Mild COVID-19.

Taiga Miyazaki, Naoki Hosogaya, Yuri Fukushige, Sachiko Takemori, Shinpei Morimoto, Hiroshi Yamamoto, Makoto Hori, Yoshihito Ozawa, Yuki Shiko, Yosuke Inaba …

Microbiology spectrum, 11(3) e0431122, May 4, 2023
N6-methyladenosine Modification of Hepatitis B Virus RNA in the Coding Region of HBx.

Takayuki Murata, Satoko Iwahori, Yusuke Okuno, Hironori Nishitsuji, Yusuke Yanagi, Koichi Watashi, Takaji Wakita, Hiroshi Kimura, Kunitada Shimotohno

International journal of molecular sciences, 24(3), Jan 23, 2023
Identification of neutralizing epitopes in the preS2 domain of the hepatitis B virus.

Keigo Yato, Mami Matsuda, Kento Fukano, Tomohisa Tanaka, Kohji Moriishi, Hironori Nishitsuji, Kunitada Shimotohno, Koji Tamura, Takaji Wakita, Masamichi Muramatsu …

Virus research, 323 199014-199014, Jan 2, 2023
National seroepidemiological study of COVID‐19 after the initial rollout of vaccines: Before and at the peak of the Omicron‐dominant period in Japan

Takeshi Arashiro, Satoru Arai, Ryo Kinoshita, Kanako Otani, Sho Miyamoto, Daisuke Yoneoka, Taro Kamigaki, Hiromizu Takahashi, Hiromi Hibino, Mai Okuyama …

Influenza and Other Respiratory Viruses, 17(2), Jan, 2023 Peer-reviewed
Direct Inhibition of SARS-CoV-2 Spike Protein by Peracetic Acid.

Yuichiro Yamamoto, Yoshio Nakano, Mana Murae, Yoshimi Shimizu, Shota Sakai, Motohiko Ogawa, Tomoharu Mizukami, Tetsuya Inoue, Taishi Onodera, Yoshimasa Takahashi …

International journal of molecular sciences, 24(1), Dec 20, 2022
Independent evolution of multi-dominant viral genome species observed in a hepatitis C virus carrier.

Tomomi Ando, Hideki Aizaki, Masaya Sugiyama, Tomoko Date, Kazuhiko Hayashi, Masatoshi Ishigami, Yoshiaki Katano, Hidemi Goto, Masashi Mizokami, Masamichi Muramatsu …

Biochemistry and biophysics reports, 32 101327-101327, Dec, 2022
SEB genotyping: SmartAmp-Eprimer binary code genotyping for complex, highly variable targets applied to HBV

Diane Delobel, Yutaka Furutani, Sumiko Nagoshi, Akihito Tsubota, Akio Miyasaka, Koichi Watashi, Takaji Wakita, Tomokazu Matsuura, Kengo Usui

BMC Infectious Diseases, 22(1), Dec, 2022
A single mutation in the E2 glycoprotein of hepatitis C virus broadens the claudin specificity for its infection.

Yoshitaka Shirasago, Hidesuke Fukazawa, Shotaro Nagase, Yoshimi Shimizu, Tomoharu Mizukami, Takaji Wakita, Tetsuro Suzuki, Hideki Tani, Masuo Kondoh, Takuya Kuroda …

Scientific reports, 12(1) 20243-20243, Nov 24, 2022
エンテカビル耐性B型肝炎ウイルスポリメラーゼの生化学的および構造学的性質

中嶋章悟, 渡士幸一, 加藤孝宣, 村松正道, 脇田隆字, 安武義晃, 豊田哲也

日本生化学会大会プログラム・講演要旨集, 95回 2T08a-09, Nov, 2022
Development and Use of a Kinetical and Real-Time Monitoring System to Analyze the Replication of Hepatitis C Virus

Xiaoyu Li, Masahiko Ito, Haruyo Aoyagi, Asako Murayama, Hideki Aizaki, Masayoshi Fukasawa, Takanobu Kato, Takaji Wakita, Tetsuro Suzuki

International Journal of Molecular Sciences, 23(15) 8711-8711, Aug 5, 2022
Genome-wide CRISPR screen for HSV-1 host factors reveals PAPSS1 contributes to heparan sulfate synthesis.

