Takahashi Ken

Profile Information

J-GLOBAL ID: 201301071197136443
researchmap Member ID: B000229888

External link: http://kaken.nii.ac.jp/d/r/60594372.ja.html

Research Areas

Life sciences / Gastroenterology /

Research History

2013

Kyoto University

Papers

Evolutional transition of HBV genome during the persistent infection determined by single-molecule real-time sequencing.

Soichi Arasawa, Haruhiko Takeda, Atsushi Takai, Eriko Iguchi, Yuji Eso, Takahiro Shimizu, Ken Takahashi, Taiki Yamashita, Yoshihide Ueda, Hiroyuki Marusawa …

Hepatology communications, 7(3) e0047, Mar 1, 2023
ミスマッチ修復遺伝子MSH2の欠損は炎症性肝発癌を促進する

中野重治, 高井淳, 上野真行, 網野遙, 井上貴裕, 伊藤卓彦, 寺村茉利, 三嶋眞紗子, 熊谷健, 井口恵里子 …

日本消化器病学会雑誌, 119(臨増大会) A771-A771, Oct, 2022
肝癌の発生・進展過程における体細胞変異の蓄積に、ミスマッチ修復異常(dMMR)はどのように寄与しているか?

上野真行, 竹田治彦, 高井淳, 恵荘裕嗣, 中野重治, 高橋健, 田浦康二朗, 波多野悦朗, 妹尾浩

肝胆膵, 85(1) 148-149, Jul, 2022
Expansion of Gastric Intestinal Metaplasia with Copy Number Aberrations Contributes to Field Cancerization.

Ken Kumagai, Takahiro Shimizu, Atsushi Takai, Nobuyuki Kakiuchi, Yasuhide Takeuchi, Tomonori Hirano, Haruhiko Takeda, Aya Mizuguchi, Mari Teramura, Takahiko Ito …

Cancer research, 82(9) 1712-1723, May 3, 2022
Mutational spectrum of hepatitis C virus in patients with chronic hepatitis C determined by single molecule real-time sequencing.

Fumiyasu Nakamura, Haruhiko Takeda, Yoshihide Ueda, Atsushi Takai, Ken Takahashi, Yuji Eso, Soichi Arasawa, Eriko Iguchi, Takahiro Shimizu, Masako Mishima …

Scientific reports, 12(1) 7083-7083, Apr 30, 2022
Artificial intelligence (AI) models for the ultrasonographic diagnosis of liver tumors and comparison of diagnostic accuracies between AI and human experts.

Naoshi Nishida, Makoto Yamakawa, Tsuyoshi Shiina, Yoshito Mekada, Mutsumi Nishida, Naoya Sakamoto, Takashi Nishimura, Hiroko Iijima, Toshiko Hirai, Ken Takahashi …

Journal of gastroenterology, 57(4) 309-321, Apr, 2022 Peer-reviewed
TERTの過剰発現はNF-κB経路の活性化を介し肝発癌ポテンシャルの上昇に寄与する

三嶋眞紗子, 高井淳, 上野真行, 伊藤卓彦, 寺村茉利, 中野重治, 熊谷健, 井口恵里子, 竹田治彦, 恵荘裕嗣 …

肝臓, 63(Suppl.1) A298-A298, Apr, 2022
好中球リンパ球比(NLR)を活用した切除不能肝細胞癌治療戦略の最適化

恵荘裕嗣, 竹田治彦, 高井淳, 高橋健, 妹尾浩

肝臓, 63(Suppl.1) A347-A347, Apr, 2022
肝がん診断・治療における超音波の役割と進歩 Sonazoid造影超音波を用いた簡便で汎用性の高い腫瘍血流定量評価法の提唱

恵荘裕嗣, 中野重治, 竹田治彦, 高井淳, 高橋健, 妹尾浩

超音波医学, 49(Suppl.) S186-S186, Apr, 2022
Ultrasound-guided polidocanol foam sclerotherapy for symptomatic giant hepatic cyst: a single-center experience.

Yuji Eso, Hironori Shimizu, Atsushi Takai, Ken Takahashi, Hiroshi Seno

Hepatology research : the official journal of the Japan Society of Hepatology, 52(6) 557-565, Mar 31, 2022
In situ vaccination using unique TLR9 ligand K3-SPG induces long-lasting systemic immune response and synergizes with systemic and local immunotherapy.

