論文

2013年10月

Case Report: An unusual observation of elastophagocytosis in a patient with cutaneous CD5(+) diffuse large B cell lymphoma.

BIOMEDICAL RESEARCH-INDIA
  • Yuji Ohtsuki
  • ,
  • Yuki Matsuka
  • ,
  • Wakana Tanihata
  • ,
  • Masako Izumimoto
  • ,
  • Yuhei Okada
  • ,
  • Gang-Hong Lee
  • ,
  • Mutsuo Furihata
  • ,
  • Katsuyoshi Takata
  • ,
  • Tadashi Yoshino

24
4
開始ページ
521
終了ページ
524
記述言語
英語
掲載種別
研究論文(学術雑誌)
出版者・発行元
SCIENTIFIC PUBLISHERS INDIA

A Japanese man in his mid-60s reported having a subcutaneous mass for a period of 8 months, after which it gradually enlarged in size and was surgically extirpated. The resected tumor was 10 x 8 mm in size, and the cut surface was smooth, solid, and whitish. Histological analysis revealed the presence of medium to large lymphoid cells that had proliferated to form a solid mass. The diffuse proliferating cells stained positive for CD20, CD79a, and CD5, but were negative for CD3, CD30, and CD10, and the MIB-1 index was very high. On the basis of these findings, the tumor was diagnosed as cutaneous CD5(+) diffuse large B cell lymphoma. Interestingly, detailed analysis revealed elastophagocytosis, with scattered, fragmented elastic fibers engulfed by macrophages that were intermixed with tumor cells. These macrophages were mostly multinucleated giant cells, apparently forming part of a foreign body-type reaction. Elastic fiber staining clearly revealed positively stained fragmented fibers in the cytoplasm of the macrophages, which were densely positive for CD68, in sharp contrast to the CD68-negative tumor cells. The final diagnosis was cutaneous CD5(+) diffuse large B cell lymphoma exhibiting unusual elastophagocytosis. The patient's clinical course was good, and the tumor disappeared completely after 3 cycles of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy with radiation.

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000325694600019&DestApp=WOS_CPL
ID情報
  • ISSN : 0970-938X
  • eISSN : 0976-1683
  • Web of Science ID : WOS:000325694600019

エクスポート
BibTeX RIS