Takeshi Suzuki, Yoshitaka Sato, Yusuke Okuno, Fumi Goshima, Tadahisa Mikami, Miki Umeda, Takayuki Murata, Takahiro Watanabe, Koichi Watashi, Takaji Wakita …

Communications biology, 5(1) 694-694, Jul 19, 2022
Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action

Masaaki Toyama, Koichi Watashi, Masanori Ikeda, Atsuya Yamashita, Mika Okamoto, Kohji Moriishi, Masamichi Muramatsu, Takaji Wakita, Ashoke Sharon, Masanori Baba

Antimicrobial Agents and Chemotherapy, May 23, 2022
Structural insights into the HBV receptor and bile acid transporter NTCP.

Jae-Hyun Park, Masashi Iwamoto, Ji-Hye Yun, Tomomi Uchikubo-Kamo, Donghwan Son, Zeyu Jin, Hisashi Yoshida, Mio Ohki, Naito Ishimoto, Kenji Mizutani …

Nature, 606(7916) 1027-1031, May 17, 2022
Hepatitis C Virus-Induced ROS/JNK Signaling Pathway Activates the E3 Ubiquitin Ligase Itch to Promote the Release of HCV Particles via Polyubiquitylation of VPS4A.

Lin Deng, Yujiao Liang, Adi Ariffianto, Chieko Matsui, Takayuki Abe, Masamichi Muramatsu, Takaji Wakita, Masatoshi Maki, Hideki Shibata, Ikuo Shoji

Journal of virology, 96(6) e0181121, Mar 23, 2022
The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro

Sameh A. Gad, Masaya Sugiyama, Masataka Tsuge, Kosho Wakae, Kento Fukano, Mizuki Oshima, Camille Sureau, Noriyuki Watanabe, Takanobu Kato, Asako Murayama …

PLOS Pathogens, 18(3) e1009983-e1009983, Mar 21, 2022
感染受容体NTCPの多量体化が導くB型肝炎ウイルス細胞内侵入機構の解明

深野顕人, 大嶋美月, 九十田千子, 相崎英樹, 大木規央, 朴三用, 脇田隆字, 若江亨祥, 渡士幸一, 村松正道

日本薬学会年会要旨集, 142年会 26M-pm15, Mar, 2022

Misc.

180

Development of therapeutic agents for hepatitis C viruses using actinomycetes

阿南美穂, 阿南美穂, 渡邉則幸, 中島琢自, 竹山春子, 竹山春子, 相崎英樹, 村松正道, 村松正道, 脇田隆字

日本ウイルス学会学術集会プログラム・予稿集(Web), 70th, 2023
新宿区繁華街におけるいわゆる「接待を伴う飲食店」における新型コロナウイルス感染症の感染リスクに関する調査研究(中間報告)

小林祐介, 有馬雄三, 神谷元, 八幡裕一郎, 山岸拓也, 砂川富正, 鈴木基, 太田雅之, 新城雄士, 鈴木忠樹 …

IASR (Web), 42(1), 2021
エンテカビル耐性B型肝炎ウイルス逆転写酵素の反応速度論的解析

中嶋章悟, 中嶋章悟, 渡士幸一, 渡士幸一, 加藤孝宣, 脇田隆字, 豊田哲也

日本分子生物学会年会プログラム・要旨集(Web), 42nd, 2019
B型肝炎ウイルス(HBV)逆転写伸長反応系を利用したHBV複製阻害剤の同定

中嶋章悟, 中嶋章悟, 渡士幸一, 渡士幸一, 深野顕人, 九十田千子, 九十田千子, 相崎英樹, 村松正道, 脇田隆字 …

日本ウイルス学会学術集会プログラム・予稿集(Web), 67th, 2019
Antiviral effects of second‐generation N55A inhibition evaluated in Hepatitis C virus cell culture system with full‐genome infectious clones

MURAYAMA Asako, FUJIWARA Kei, YAMADA Norie, SHIINA Masaaki, MURAMATSU Masamichi, WAKITA Takaji, KATO Takanobu