Hirokazu Okada, Ken Takahashi, Hiroaki Yaku, Kouji Kobiyama, Keiko Iwaisako, Xiangdong Zhao, Masahiro Shiokawa, Norimitsu Uza, Yuzo Kodama, Ken J Ishii …

Scientific reports, 12(1) 2132-2132, Feb 8, 2022
Genetic Landscape of Multistep Hepatocarcinogenesis.

Haruhiko Takeda, Atsushi Takai, Yuji Eso, Ken Takahashi, Hiroyuki Marusawa, Hiroshi Seno

Cancers, 14(3), Jan 23, 2022
Pretreatment Neutrophil-to-Lymphocyte Ratio as a Predictive Marker of Response to Atezolizumab Plus Bevacizumab for Hepatocellular Carcinoma.

Yuji Eso, Haruhiko Takeda, Kojiro Taura, Atsushi Takai, Ken Takahashi, Hiroshi Seno

Current oncology (Toronto, Ont.), 28(5) 4157-4166, Oct 14, 2021
A simplified method to quantitatively predict the effect of lenvatinib on hepatocellular carcinoma using contrast-enhanced ultrasound with perfluorobutane microbubbles

Yuji Eso, Shigeharu Nakano, Masako Mishima, Soichi Arasawa, Eriko Iguchi, Haruhiko Takeda, Atsushi Takai, Ken Takahashi, Hiroshi Seno

Quantitative Imaging in Medicine and Surgery, 11(6) 2766-2774, Jun, 2021
A novel technique for mapping biopsy of bile duct cancer

Hirokazu Okada, Norimitsu Uza, Tomoaki Matsumori, Shimpei Matsumoto, Yuya Muramoto, Sakiko Ota, Takeharu Nakamura, Hiroyuki Yoshida, Tomonori Hirano, Takeshi Kuwada …

Endoscopy, 53(6) 647-651, Jun, 2021 Peer-reviewed
Oncogenic transcriptomic profile is sustained in the liver after the eradication of the hepatitis C virus

Haruhiko Takeda, Atsushi Takai, Eriko Iguchi, Masako Mishima, Soichi Arasawa, Ken Kumagai, Yuji Eso, Takahiro Shimizu, Ken Takahashi, Yoshihide Ueda …

Carcinogenesis, 42(5) 672-684, May 28, 2021
Mac‐2 binding protein glycosylation isomer predicts tolerability and clinical outcome of lenvatinib therapy for hepatocellular carcinoma

Yuji Eso, Shigeharu Nakano, Masako Mishima, Soichi Arasawa, Eriko Iguchi, Haruhiko Takeda, Atsushi Takai, Ken Takahashi, Kojiro Taura, Hiroshi Seno

Journal of Hepato-Biliary-Pancreatic Sciences, Apr 17, 2021
急性膵炎と血球貪食症候群を合併した急性肝不全昏睡型の1例

萬川和, 高井淳, 濱田健輔, 桑田威, 恵荘裕嗣, 高橋健, 妹尾浩

肝臓, 62(Suppl.1) A265-A265, Apr, 2021
ポリドカノールフォームを用いた超音波ガイド下肝嚢胞硬化療法の長期成績

恵荘裕嗣, 中野重治, 三嶋眞紗子, 荒澤壮一, 井口恵理子, 竹田治彦, 高井淳, 高橋健, 妹尾浩

超音波医学, 48(Suppl.) S724-S724, Apr, 2021
Lenvatinib治療経過バイオマーカーとしてのMac-2 binding glycosylation isomer

恵荘裕嗣, 中野重治, 井口恵里子, 荒澤壮一, 竹田治彦, 高井淳, 高橋健, 妹尾浩

肝臓, 62(Suppl.1) A297-A297, Apr, 2021

Misc.

