takeshi iwatsubo

J-GLOBAL         Last updated: Dec 16, 2018 at 15:13
 
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Name
takeshi iwatsubo

Published Papers

 
LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.
Eguchi T, Kuwahara T, Sakurai M, Komori T, Fujimoto T, Ito G, Yoshimura SI, Harada A, Fukuda M, Koike M, Iwatsubo T
Proc Natl Acad Sci USA   115 E9115-E9124   2018   [Refereed]
Japanese and North American Alzheimer’s Disease Neuroimaging Initiative studies: harmonization for international trials.
Iwatsubo T, Iwata A, Suzuki K, Ihara R, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H, Sun CK, Beckett LA, Petersen RC, Weiner MW, Aisen PS, Donohue MC
Alzheimers Dementia   14 1077-1087   2018   [Refereed]
Chronic optogenetic activation augments Aβ pathology in a mouse model of Alzheimer disease.
Yamamoto K, Tanei Z, Hashimoto T, Wakabayashi T, Okuno H, Naka Y, Yizhar O, Fenno LE, Fukayama M, Bito H, Cirrito JR, Holtzman DM, Deisseroth K, Iwatsubo T
Cell Reports   11 859-865   2015   [Refereed]
Phase three trials of solanezumab for mild to moderate Alzheimer’s disease.
Doody RS, Thomas RG, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, Raman R, Sun X, Aisen PS et al.
N Eng J Med   370 311-321   2014   [Refereed]
CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development.
Tanaka T, Wakabayashi T, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T
J Neurosci   34 1370-1379   2014   [Refereed]
A phase 3 trial of semagacestat for treatment of Alzheimer’s disease.
Doody RS, Raman R, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, He F, Sun X, Thomas RG, Aisen PS et al.
N Engl J Med   369 341-350   2013   [Refereed]
Activity-dependent proteolytic cleavage of neuroligin-1.
Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zheng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, Koyama R, Tomita T, Iwatsubo T
Neuron   76 410-422   2012   [Refereed]
Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1.
Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T
EMBO Journal   30 4815-4824   2011   [Refereed]
Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.
Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR Jr, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH
Alzheimers Dementia   7 280-292   2011   [Refereed]
Cheung KH, Mei L, Mak DO, Hayashi I, Iwatsubo T, Kang DE, Foskett JK
Science signaling   3 ra22   Mar 2010   [Refereed]
Masuda S, Kumano K, Suzuki T, Tomita T, Iwatsubo T, Natsugari H, Tojo A, Shibutani M, Mitsumori K, Hanazono Y, Ogawa S, Kurokawa M, Chiba S
Cancer science   100(12) 2444-2450   Dec 2009   [Refereed]
Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T
Bioorganic & medicinal chemistry letters   19(24) 6869-6871   Dec 2009   [Refereed]
Kamikawaji S, Ito G, Iwatsubo T
Biochemistry   48(46) 10963-10975   Nov 2009   [Refereed]
Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T
The Journal of biological chemistry   284(41) 27838-27847   Oct 2009   [Refereed]
Yamada K, Yabuki C, Seubert P, Schenk D, Hori Y, Ohtsuki S, Terasaki T, Hashimoto T, Iwatsubo T
The Journal of neuroscience : the official journal of the Society for Neuroscience   29 11393-11398   Sep 2009   [Refereed]
Saha S, Guillily MD, Ferree A, Lanceta J, Chan D, Ghosh J, Hsu CH, Segal L, Raghavan K, Matsumoto K, Hisamoto N, Kuwahara T, Iwatsubo T, Moore L, Goldstein L, Cookson M, Wolozin B
The Journal of neuroscience : the official journal of the Society for Neuroscience   29 9210-9218   Jul 2009   [Refereed]
Shimizu N, Watanabe H, Kubota J, Wu J, Saito R, Yokoi T, Era T, Iwatsubo T, Watanabe T, Nishina S, Azuma N, Katada T, Nishina H
Biological & pharmaceutical bulletin   32(6) 999-1003   Jun 2009   [Refereed]
Imamura Y, Watanabe N, Umezawa N, Iwatsubo T, Kato N, Tomita T, Higuchi T
Journal of the American Chemical Society   131(21) 7353-7359   Jun 2009   [Refereed]
Azeredo da Silveira S, Schneider BL, Cifuentes-Diaz C, Sage D, Abbas-Terki T, Iwatsubo T, Unser M, Aebischer P
Human molecular genetics   18 872-887   Mar 2009   [Refereed]
Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, Thinakaran G
The Journal of biological chemistry   284(3) 1373-1384   Jan 2009   [Refereed]