Takashi Nagata

Profile Information

Affiliation: The Institute for Solid State Physics, The University of Tokyo

Degree: 博士（理学）(大阪市立大学)

J-GLOBAL ID: 201801007146727878
researchmap Member ID: B000300017

Research Areas

Committee Memberships

Jan, 2023 - Present

分野別専門委員, 日本生物物理学会
2019 - Present

評議員, 日本比較生理生化学会

Awards

Papers

Light intensity-dependent arrestin switching for inactivation of a light-sensitive GPCR, bistable opsin.

Baoguo Shen, Seiji Wada, Tomohiro Sugihara, Takashi Nagata, Haruka Nishioka, Emi Kawano-Yamashita, Takeaki Ozawa, Mitsumasa Koyanagi, Akihisa Terakita

iScience, 28(2) 111706-111706, Feb 21, 2025
Active state structures of a bistable visual opsin bound to G proteins

Oliver Tejero, Filip Pamula, Mitsumasa Koyanagi, Takashi Nagata, Pavel Afanasyev, Ishita Das, Xavier Deupi, Mordechai Sheves, Akihisa Terakita, Gebhard F. X. Schertler …

Nature Communications, Oct 16, 2024 Peer-reviewed
HulaCCR1, a pump-like cation channelrhodopsin discovered in a lake microbiome

Shunki Takaramoto, Shai Fainsod, Takashi Nagata, Andrey Rozenberg, Oded Béjà, Keiichi Inoue

Journal of Molecular Biology, 168844-168844, Oct, 2024 Peer-reviewed
Hydrogen-Bonding and Hydrophobic Interaction Networks as Structural Determinants of Microbial Rhodopsin Function

Éva Bertalan, Masae Konno, María del Carmen Marín, Reza Bagherzadeh, Takashi Nagata, Leonid Brown, Keiichi Inoue, Ana-Nicoleta Bondar

The Journal of Physical Chemistry B, Jul 18, 2024 Peer-reviewed
Functional characterization of four opsins and two G alpha subtypes co-expressed in the molluscan rhabdomeric photoreceptor

Ryota Matsuo, Mitsumasa Koyanagi, Tomohiro Sugihara, Taishi Shirata, Takashi Nagata, Keiichi Inoue, Yuko Matsuo, Akihisa Terakita

BMC Biology, 21(1), Dec 18, 2023 Peer-reviewed
Multiple roles of a conserved glutamate residue for unique biophysical properties in a new group of microbial rhodopsins homologous to TAT rhodopsin

Kentaro Mannen, Takashi Nagata, Andrey Rozenberg, Masae Konno, María del Carmen Marín, Reza Bagherzadeh, Oded Béjà, Takayuki Uchihashi, Keiichi Inoue

Journal of Molecular Biology, 168331-168331, Oct, 2023 Peer-reviewed
Structural basis for ion selectivity in potassium-selective channelrhodopsins.

Seiya Tajima, Yoon Seok Kim, Masahiro Fukuda, YoungJu Jo, Peter Y Wang, Joseph M Paggi, Masatoshi Inoue, Eamon F X Byrne, Koichiro E Kishi, Seiwa Nakamura …

Cell, Aug 24, 2023 Peer-reviewed
Difference FTIR Spectroscopy of Jumping Spider Rhodopsin-1 at 77 K.

Shunpei Hanai, Takashi Nagata, Kota Katayama, Shino Inukai, Mitsumasa Koyanagi, Keiichi Inoue, Akihisa Terakita, Hideki Kandori

Biochemistry, 62(8) 1347-1359, Apr 18, 2023 Peer-reviewed
Reversible Photoreaction of a Retinal Photoisomerase, Retinal G-Protein-Coupled Receptor RGR

Naoya Morimoto, Takashi Nagata, Keiichi Inoue

Biochemistry, 62(9) 1429-1432, Apr 14, 2023 Peer-reviewedLead author
Phototrophy by antenna-containing rhodopsin pumps in aquatic environments.