Initial experience and predictors of response to Atezolizumab plus Bevacizumab combination therapy for hepatocellular carcinoma

恵荘裕嗣, 竹田治彦, 高井淳, 高橋健, 妹尾浩

肝胆膵, 84(4), 2022
Conversion surgery after lenvatinib therapy for unresectable hepatocellular carcinoma

西尾太宏, 小山幸法, 小木曾聡, 楊知明, 福光剣, 石井隆道, 恵荘裕嗣, 高井淳, 高橋健, 瀬尾智 …

肝胆膵, 84(4), 2022
Atezolizumab+Bevacizumab奏効後根治的にTACEを追加した一例

恵荘裕嗣, 中野重治, 三嶋眞紗子, 井口恵里子, 竹田治彦, 高井淳, 高橋健, 妹尾浩

日本肝がん分子標的治療研究会プログラム・抄録集, 24th, 2021
多段階発癌におけるミスマッチ修復異常関連体細胞変異シグネチャーの抽出

竹田治彦, 高井淳, 恵荘裕嗣, 高橋健, 田浦康二朗, 波多野悦朗, 喜多竜一, 丸澤宏之, 藤本明洋, 妹尾浩

日本肝がん分子標的治療研究会プログラム・抄録集, 24th, 2021
Atezolizumab+Bevacizumab併用療法の初期治療成績

恵荘裕嗣, 中野重治, 三嶋眞紗子, 井口恵里子, 竹田治彦, 高井淳, 高橋健, 妹尾浩

日本肝がん分子標的治療研究会プログラム・抄録集, 24th, 2021
レンバチニブ治療による肝切除を目指したconversion therapyの可能性の検証

西尾太宏, 小山幸法, 小木曾聡, 楊知明, 福光剣, 石井隆道, 恵荘裕嗣, 高井淳, 高橋健, 瀬尾智 …

日本肝がん分子標的治療研究会プログラム・抄録集, 24th, 2021
Ultrasound-guided sclerotherapy for symptomatic giant hepatic cyst using polidocanol foam

恵荘裕嗣, 中野重治, 三嶋眞紗子, 荒澤壮一, 井口恵理子, 竹田治彦, 高井淳, 高橋健, 妹尾浩

超音波医学 Supplement, 48, 2021
巨大肝嚢胞に対するポリドカノールを用いたfoam sclerotherapyの長期成績

恵荘裕嗣, 中野重治, 三嶋眞紗子, 荒澤壮一, 井口恵里子, 竹田治彦, 高井淳, 高橋健, 妹尾浩

日本消化器病学会雑誌(Web), 118, 2021
体表面積補正Dose intensity(DBR;DI/BSA ratio)に着目した肝細胞癌に対するレンバチニブ導入の最適化

恵荘裕嗣, 高井淳, 高橋健, 妹尾浩

Pharma Medica, 39(2), 2021
IN SITU VACCINE IMMUNOTHERAPY FOR GASTROINTESTINAL CANCERS USING NOVEL NANOPARTICULATE TLR9 AGONIST K3-SPG

Hirokazu Okada, Ken Takahashi, Kouji Kobiyama, Yoshihiro Nishikawa, Masahiro Shiokawa, Norimitsu Uza, Yuzo Kodama, Hiroshi Seno, Ken J. Ishii

GASTROENTEROLOGY, 158(6) S195-S195, May, 2020
体表面積補正Dose intensity(BSA-DI)に着目した肝細胞癌に対するLenvatinib導入の最適化

恵荘裕嗣, 高井淳, 高橋健, 妹尾浩

日本消化器病学会雑誌(Web), 117, 2020
Lenvatinib治療効果解析におけるRelative dose intensity(RDI)の問題点と体表面積補正Dose intensity(BSA-DI)の有用性

恵荘裕嗣, 中野重治, 三嶋眞紗子, 荒澤壮一, 井口恵里子, 中村文保, 竹田治彦, 高井淳, 高橋健, 妹尾浩

日本消化器病学会雑誌(Web), 117, 2020
The role of a quantitative assessment of tumor vascularity using contrast-enhanced ultrasound in molecular targeted therapy for hepatocellular carcinoma

