論文

査読有り
2019年2月

Epileptic Seizure Suppression by Focal Brain Cooling with Recirculating Coolant Cooling System: Modeling and Simulation

IEEE Transactions on Neural Systems and Rehabilitation Engineering
  • Kei Hata
  • ,
  • Koichi Fujiwara
  • ,
  • Takao Inoue
  • ,
  • Takuto Abe
  • ,
  • Takatomi Kubo
  • ,
  • Toshitaka Yamakawa
  • ,
  • Sadahiro Nomura
  • ,
  • Hirochika Imoto
  • ,
  • Michiyasu Suzuki
  • ,
  • Manabu Kano

27
2
開始ページ
162
終了ページ
171
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1109/TNSRE.2019.2891090

© 2001-2011 IEEE. A focal brain cooling system for treatment of refractory epilepsy that is implantable and wearable may permit patients with this condition to lead normal daily lives. We have developed such a system for cooling of the epileptic focus by delivery of cold saline to a cooling device that is implanted cranially. The outflow is pumped for circulation and cooled by a Peltier device. Here, we describe the design of the system and evaluate its feasibility by simulation. Mathematical models were constructed based on equations of fluid dynamics and data from a cat model. Computational fluid dynamics simulations gave the following results: 1) a cooling device with a complex channel structure gives a more uniform temperature in the brain; 2) a cooling period of <10 min is required to reach an average temperature of 25.0°Cat 2 mm below the brain surface, which is the target temperature for seizure suppression. This time is short enough for cooling of the brain before seizure onset after seizure prediction by an intracranial electroencephalogram-based algorithm; and 3) battery charging would be required once every several days for most patients. These results suggest that the focal brain cooling system may be clinically applicable.

リンク情報
DOI
https://doi.org/10.1109/TNSRE.2019.2891090
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30624219
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85061592594&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85061592594&origin=inward
ID情報
  • DOI : 10.1109/TNSRE.2019.2891090
  • ISSN : 1534-4320
  • PubMed ID : 30624219
  • SCOPUS ID : 85061592594

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