Ariel Chazan, Ishita Das, Takayoshi Fujiwara, Shunya Murakoshi, Andrey Rozenberg, Ana Molina-Márquez, Fumiya K Sano, Tatsuki Tanaka, Patricia Gómez-Villegas, Shirley Larom …

Nature, 615(7952) 535-540, Mar 1, 2023 Peer-reviewed
High-performance optical control of GPCR signaling by bistable animal opsins MosOpn3 and LamPP in a molecular property–dependent manner

Mitsumasa Koyanagi, Baoguo Shen, Takashi Nagata, Lanfang Sun, Seiji Wada, Satomi Kamimura, Eriko Kage-Nakadai, Akihisa Terakita

Proceedings of the National Academy of Sciences, 119(48) e2204341119, Nov 29, 2022 Peer-reviewed
Expression of a homologue of a vertebrate non-visual opsin Opn3 in the insect photoreceptors

Mitsumasa Koyanagi, Hayato Honda, Hirohisa Yokono, Ryu Sato, Takashi Nagata, Akihisa Terakita

Philosophical Transactions of the Royal Society B: Biological Sciences, 377(1862) 20210274-20210274, Sep 5, 2022
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels

Andrey Rozenberg, Igor Kaczmarczyk, Donna Matzov, Johannes Vierock, Takashi Nagata, Masahiro Sugiura, Kota Katayama, Yuma Kawasaki, Masae Konno, Yujiro Nagasaka …

Nature Structural & Molecular Biology, 29(6) 592-603, Jun, 2022
Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine

Koichiro E. Kishi, Yoon Seok Kim, Masahiro Fukuda, Masatoshi Inoue, Tsukasa Kusakizako, Peter Y. Wang, Charu Ramakrishnan, Eamon F.X. Byrne, Elina Thadhani, Joseph M. Paggi …

Cell, 185(4) 672-689.e23, Feb, 2022
Energy transfer in ubiquitous rhodopsin pumps with xanthophyll antennas

Chazan, Ariel, Das, Ishita, Fujiwara, Takayoshi, Murakoshi, Shunya, Shihoya, Wataru, Rozenberg, Andrey, Molina-M{\'a}rquez, Ana, Larom, Shirley, Pushkarev, Alina, Malakar, Partha …

bioRxiv, 2022
Diverse heliorhodopsins detected via functional metagenomics in freshwater Actinobacteria, Chloroflexi and Archaea

Ariel Chazan, Andrey Rozenberg, Kentaro Mannen, Takashi Nagata, Ran Tahan, Shir Yaish, Shirley Larom, Keiichi Inoue, Oded B{\'{e } }j{\`{a } }, Alina Pushkarev

Environmental Microbiology, 24(1) 110-121, Jan, 2022 Peer-reviewed
Author Correction: Exploration of natural red-shifted rhodopsins using a machine learning-based Bayesian experimental design (Communications Biology, (2021), 4, 1, (362), 10.1038/s42003-021-01878-9)

Keiichi Inoue, Masayuki Karasuyama, Ryoko Nakamura, Masae Konno, Daichi Yamada, Kentaro Mannen, Takashi Nagata, Yu Inatsu, Hiromu Yawo, Kei Yura …

Communications Biology, 4(1), Dec 1, 2021
Rhodopsins at a glance

Takashi Nagata, Keiichi Inoue

Journal of Cell Science, 134(22), Nov 15, 2021
Exploration of natural red-shifted rhodopsins using a machine learning-based Bayesian experimental design

Keiichi Inoue, Masayuki Karasuyama, Ryoko Nakamura, Masae Konno, Daichi Yamada, Kentaro Mannen, Takashi Nagata, Yu Inatsu, Hiromu Yawo, Kei Yura …

Communications Biology, 4(1) 362-362, Mar, 2021 Peer-reviewed
Functional identification of an opsin kinase underlying inactivation of the pineal bistable opsin parapinopsin in zebrafish

Baoguo Shen, Seiji Wada, Haruka Nishioka, Takashi Nagata, Emi Kawano-Yamashita, Mitsumasa Koyanagi, Akihisa Terakita

Zoological Letters, 7(1) 1-1, Feb 12, 2021 Peer-reviewed

Misc.

