Katsuya Takenaka

Profile Information

Affiliation: Manager, Basic Research Unit, Administration Department, TR Company, Shin Nippon Biomedical Laboratories, Ltd.
: Kanagawa Cancer Center, Research Institute

Degree: 博士（理学）(京都大学)
修士（理学）(東京大学)
学士（理学）(東京大学)

Researcher number: 20378706
J-GLOBAL ID: 201801016346722578
researchmap Member ID: B000348025

Research Interests

hypoxia

Research Areas

Research History

Apr, 2021 - Present

Manager, Basic Research Unit, Administration Department, TR Company, Shin Nippon Biomedical Laboratories, Ltd.
Oct, 2020 - Present

Kanagawa Cancer Center, Research Institute
Mar, 2020 - Mar, 2021

Manager, Basic Research Planning Unit, Administration Department, TR Company, Shin Nippon Biomedical Laboratories, Ltd.
Apr, 2015 - Mar, 2020

Kanagawa Cancer Center, Research Institute
Apr, 2015 - Mar, 2016

Medical Research Institute, Tokyo Medical and Dental University
Apr, 2006 - Mar, 2015

Medical Research Institute, Tokyo Medical and Dental University
Dec, 2003 - Mar, 2006

Graduate School of Medicine, Kyoto University
Apr, 2002 - Nov, 2003

Graduate School of Medicine, Kyoto University
Apr, 2001 - Mar, 2002

マックスプランク財団奨学生, マックスプランク生化学研究所細胞生物学教室
Oct, 1999 - Mar, 2001

日本学術振興会海外特別研究員, マックスプランク生化学研究所細胞生物学教室
Apr, 1999 - Sep, 1999

日本学術振興会海外特別研究員, ジュネーブ大学理学部分子生物学科
Apr, 1997 - Mar, 1999

Graduate School of Science, Kyoto University
Apr, 1994 - Mar, 1997

Institute for Virus Research, Kyoto University

Education

Apr, 1994 - Mar, 1997

生物物理学専攻, 理学研究科, 京都大学大学院
Apr, 1992 - Mar, 1994

生物化学専攻, 理学系研究科, 東京大学大学院
Apr, 1988 - Mar, 1992

The University of Tokyo

Committee Memberships

2010 - 2010

企画委員, International Conference on Radiation and Cancer Biology in Nagasaki 2010
2004 - 2004

一般演題編成委員, 第27回日本分子生物学会年会

Papers

Cancer cell-derived CD69 induced under lipid and oxygen starvation promotes ovarian cancer progression via fibronectin.

Shiro Koizume, Tomohiko Kanayama, Yayoi Kimura, Hisashi Hirano, Tomoko Takahashi, Yukihide Ota, Kaoru Miyazaki, Mitsuyo Yoshihara, Yoshiyasu Nakamura, Tomoyuki Yokose …

Cancer science, Feb 28, 2023
Cholesterol Starvation and Hypoxia Activate the FVII Gene via the SREBP1-GILZ Pathway in Ovarian Cancer Cells to Produce Procoagulant Microvesicles

Shiro Koizume, Tomoko Takahashi, Mitsuyo Yoshihara, Yoshiyasu Nakamura, Wolfram Ruf, Katsuya Takenaka, Etsuko Miyagi, Yohei Miyagi

Thrombosis and Haemostasis, 119(7) 1058-1071, 2019 Peer-reviewed
BRCA2 Phosphorylated by PLK1 Moves to the Midbody to Regulate Cytokinesis Mediated by Nonmuscle Myosin IIC

Miho Takaoka, Hiroko Saito, Katsuya Takenaka, Yoshio Miki, Akira Nakanishi

CANCER RESEARCH, 74(5) 1518-1528, Mar, 2014 Peer-reviewed
Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair

Yuka Nakazawa, Kensaku Sasaki, Norisato Mitsutake, Michiko Matsuse, Mayuko Shimada, Tiziana Nardo, Yoshito Takahashi, Kaname Ohyama, Kosei Ito, Hiroyuki Mishima …

NATURE GENETICS, 44(5) 586-+, May, 2012 Peer-reviewed
BRCA2 and Nucleophosmin Coregulate Centrosome Amplification and Form a Complex with the Rho Effector Kinase ROCK2

