2010年8月
Loss of Trx-2 enhances oxidative stress-dependent phenotypes in Drosophila
FEBS LETTERS
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- 巻
- 584
- 号
- 15
- 開始ページ
- 3398
- 終了ページ
- 3401
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.febslet.2010.06.034
- 出版者・発行元
- ELSEVIER SCIENCE BV
Overexpression of thioredoxin (TRX)confers oxidative stress resistance and extends lifespan in mammals and insects. However, less is known about phenotypes associated with loss of TRX. We investigated loss-of-function phenotypes of Trx-2 in Drosophila, and found that the mutant flies are hyper-susceptible to paraquat, a free radical generator, but not to hydrogen peroxide. They contain a high amount of protein carbonyl, which dramatically increases with age. Trx-2 mutants express high levels of anti-oxidant genes, such as superoxide dismutase, catalase, and glutathione synthetase. This is the first demonstration of biochemical and physiological consequences caused by loss of Trx-2 in Drosophila. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.febslet.2010.06.034
- ISSN : 0014-5793
- ORCIDのPut Code : 36621314
- Web of Science ID : WOS:000281033600026