論文

査読有り
2017年9月

Epidural focal brain cooling abolishes neocortical seizures in cats and non-human primates

NEUROSCIENCE RESEARCH
  • Takao Inoue
  • Masami Fujii
  • Hiroyuki Kida
  • Toshitaka Yamakawa
  • Yuichi Maruta
  • Tatsuji Tokiwa
  • Yeting He
  • Sadahiro Nomura
  • Yuji Owada
  • Takeshi Yamakawa
  • Michiyasu Suzuki
  • 全て表示

122
開始ページ
35
終了ページ
44
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neures.2017.04.007
出版者・発行元
ELSEVIER IRELAND LTD

Focal brain cooling (FBC) is under investigation in preclinical trials of intractable epilepsy (IE), including status epilepticus (SE). This method has been studied in rodents as a possible treatment for epileptic disorders, but more evidence from large animal studies is required. To provide evidence that FBC is a safe and effective therapy for IE, we investigated if FBC using a titanium cooling plate can reduce or terminate focal neocortical seizures without having a significant impact on brain tissue. Two cats and two macaque monkeys were chronically implanted with an epidural FBC device over the somatosensory and motor cortex. Penicillin G was delivered via the intracranial cannula for induction of local seizures. Repetitive FBC was performed using a cooling device implanted for a medium-term period (FBC for 30 min at least twice every week; 3 months total) in three of the four animals. The animals exhibited seizures with repetitive epileptiform discharges (EDs) after administration of penicillin G, and these discharges decreased at less than 20 degrees C cooling with no adverse histological effects. The results of this study suggest that epidural FBC is a safe and effective potential treatment for IE and SE. (C) 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.neures.2017.04.007
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28450153
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000413123100005&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.neures.2017.04.007
  • ISSN : 0168-0102
  • eISSN : 1872-8111
  • PubMed ID : 28450153
  • Web of Science ID : WOS:000413123100005

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