Unique characteristics in chromophore photoisomerization of the novel rhodopsin, bestrhodopsin

永田崇, 川崎佑真, 今野雅恵, 今野雅恵, 長坂勇次郎, 青山真子, 片山耕大, 片山耕大, ROZENBERG Andrey, KACZMARCZYK Igor …

日本化学会春季年会講演予稿集(Web), 103rd, 2023
Expanding horizons of biosciences by light-control

Mikio Kataoka, Takashi Nagata

Biophysics and Physicobiology, 18 13-15, Feb, 2021 Peer-reviewedCorresponding author
アスガルドアーキア由来の新奇光駆動型内向きプロトンポンプ:シゾロドプシンの機能・分光・構造研究

井上圭一, 志甫谷渉, 今野雅恵, 今野雅恵, 樋口晶光, 但馬聖也, 古谷祐詞, 古谷祐詞, 川崎佑真, 永田崇 …

生体分子科学討論会講演要旨集, 47th, 2021
Spectroscopic and structural studies of the H⁺ transport mechanism of light-driven inward H⁺-pumping rhodopsin, schizorhodopsin

井上圭一, 志甫谷渉, 今野雅恵, 今野雅恵, 樋口晶光, 但馬聖也, 古谷祐詞, 川崎佑真, 永田崇, 永田崇 …

日本生体エネルギー研究会討論会講演要旨集, 46th, 2020
Image Defocus Is a Cue for Depth Perception in a Jumping Spider

Takashi NAGATA, Kentaro ARIKAWA, Akihisa TERAKITA

Seibutsu Butsuri, 53(2) 109-110, 2013 Peer-reviewed
ピンぼけ像を利用したハエトリグモの奥行きの知覚

永田崇, 小柳光正, 寺北明久

新着論文レビュー, 2012
Molecular Evolution and Functional Diversity of Opsin-Based Photopigments

T. Nagata, M. Koyanagi, A. Terakita

Photobiological Sciences Online, 2010 Peer-reviewedInvited
Identification and characterization of a visual pigment expressed in posterior median eyes of jumping spiders

Takashi Nagata, Mitsumasa Koyanagi, Kunio Isono, Shigeki Yama-shita, Fumio Tokunaga, Kentaro Arikawa, Akihisa Terakita

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 151(4) 449-449, Dec, 2008
A relationship between visual pigments and color vision in jumping spiders

Takashi Nagata, Mitsumasa Koyanagi, Shigeki Yamashita, Fumio Tokunaga, Akihisa Terakita

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 148(3) 344-345, Nov, 2007
Expression analyses of visual pigments in the four-layered retina of jumping spider

Takashi Nagata, Mitsumasa Koyanagi, Shigeki Yamashita, Fumio Tokunaga

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 145(3-4) 408-408, Nov, 2006
Identification and characterization of visual pigments of the jumping spider

Takashi Nagata, Mitsumasa Koyanagi, Shigeki Yamashita, Fumio Tokunaga

ZOOLOGICAL SCIENCE, 22(12) 1478-1478, Dec, 2005

Books and Other Publications

Optogenetics : Light-Sensing Proteins and Their Applications in Neuroscience and Beyond

(Role: Joint author, 141-151)

Springer Singapore, 2021
光と生命の事典

日本光生物学協会光と生命の事典編集委員会, 日本光生物学協会 (Role: Joint author)

朝倉書店, Feb, 2016 (ISBN: 9784254171617)
Optogenetics : light-sensing proteins and their applications

八尾, 寛, 神取, 秀樹, 小泉, 周 (Role: Joint author, 77-88)

Springer, 2015 (ISBN: 9784431555155)
研究者が教える動物飼育第2巻―昆虫とクモの仲間―

(Role: Joint author)

共立出版, May, 2012 (ISBN: 9784320057197)

Presentations

新奇チャネルロドプシンの磁場効果探索における可能性

学術変革領域研究（A) 「1000テスラ科学」領域・第４回領域会議, Dec 7, 2024
レチナール光異性化酵素ロドプシンの吸収波長特性と可逆的光反応

森本直也, 永田崇, 井上圭一

日本化学会第104春季年会, Mar 20, 2024
光受容タンパク質の光反応過程における磁場効果の探索

永田崇

学術変革領域研究（A) 「1000テスラ科学」領域・第2回領域会議, Dec 5, 2023 Invited
機械学習に基づく動物ロドプシンの吸収波長予測に向けて

永田崇

JST CREST バイオDX 「データ駆動型サイエンスによる中分子細胞膜透過性の創造」R5年度『信州伊那合宿ゼミ』, Sep 20, 2023
脊椎動物が持つレチナール光異性化酵素ロドプシンRGRの吸収・光反応特性

森本直也, 永田崇, 井上圭一

日本動物学会第94回大会, Sep 8, 2023
光受容タンパク質ロドプシンの光反応と磁場効果の可能性

永田崇

学術変革領域研究（A) 「1000テスラ科学」領域・第1回領域会議, Jun 20, 2023 Invited
新奇光受容タンパク質ベストロドプシンの特異な発色団光異性化反応

