2014年1月
Human Plasmacytoid Dendritic Cells Sense Lymphocytic Choriomeningitis Virus-Infected Cells In Vitro
JOURNAL OF VIROLOGY
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- 巻
- 88
- 号
- 1
- 開始ページ
- 752
- 終了ページ
- 757
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1128/JVI.01714-13
- 出版者・発行元
- AMER SOC MICROBIOLOGY
We previously reported that exosomal transfer of hepatitis C virus (HCV) positive-strand RNA from human Huh-7 hepatoma cells to human plasmacytoid dendritic cells (pDCs) triggers pDC alpha/beta interferon (IFN-alpha/beta) production in a Toll-like receptor 7 (TLR7)-dependent, virus-independent manner. Here we show that human pDCs are also activated by a TLR7-dependent, virus-independent, exosomal RNA transfer mechanism by human and mouse hepatoma and nonhepatoma cells that replicate the negative-strand lymphocytic choriomeningitis virus (LCMV).
- リンク情報
- ID情報
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- DOI : 10.1128/JVI.01714-13
- ISSN : 0022-538X
- eISSN : 1098-5514
- Web of Science ID : WOS:000329194600071