論文

査読有り
2013年8月

Injectable and biodegradable sugar beet pectin/gelatin hydrogels for biomedical applications

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
  • Takayuki Takei
  • ,
  • Kotaro Sugihara
  • ,
  • Masahiro Yoshida
  • ,
  • Koei Kawakami

24
11
開始ページ
1333
終了ページ
1342
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1080/09205063.2012.757727
出版者・発行元
TAYLOR & FRANCIS LTD

Injectable hydrogels have advantages over pre-formed hydrogels in biomedical applications. In our previous study, we showed usefulness of sugar beet pectin (SBP) as an injectable gel material. However, the in vivo biodegradability of the gels was low because animals lack suitable hydrolytic enzymes of SBP. In this study we developed SBP-based injectable gels with higher in vivo biodegradability than the previous SBP gels by incorporating biodegradable gelatin into the latter. An aqueous solution with dissolved SBP and gelatin rapidly (< 1 min) formed gels through a horseradish peroxidase-catalyzed oxidative coupling reaction between feruloyl moieties on the SBP molecules and phenolic moieties on the gelatin molecules. Gelation time and mechanical properties of the gels were tunable by adjusting the polymer concentrations. The gels containing doxorubicin, an anti-cancer drug, successfully suppressed the growth of a solid tumor created by subcutaneous injection of mouse melanoma B16F1 cells into nude mice. These results indicate that injectable and biodegradable SBP/gelatin gels are useful in biomedical applications.

Web of Science ® 被引用回数 : 17

リンク情報
DOI
https://doi.org/10.1080/09205063.2012.757727
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23796034
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000320753600004&DestApp=WOS_CPL