永田崇, 川﨑佑真, 今野雅恵, 長坂勇次郎, 青山真子, 片山耕大, Andrey Rozenberg, Igor Kaczmarczyk, Donna Matzov, Moran Shalev-Benami, Oded Béjà, 神取秀樹, 井上圭一

日本化学会第103春季年会, Mar 24, 2023
Development of a dark-active, light-inactivated optogenetic tool for controlling G protein signaling toward vision restoration

Takashi Nagata

19th International Conference on Retinal Proteins, Nov 1, 2022 Invited
クモのロドプシン類の分子生理学的研究に基づく動物の光受容の多様性

永田崇

第22回日本光生物学協会年会, Aug 10, 2022 Invited
レチナール光異性化酵素ロドプシンRGRの光吸収・反応特性の解析

森本直也, 永田崇, 井上圭一

第11回日本生物物理学会関東支部会, Mar 3, 2022
Molecular physiological study on rhodopsin-based visual and non-visual photoreceptions of a jumping spider

永田崇

日本比較生理生化学会第43回札幌大会, Dec 5, 2021 Invited
視覚再生に向けた暗活性・光不活性化GPCR型光遺伝学ツールの開発

永田崇

第59回生物物理学会年会, Nov 26, 2021 Invited
A novel type of opsin with optogenetic potential: Animal opsin-based photopigment

Takashi Nagata

10th OCARINA International Symposium, Mar 5, 2019
Dark-active and light-inactivated G protein-coupled receptors based on an animal opsin, peropsin

Takashi Nagata, Mitsumasa Koyanagi, Robert Lucas, Akihisa Terakita

Sep 15, 2018 Invited
Peropsin as a potential light-inactivated G protein-coupled receptor

18th International Conference on Retinal Proteins, Sep, 2018
松果体波長識別応答に関わる光受容タンパク質パラピノプシンのアレスチン結合に関する解析

永田崇, 小柳光正, 山下(川野)絵美, 和田清二, 小澤岳昌, 寺北明久

日本動物学会第８８回富山大会, Sep 21, 2017
ハエトリグモの第一次視覚中枢における主眼視細胞の投射様式

永田崇, 木下充代, 蟻川謙太郎, 小柳光正, 寺北明久

日本動物学会第85回大会, Sep 11, 2014
Depth perception from defocus of retinal images received by a three-dimensionally distributed visual pigment in a jumping spider eye

Takashi Nagata

11th International Congress of Neuroethology, Jul 30, 2014 Invited
ハエトリグモの奥行き知覚における視物質の吸収特性の寄与

永田崇

第５１回日本生物物理学会年会, Oct 28, 2013
ハエトリグモの4層構造網膜に存在する視細胞の投射パターンの解析

永田崇, 木下充代, 蟻川謙太郎, 小柳光正, 寺北明久

日本動物学会第８４回大会, Sep 28, 2013

Professional Memberships

Feb, 2023 - Present

日本蛋白質科学会
Nov, 2022 - Present

日本化学会
The Japanese Society for Comparative Physiology and Biochemistry
THE ZOOLOGICAL SOCIETY OF JAPAN
THE BIOPHYSICAL SOCIETY OF JAPAN

Research Projects

1000 T化学反応の探索と解明

科学研究費助成事業, 学術変革領域研究(A), 日本学術振興会, Apr, 2023 - Mar, 2028

木村尚次郎, 若狭雅信, 草本哲郎, 永田崇, 北川裕一, 宮島大吾
脳深部への光伝達の新たな経路の解析

科学研究費助成事業挑戦的研究(萌芽), 挑戦的研究(萌芽), 日本学術振興会, Jul, 2020 - Mar, 2023

永田崇
光OFF型オプシンによる高感度かつ自然な視覚再生

個人型研究(さきがけ), 科学技術振興機構(JST), Oct, 2018 - Mar, 2021

永田崇
クモの単眼における「ピンぼけ視覚」の生理学的・行動学的解析

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2011 - 2013

永田崇
視物質解析に基づいた動物界第三の色覚系としてのクモ類色覚メカニズムの解明

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2007 - 2009

永田崇

Profile Information

Research Areas

Committee Memberships

Awards

Papers

Misc.

Books and Other Publications

Presentations

Professional Memberships

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