Papers

2020

Rapid measurement of plasma concentration of a molecular-targeted agent, pazopanib, with diamond sensor.

Proceedings for Annual Meeting of The Japanese Pharmacological Society
  • Takuro Saiki
  • Ogata Genki
  • Kato Rito
  • Razvina Olga
  • Sawamura Seishiro
  • Matsumoto Yoshifumi
  • Hanawa Ai
  • Asai Kai
  • Einaga Yasuaki
  • Saijo Yasuo
  • Hibino Hiroshi
  • Display all

Volume
93
Number
First page
1-YIA-18
Last page
Language
Japanese
Publishing type
DOI
10.1254/jpssuppl.93.0_1-yia-18
Publisher
Japanese Pharmacological Society

Molecular-targeted anticancer drugs elicit less toxicity than conventional reagents. Yet, patients often suffer from severe adverse effects. A reason is 'fixed dosage' administration of the drug to all the patients regardless of their body size and complications; because of this strategy, the plasma concentration seems to exceed the therapeutic window occasionally. Although frequent measurement of the drug level at a clinical site is a solution, currently available methods such as mass spectrometry are time and cost consuming. To overcome these shortcomings, in this study, we developed a procedure with an electrochemical sensor composed of a conductive diamond, which yields more stable reactions than conventional materials. When guinea-pig plasma mixed with pazopanib, a multi-kinase inhibitor, was tested, the sensor detected a clinically relevant concentration of 3 to 300 µM. Time and sample amount necessary for each series of the measurement was <1 min and 100 µL, respectively. The sensor was repeatedly usable with minimal impairment of the sensitivity, saving the cost for the assay. This rapid and easily-handed method may enable therapeutic drug monitoring and accelerate tailored medicine for cancer.

Link information
DOI
https://doi.org/10.1254/jpssuppl.93.0_1-yia-18
CiNii Research
https://cir.nii.ac.jp/crid/1390565134836762240?lang=en
URL
https://www.jstage.jst.go.jp/article/jpssuppl/93/0/93_1-YIA-18/_pdf
URL
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K16442/
ID information
  • DOI : 10.1254/jpssuppl.93.0_1-yia-18
  • eISSN : 2435-4953
  • CiNii Articles ID : 130007811478
  • CiNii Research ID : 1390565134836762240

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