恵荘裕嗣, 中野重治, 荒澤壮一, 井口恵理子, 竹田治彦, 高井淳, 高橋健, 妹尾浩

超音波医学 Supplement, 47, 2020
結節内結節型肝癌の全ゲノムシーケンス解析を用いた新規標的分子同定の試み

竹田治彦, 高井淳, 藤本明洋, 藤本明洋, 恵荘裕嗣, 高橋健, 上田佳秀, 上田佳秀, 田浦康二朗, 上本伸二 …

Pharma Medica, 38(12), 2020
肝予備能評価における線維化マーカーM2BPGiの有用性

恵荘裕嗣, 中野重治, 荒澤壮一, 井口恵理子, 中村文保, 竹田治彦, 高井淳, 高橋健, 妹尾浩

肝臓, 60(Suppl.3) A855-A855, Nov, 2019
造影超音波による腫瘍血流定量評価を用いたLenvatinibの早期治療効果予測

恵荘裕嗣, 中野重治, 荒澤壮一, 井口恵里子, 中村文保, 竹田治彦, 高井淳, 高橋健, 妹尾浩

肝臓, 60(Suppl.3) A952-A952, Nov, 2019
Dose intensityに着目したLenvatinibの治療効果を引き出すための工夫

恵荘裕嗣, 中野重治, 荒澤壮一, 井口恵理子, 中村文保, 竹田治彦, 高井淳, 高橋健, 妹尾浩

肝臓, 60(Suppl.3) A952-A952, Nov, 2019
Intermediate‐stage HCCにおけるTACEから分子標的薬への至適切り替え時期の検討

恵荘裕嗣, 高井淳, 高橋健, 上田佳秀, 妹尾浩

肝臓, 60(Suppl.2) A703-A703, Oct, 2019
新規TLR9アゴニストK3-SPGを用いたがんワクチン免疫療法の消化器がんへの応用(Preclinical cancer vaccine immunotherapy for gastrointestinal cancers using novel nanoparticulate TLR9 agonist K3-SPG)

岡田浩和, 高橋健, 宇座徳光, 児玉裕三, 石井健, 妹尾浩

日本癌学会総会記事, 78回 P-2273, Sep, 2019
腸上皮化生を伴う慢性胃炎粘膜を構成する一腺管あたりの遺伝子異常の解析(Genomic abnormality in single crypts of chronic inflamed gastric mucosa with intestinal metaplasia)

熊谷健, 清水孝洋, 高井淳, 荒澤壮一, 井口恵里子, 竹田治彦, 恵荘裕嗣, 高橋健, 宮本心一, 上田佳秀 …

日本癌学会総会記事, 78回 P-1306, Sep, 2019

Books and Other Publications

PD-1/PD-L1

Jun, 2020
Evolving Immunotherapy Approaches for Hepatocellular Carcinoma. Takahashi K, Marusawa H. Molecular Diagnosis and Targeting for Thoracic and Gastrointestinal Malignancy

Takahashi K, Marusawa H (Role: Joint author)

Springer, Singapore, 2018
Importance of anti-HBs antibody in hepatitis B reactivation

Takahashi Ken (Role: Contributor, Describing main text.)

Nov, 2013
Introduction to foreign laboratory

Takahashi Ken

Jun, 2013
Discoveries concerning new mechanisms for the origin and dissemination of infectious diseases Baruch Samuel Blumberg

Takahashi Ken (Role: Contributor, Describing main text.)

Medical Review, Jun, 2013
Pathogen recognition by Toll-like receptor

Takahashi Ken (Role: Contributor, Describing main text.)

Apr, 2007

Presentations

In situ vaccine immunotherapy for gastrointestinal cancers using novel nanoparticulate TLR9 agonist K3-SPG

Hirokazu Okada, Ken Takahashi, Kouji Kobiyama, Yoshihiro Nishikawa, Masahiro Shiokawa, Norimitsu Uza, Yuzo Kodama, Hiroshi Seno, Ken J Ishii

DDW2020, May 2, 2020
Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection

K.Takahashi, FV.Chisari

16th International Symposium on Hepatitis C Virus and Related Viruses 2009, NICE, France, Oct 4, 2009

Research Projects

Preclinical study of near-infrared photoimmunotherapy for pancreatic cancer that incorporates nanoparticulate TLR9 agonist K3-SPG

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
Preclinical study of in situ vaccine immunotherapy for hepatocellular carcinoma targeting TLR9 and RIG-I

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

TAKAHASHI Ken
Comprehensive analysis of immune response in hapatitis B using novel disease mouse model

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Takahashi Ken
Dissecting themechanism of plasmacytoid dendritic cell activation triggered by hepatitis C virus-infected cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2012

TAKAHASHI Ken

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