論文

国際誌
2019年12月2日

Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood.

Nutrients
  • Yuki Higuchi
  • ,
  • Michihiro Hosojima
  • ,
  • Hideyuki Kabasawa
  • ,
  • Shoji Kuwahara
  • ,
  • Sawako Goto
  • ,
  • Koji Toba
  • ,
  • Ryohei Kaseda
  • ,
  • Takahiro Tanaka
  • ,
  • Nobutaka Kitamura
  • ,
  • Hayato Takihara
  • ,
  • Shujiro Okuda
  • ,
  • Masayuki Taniguchi
  • ,
  • Hitoshi Arao
  • ,
  • Ichiei Narita
  • ,
  • Akihiko Saito

11
12
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/nu11122919

Obesity and related disorders, which are increasing in adults worldwide, are closely linked to childhood diet and are associated with chronic inflammation. Rice endosperm protein (REP) intake during adulthood has been reported to improve lipid metabolism and suppress the progression of diabetic kidney disease in animal models. However, the effects of REP intake during childhood on adulthood health are unclear. Therefore, we used a mouse model to experimentally investigate the preconditioning effects of REP intake during childhood on the development of obesity and related disorders in adulthood. Male C57BL/6J mice were pair-fed a normal-fat diet containing casein or REP during the juvenile period and then a high-fat diet (HFD) containing casein or REP during adulthood. Mice fed REP during the juvenile period showed better body weight, blood pressure, serum lipid profiles, lipopolysaccharide (LPS)-binding protein levels, and glucose tolerance in adulthood than those fed casein during the juvenile period. HFD-induced renal tubulo-glomerular alterations and hepatic microvesicular steatosis were less evident in REP-fed mice than in casein-fed ones. REP intake during the juvenile period improved HFD-induced dysbiosis (i.e., Escherichia genus proliferation and reduced gut microbiota diversity), thereby suppressing endotoxin-related chronic inflammation. Indeed, REP-derived peptides showed antibacterial activity against Escherichia coli, a major producer of LPS. In conclusion, REP supplementation during the juvenile period may regulate the gut microbiota and thus suppress the development of obesity and related disorders in adulthood in mice.

リンク情報
DOI
https://doi.org/10.3390/nu11122919
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31810329
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950226
ID情報
  • DOI : 10.3390/nu11122919
  • PubMed ID : 31810329
  • PubMed Central 記事ID : PMC6950226

エクスポート
BibTeX RIS