論文

2018年1月12日

Hippocampal activity during serotonergic neuronal activity manipulation using optogenetics

2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Proceedings
  • Kondo D
  • ,
  • Mitsukura Y
  • ,
  • Yoshida K
  • ,
  • Tsutsui-Kimura I
  • ,
  • Takata N
  • ,
  • Tanaka K

2018-January
開始ページ
1
終了ページ
6
DOI
10.1109/SPMB.2017.8257057
出版者・発行元
2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Proceedings

© 2017 IEEE. In order to improve brain dysfunction such as mental disease, it is necessary to clarify the mechanism of activity in the brain. To clarify the relationship between the brain region and the neurotransmitter is important for elucidating the brain. Especially investigating the relationship between serotonin and hippocampus leads to elucidate of the mechanism of depression and sleep. The technique called optogenetics enabled only specific cells to be manipulated by light stimulation in recent years. This technique is a useful technique for clarifying the function of the brain. Because instead of stimulating multiple cells such as electrical stimulation, optogenetics can stimulate only specific cells, so that its function can be clarified. This study focused on neurotransmitter serotonin and the brain region called the hippocampus. For these purpose we can clarify the relationship between serotonin and hippocampus by manipulating serotonin neural activity using optogenetics while invasively measuring the ventral hippocampus of the mouse. In addition, identification of pyramidal cell layer is necessary to clarify hippocampal activity. Currently, visual estimation is perfor

リンク情報
DOI
https://doi.org/10.1109/SPMB.2017.8257057
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85050521742&origin=inward
ID情報
  • DOI : 10.1109/SPMB.2017.8257057

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