Hui-Feng Wang, Katsuya Takenaka, Akira Nakanishi, Yoshio Miki

CANCER RESEARCH, 71(1) 68-77, Jan, 2011 Peer-reviewed
PTIP promotes DNA double-strand break repair through homologous recombination

Xin Wang, Katsuya Takenaka, Shunichi Takeda

GENES TO CELLS, 15(3) 243-254, Mar, 2010 Peer-reviewed
Three DNA Polymerases, Recruited by Different Mechanisms, Carry Out NER Repair Synthesis in Human Cells

Tomoo Ogi, Siripan Limsirichaikul, Rene M. Overmeer, Marcel Volker, Katsuya Takenaka, Ross Cloney, Yuka Nakazawa, Atsuko Niimi, Yoshio Miki, Nicolaas G. Jaspers …

MOLECULAR CELL, 37(5) 714-727, Mar, 2010 Peer-reviewed
Introduction and characterization of a polymerase-dead point mutation into the POLK gene in vertebrates

Katsuya Takenaka, Yoshio Miki

FEBS LETTERS, 583(4) 661-664, Feb, 2009 Peer-reviewedLead author
Genetic Evidence for Single-Strand Lesions Initiating Nbs1-Dependent Homologous Recombination in Diversification of Ig V in Chicken B Lymphocytes

Makoto Nakahara, Eiichiro Sonoda, Kuniharu Nojima, Julian E. Sale, Katsuya Takenaka, Koji Kikuchi, Yoshihito Taniguchi, Kyoko Nakamura, Yoshiki Sumitomo, Ronan T. Bree …

PLOS GENETICS, 5(1), Jan, 2009 Peer-reviewed
Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig V in chicken B lymphocytes

Makoto Nakahara, Eiichiro Sonoda, Kuniharu Nojima, Julian E. Sale, Katsuya Takenaka, Koji Kikuchi, Yoshihito Taniguchi, Kyoko Nakamura, Yoshiki Sumitomo, Ronan T. Bree …

PLoS Genetics, 5(1), Jan, 2009 Peer-reviewed
Novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage

Go Tomiyoshi, Akira Nakanishi, Katsuya Takenaka, Kiyotsugu Yoshida, Yoshio Miki

CANCER SCIENCE, 99(4) 747-754, Apr, 2008 Peer-reviewed
Reconstitution of Golgi disassembly by mitotic Xenopus egg extract in semi-intact MDCK cells.

Fumi Kano, Katsuya Takenaka, Masayuki Murata

Methods in molecular biology (Clifton, N.J.), 322 357-365, Jul 4, 2006 Peer-reviewed
Critical roles for polymerase zeta in cellular tolerance to nitric oxide-induced DNA damage

XH Wu, K Takenaka, E Sonoda, H Hochegger, S Kawanishi, T Kawamoto, S Takeda, M Yamazoe

CANCER RESEARCH, 66(2) 748-754, Jan, 2006 Peer-reviewed
Involvement of vertebrate Pol kappa in translesion DNA synthesis across DNA monoalkylation damage

K Takenaka, T Ogi, T Okada, E Sonoda, CX Guo, EC Friedberg, S Takeda

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(4) 2000-2004, Jan, 2006 Peer-reviewedLead author
MEK and Cdc2 kinase are sequentially required for Golgi disassembly in MDCK cells by the mitotic Xenopus extracts

F Kano, K Takenaka, A Yamamoto, K Nagayama, E Nishida, M Murata

JOURNAL OF CELL BIOLOGY, 149(2) 357-368, Apr, 2000 Peer-reviewed
Activation of p38 in the spindle assembly checkpoint.

竹中克也, 西田栄介

実験医学, 16(17) 2217-2219, Nov, 1998 Peer-reviewedInvitedLead author
Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest

K Takenaka, T Moriguchi, E Nishida

SCIENCE, 280(5363) 599-602, Apr, 1998 Peer-reviewedLead author
MAP kinase is required for the spindle assembly checkpoint but is dispensable for the normal M phase entry and exit in Xenopus egg cell cycle extracts

K Takenaka, Y Gotoh, E Nishida

JOURNAL OF CELL BIOLOGY, 136(5) 1091-1097, Mar, 1997 Peer-reviewedLead author
Functions of MAP Kinase in Cell Cycle Regulation.