日本ウイルス学会学術集会プログラム・抄録集, 66th 229, Sep 18, 2018
Anti‐hepatitis B Virus effects of IFN‐lambda3

KATO Takanobu, YAMADA Norie, MURATA Kazumoto, MURAYAMA Asako, SHIINA Masaaki, MURAMATSU Masamichi, WAKITA Takaji

日本ウイルス学会学術集会プログラム・抄録集, 66th 293, Sep 18, 2018
Generation of monoclonal antibodies against hepatitis B virus preS1 region from antigen‐specific memory B cells

YATO Keigo, YATO Keigo, ONODERA Taishi, MATSUDA Mami, FUJIMOTO Akira, WATASHI Koichi, AIZAKI Hideki, KATO Takanobu, MORIISHI Kohji, TAMURA Koji …

日本ウイルス学会学術集会プログラム・抄録集, 66th 177, Sep 18, 2018
HCV細胞培養系を用いた第二世代NS5A阻害剤の抗ウイルス活性と薬剤耐性変異の解析

村山麻子, 山田典栄, 藤原圭, 村松正道, 脇田隆字, 加藤孝宣

肝臓, 59(Suppl.1) A319-A319, Apr, 2018
Induction of humoural and cellular immunity by immunisation with HCV particle vaccine in a non-human primate model

Hiroshi Yokokawa, Hiroshi Yokokawa, Atsunori Higashino, Atsunori Higashino, Saori Suzuki, Saori Suzuki, Masaki Moriyama, Noriko Nakamura, Tomohiko Suzuki, Ryosuke Suzuki …

Gut, 67(2) 372-379, Feb 1, 2018
HCVの遺伝子型2aのウイルス株を用いた新規HCV感染増殖系の樹立

村山麻子, 鈴木亮介, 脇田隆字, 加藤孝宣

生命科学系学会合同年次大会, 2017年度 [3LBA-112], Dec, 2017
HBV‐X regulates its own mRNA half life to evade apoptosis

HUSEIN Aly, WATASHI Koichi, WATANABE Noriyuki, SAYAMA Kazuaki, KATO Takanobu, WAKITA Takaji

肝臓, 58(Supplement 3) A909, Nov 5, 2017
Identification of a new class of HBV and HDV entry inhibitor, proanthocyanidin

Senko Tsukuda, Koichi Watashi, Soichi Kojima, Takaji Wakita

HEPATOLOGY, 66 484A-485A, Oct, 2017
Induction of neutralization E2 antibody by immunization of recombinant E2 proteins

Noriyuki Watanabe, Tomoko Date, Hussein H. Aly, Hideki Aizaki, Takaji Wakita

HEPATOLOGY, 66 466A-466A, Oct, 2017
Fatty acids synthesized from cellular fatty acid synthesis pathway play roles in hepatitis B virus production

OKAMURA Hitomi, NIO Yasunori, WATASHI Koichi, WAKITA Takaji, HIJIKATA Makoto

第65回日本ウイルス学会学術集会．大阪, Oct, 2017
Acute hepatitis in Japan

262(14) 1215-1220, Sep 30, 2017
Generation of hepatitis C virus vaccine antigen based on Japanese encephalitis virus subviral particles

YATO Keigo, YATO Keigo, MATSUDA Mami, WATANABE Noriyuki, NAKAJIMA Shogo, FUJIMOTO Akira, WATASHI Koichi, AIZAKI Hideki, KATO Takanobu, TAMURA Koji …

日本ウイルス学会学術集会プログラム・抄録集, 65th 193, Sep 27, 2017
HCV Lifecycle : The Target of DAA

72(9) 1229-1234, Sep, 2017
Fatty acids with certain carbon chain length can support hepatitis B virus production.

