論文

国際誌
2021年4月23日

Pathological structure of visuospatial neglect: A comprehensive multivariate analysis of spatial and non-spatial aspects.

iScience
  • Yusaku Takamura
  • ,
  • Shintaro Fujii
  • ,
  • Satoko Ohmatsu
  • ,
  • Shu Morioka
  • ,
  • Noritaka Kawashima

24
4
開始ページ
102316
終了ページ
102316
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.isci.2021.102316
出版者・発行元
Elsevier BV

Visuospatial neglect (VSN) is a neurological syndrome of higher brain functions in which an individual fails to detect stimuli on a space that is contralateral to a hemispheric lesion. We performed a comprehensive multivariate analysis based on the principal component analysis (PCA) and cluster analysis in patients with right hemisphere stroke and then performed a determination of different elements of VSN. PCA-based cluster analysis detected distinct aspects of VSN as follows: cluster 1: low arousal and attention state, cluster 2: exogenous neglect, cluster 3: spatial working memory (SWM) deficit. Lesion analysis revealed neural correlates for each cluster and highlighted "disturbance of the ventral attention network" for the stagnation of exogenous attention and "parietal damage" for SWM deficit. Our results reveal a pathological structure of VSN as multiple components of an attention network deficit, and they contribute to the understanding of the mechanisms underlying VSN.

リンク情報
DOI
https://doi.org/10.1016/j.isci.2021.102316
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33870133
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042346
ID情報
  • DOI : 10.1016/j.isci.2021.102316
  • ISSN : 2589-0042
  • PubMed ID : 33870133
  • PubMed Central 記事ID : PMC8042346

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