2009年12月
Molecular Chaperone BiP Interacts with Borna Disease Virus Glycoprotein at the Cell Surface
JOURNAL OF VIROLOGY
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- 巻
- 83
- 号
- 23
- 開始ページ
- 12622
- 終了ページ
- 12625
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1128/JVI.01201-09
- 出版者・発行元
- AMER SOC MICROBIOLOGY
Borna disease virus (BDV) is characterized by highly neurotropic infection. BDV enters its target cells using virus surface glycoprotein (G), but the cellular molecules mediating this process remain to be elucidated. We demonstrate here that the N-terminal product of G, GP1, interacts with the 78-kDa chaperone protein BiP. BiP was found at the surface of BDV-permissive cells, and anti-BiP antibody reduced BDV infection as well as GP1 binding to the cell surface. We also reveal that BiP localizes at the synapse of neurons. These results indicate that BiP may participate in the cell surface association of BDV.
- リンク情報
- ID情報
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- DOI : 10.1128/JVI.01201-09
- ISSN : 0022-538X
- PubMed ID : 19776128
- Web of Science ID : WOS:000271465600060