OKAMUARA Hitomi, NIO Yasunori, WATASHI Koichi, WAKITA Takaji, HIJIKATA Makoto

2017 International meeting on the molecular biology of hepatitis B viruses, Washington D.C., USA, Sep, 2017 Peer-reviewed
国内で使用されているC型肝炎ウイルスの体外診断用医薬品を対象とした性能評価

百瀬暖佳, 加藤孝宣, 松岡佐保子, 大隈和, 池辺詠美, 山田典栄, 村山麻子, 豊田九朗, 脇田隆字, 浜口功

日本輸血細胞治療学会誌, 63(3) 408-408, Jun, 2017
検体パネルを用いたHBV DNAおよびHBs抗原検出用体外診断薬の評価

加藤孝宣, 村山麻子, 脇田隆字

肝臓, 58(Suppl.1) A205-A205, Apr, 2017

Research Projects

C型肝炎のDAA治療によるSVR達成後の肝病態形成に関わる基礎的研究

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

脇田隆字
Reversible and irreversible damages of hepatocyte after DAA treatment for HCV carriers

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Wakita Takaji
Analysis of mechanism of HCV particle formation, secretion, and associated cellular factor

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Morikawa Kenichi, WAKITA TAKAJI, DATE TOMOKO, SHIMAZAKI TOMOE
Virus and host interaction on plus-strand RNA virus replication

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2012 - Mar, 2017

WAKITA Takaji
Molecular basis of host cell competency in virus infection

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2012 - Mar, 2017

NAGATA Kyosuke, Park Sam-Yong, Takeyasu Kunio, Takaori Akifumi, Arase Hisashi, Iba Hideo, Koyanagi Yoshio
The mechanism of infection of enterovirus71: through the receptor PSGL-1.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

KATAOKA Chikako, SHIMIZU Hiroyuki, NISHIMURA Yorihiro, WAKITA Takaji, AMI Yasushi, NAGATA Noriyo, SUZUKI Tadaki, IWATA Naoko, KOTANI Osamu
Analysis of hepatitis C virus sequence quasi species by NGS

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2011 - 2012

WAKITA Takaji
Cell culture system for genotype1b hepatitis C virus

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2009 - 2011

WAKITA Takaji
C型肝炎ウイルスの感染増殖および粒子形成における脂質の役割

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2009 - 2010

脇田隆字, 花田賢太郎, 相崎英樹
Analysis of the role of lipid in viral life cycles

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2007 - 2008

WAKITA Taksji, HARADA Kentaro, AIZAKI Hideki
Analysis of factors involved in viral replication efficiency and search for novel anti -virals using HCV culture systems.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2006 - 2008

WAKITA Takaji, DATE Tomoko, MORIKAWA Kenichi, AIZAKI Hideki, MURAKAMI Kyoko, ISHII Koji, SUZUKI Ryosuke
C型肝炎ウイルスの感染初期過程に関与する宿主因子の探索

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2007 - 2007

脇田隆字, 石井孝司, 相崎英樹, 村上恭子, 伊達朋子
Analysis of virus adaptations in the novel HCV cell culture and infection system

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

MURAYAMA Asako, WAKITA Takaji, DATE Tomoko, MORIKAWA Kenichi
感染性C型肝炎ウイルス粒子による肝細胞への遺伝子デリバリーシステムの構築

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2006 - 2007

脇田隆字, 伊達朋子, 森川賢一, 相崎英樹, 村上恭子, 石井孝司, 溝上雅史
Production and Analysis of Chimeric Hepatitis C Virus

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2005 - 2006

DATE Tomoko, WAKITA Takaji, MURAYAMA Asako
HCVレプリコンシステムを用いた薬剤感受性規定領域の検討

科学研究費助成事業, 基盤研究(C), 日本学術振興会, 2004 - 2006

加藤孝宣, 溝上雅史, 脇田隆字, 宮本道子
Analysis of replication of Hepatitis C Virus using highly efficient replication system

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

WAKITA Takaji, MIYAMOTO Michiko, KATO Takanobu
Viral genomic region of Hepatitis C Virus which determine viral replication and drug sensitivity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

MIYAMOTO Michiko, WAKITA Takaji, KATO Takanobu
デングウイルス感染マウスモデルを用いたデング出血熱の病態解析

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2002 - 2003

保井孝太郎, 宮本道子, 加藤孝宣, 脇田隆字
Construction and analysis of viral hepatocarcinogenesis model using HCV transgenic mouse model

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2002 - 2003

WAKITA Takaji, YASUI Kotaro, MIYAMOTO Michiko, KATO Takanobu

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