竹中克也, 後藤由季子, 西田栄介

蛋白質核酸酵素, 41(12) 1658-1665, Sep 1, 1996 Peer-reviewedInvitedLead author
CHARACTERIZATION OF RECOMBINANT XENOPUS MAP KINASE KINASES MUTATED AT POTENTIAL PHOSPHORYLATION SITES

Y GOTOH, S MATSUDA, K TAKENAKA, S HATTORI, A IWAMATSU, M ISHIKAWA, H KOSAKO, E NISHIDA

ONCOGENE, 9(7) 1891-1898, Jul, 1994 Peer-reviewed

Misc.

転写因子HIF1とSREBP1による共同的GILZ発現増強は卵巣がん細胞の凝固性細胞外小胞生成に重要である(HIF1 and SREBP1 collaborate to induce GILZ expression to produce procoagulant microvesicles in ovarian cancer cells)

小井詰史朗, 中村圭靖, 吉原光代, 宮城悦子, 竹中克也, 宮城洋平

日本癌学会総会記事, 78回 E-1016, Sep, 2019
血清飢餓低酸素環境で発現誘導される酵素とその産物による腫瘍悪性化機序(Cancer progression by an enzyme expression under serum starvation and hypoxia)

竹中克也, 小森由香子, 中村圭靖, 小井詰史朗, 宮城洋平

日本癌学会総会記事, 78回 P-1330, Sep, 2019 Peer-reviewedLead author
Ectopic synthesis of CD69 is important for intra-peritoneal survival of ovarian clear cell carcinoma cells

Shiro Koizume, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Katsuya Takenaka, Etsuko Miyagi, Yohei Miyagi

CANCER SCIENCE, 109 667-667, Dec, 2018 Peer-reviewed
Expression of an ATP-grasp superfamily enzyme under hypoxia

Katsuya Takenaka, Yukako Komori, Yoshiyasu Nakamura, Shiro Koizume, Yohei Miyagi

CANCER SCIENCE, 109 1386-1386, Dec, 2018 Peer-reviewedLead author
異所性CD69発現は卵巣明細胞がん細胞の腹腔内生存に重要である(Ectopic synthesis of CD69 is important for intra-peritoneal survival of ovarian clear cell carcinoma cells)

小井詰史朗, 中村圭靖, 吉原光代, 竹中克也, 宮城悦子, 宮城洋平

日本癌学会総会記事, 77回 1148-1148, Sep, 2018
低酸素で発現誘導されるATP-graspスーパーファミリー酵素(Expression of an ATP-grasp superfamily enzyme under hypoxia)

竹中克也, 小森由香子, 中村圭靖, 小井詰史朗, 宮城洋平

日本癌学会総会記事, 77回 2217-2217, Sep, 2018 Peer-reviewedLead author
画像認識技術による中心体解析とその複製制御に関与するBRCA2分子内領域の同定(Specification of BRCA2 domain for centrosomal regulation using image recognition)

佐藤玄, 倉科太一, 紺野真衣, 三木義男, 竹中克也

日本癌学会総会記事, 73回 P-3082, Sep, 2014 Peer-reviewedLast authorCorresponding author
中心体複製制御における乳癌原因遺伝子BRCA2とその結合分子の役割(Function of BRCA2 and its associating proteins in centrosomal regulation)

手代木翔太, 三木義男, 竹中克也

日本癌学会総会記事, 72回 282-282, Oct, 2013 Peer-reviewedLast authorCorresponding author
乳がん生物学における新たな治療標的がん抑制タンパクBRCA2の新規細胞機能の解析(New insights into the cellular function of BRCA2)

三木義男, 竹中克也, 中西啓

日本癌学会総会記事, 70回 276-277, Sep, 2011
BRCA2とnucleophosminによる中心体数の維持とROCK2との相互作用(BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with ROCK2)

竹中克也, 王慧峰, 中西啓, 三木義男

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回 3P-0476, Dec, 2010 Peer-reviewedLead author
ゲノム上点変異導入によるPolκ活性中心変異株の作製と解析

