2021年4月23日
Pathological structure of visuospatial neglect: A comprehensive multivariate analysis of spatial and non-spatial aspects.
iScience
- ,
- ,
- ,
- ,
- 巻
- 24
- 号
- 4
- 開始ページ
- 102316
- 終了ページ
- 102316
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.isci.2021.102316
- 出版者・発行元
- Elsevier BV
Visuospatial neglect (VSN) is a neurological syndrome of higher brain functions in which an individual fails to detect stimuli on a space that is contralateral to a hemispheric lesion. We performed a comprehensive multivariate analysis based on the principal component analysis (PCA) and cluster analysis in patients with right hemisphere stroke and then performed a determination of different elements of VSN. PCA-based cluster analysis detected distinct aspects of VSN as follows: cluster 1: low arousal and attention state, cluster 2: exogenous neglect, cluster 3: spatial working memory (SWM) deficit. Lesion analysis revealed neural correlates for each cluster and highlighted "disturbance of the ventral attention network" for the stagnation of exogenous attention and "parietal damage" for SWM deficit. Our results reveal a pathological structure of VSN as multiple components of an attention network deficit, and they contribute to the understanding of the mechanisms underlying VSN.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.isci.2021.102316
- ISSN : 2589-0042
- PubMed ID : 33870133
- PubMed Central 記事ID : PMC8042346