論文

査読有り
2013年10月

Effect of chitosan-gluconic acid conjugate/poly(vinyl alcohol) cryogels as wound dressing on partial-thickness wounds in diabetic rats

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
  • Takayuki Takei
  • ,
  • Hideki Nakahara
  • ,
  • Sadao Tanaka
  • ,
  • Hiroto Nishimata
  • ,
  • Masahiro Yoshida
  • ,
  • Koei Kawakami

24
10
開始ページ
2479
終了ページ
2487
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s10856-013-4991-5
出版者・発行元
SPRINGER

We previously developed chitosan cryogels from chitosan-gluconic acid conjugate without using toxic additives for wound care. In this study, we improved physiological characteristics of the previous cryogels by incorporating poly(vinyl alcohol) that also form cryogels. Mechanical strength of the cryogels was more than two times higher than that of the previous cryogels. Furthermore, the incorporation of poly(vinyl alcohol) enhanced water retention and resistance to degradation of the gels by lysozyme. The cryogels retained the favorable biological properties of the previous cryogels that they accelerate infiltration of inflammatory cells into wound sites. Time period for repairing 50 % of initial area of partial-thickness skin wound treated with the cryogels (4.0 +/- A 1.1 days) was shorter than those with gauze (6.5 +/- A 0.3 days) or a commercial hydrogel dressing (5.7 +/- A 0.3 days). Finally, we confirmed that incorporation of basic fibroblast growth factor into the cryogels was effective to further accelerate wound healing (2.7 +/- A 1.0 days). These results demonstrate that the cryogels in this study are promising for wound care.

Web of Science ® 被引用回数 : 11

リンク情報
DOI
https://doi.org/10.1007/s10856-013-4991-5
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23801501
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000324672900017&DestApp=WOS_CPL