竹中克也, 三木義男

生化学, 82回 ROMBUNNO.3P-587-587, Sep 25, 2009 Peer-reviewedLead author
新規BRCA2結合タンパク質BJ-HCC-20AはDNA損傷に応答したアポトーシス誘導を抑制する(Novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage)

冨吉郷, 中西啓, 竹中克也, 吉田清嗣, 三木義男

日本癌学会総会記事, 67回 145-145, Sep, 2008
Critical role for Pol zeta in cellular tolerance to nitric oxide-induced DNA damage

XH Wu, K Takenaka, E Sonoda, H Hochegger, S Kawanishi, T Kawamoto, S Takeda, M Yamazoe

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 14(11) 2688S-2688S, Nov, 2005
ゴルジ体のトポバイオジェネシス研究セミインタクト細胞系とGFPを用いたアプローチ

村田昌之, 加納ふみ, 竹中克也, 永山国昭, 山本章嗣, 西田栄介

日本分子生物学会年会プログラム・講演要旨集, 22nd 222, Nov 22, 1999
細胞周期依存的ゴルジ体小胞化におけるcdc2とMEKの関与セミインタクトMDCK細胞を用いた研究

加納ふみ, 竹中克也, 永山国昭, 西田栄介, 村田昌之

日本細胞生物学会大会講演要旨集, 52nd 75, 1999
Mechanisms of the cell cycle-dependent morphogenesis of the Golgi apparatus in semi-intact MDCK cells

KANO Fumi, TAKENAKA Katsuya, NAGAYAMA Kuniaki, NISHIDA Eisuke, MURATA Masayuki

日本分子生物学会年会プログラム・講演要旨集, 21 485-485, Dec 1, 1998
セミインタクトMDCK細胞を用いた細胞周期依存的ゴルジ体の形態形成機構

加納ふみ, 竹中克也, 永山国昭, 西田栄介, 村田昌之

日本分子生物学会年会プログラム・講演要旨集, 21st 485, Nov, 1998
Activation of p38 in the Spindle Assembly Checkpoint and Induction of the Mitotic Arrest.

竹中克也, 森口徹生, 西田栄介

日本分子生物学会年会プログラム・講演要旨集, 20th 433, Dec, 1997
Activation of p38 in the Spindle Asembly Checkpoint and Induction of the Mitotic Arrest.

竹中克也, 森口徹生, 西田栄介

日本分子生物学会年会プログラム・講演要旨集, 20th 223, Dec, 1997
Functions of MAP Kinase in Cell Cycle Regulation.

竹中克也, 後藤由季子, 西田栄介

細胞周期制御のネットワーク平成5-7年度, 5-12, 1996

Teaching Experience

Professional Memberships

THE JAPANESE CANCER ASSOCIATION

Research Projects

ＤＮＡ修復と中心体複製異常を指標にしたＢＲＣＡの分子間相互作用責任部位の特定

科学研究費補助金基盤研究（Ｃ）, 日本学術振興会, Apr, 2015 - Mar, 2019

竹中克也
Functional analysis of BRCA genes and searching for molecular partner for synthetic lethality.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

MIKI Yoshio, NAKANISHI Akira, TAKENAKA Katsuya
乳癌原因遺伝子ＢＲＣＡ２新規結合分子が中心体複製及びＤＮＡ修復に果たす役割の解明

科学研究費補助金基盤研究（Ｃ）, 日本学術振興会, Apr, 2011 - Mar, 2014

竹中克也
乳癌原因遺伝子ＢＲＣＡ２新規結合タンパク質が発癌過程に関与する機構の解明

2012年度医学系研究奨励, 公益財団法人武田科学振興財団, 2012 - 2012

竹中克也
乳癌原因遺伝子ＢＲＣＡに結合する新規分子の探索とゲノム変異導入による細胞機能解明

科学研究費補助金若手研究（Ｂ）, 日本学術振興会, Apr, 2009 - Mar, 2011

竹中克也
Analysis of Homologous DNA Recombination using the chicken DT40 B cell line

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2005 - 2006

TAKEDA Shunichi
初期胚卵割及び体細胞分裂におけるMAPキナーゼ系の役割

科学研究費助成事業, 特別研究員奨励費, 日本学術振興会, 1998 - 1998

竹中克也

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