論文

査読有り
2017年6月

Differential regulations of vestibulo-ocular reflex and optokinetic response by beta- and alpha 2-adrenergic receptors in the cerebellar flocculus

SCIENTIFIC REPORTS
  • Ryo Wakita
  • ,
  • Soshi Tanabe
  • ,
  • Kazunari Tabei
  • ,
  • Asako Funaki
  • ,
  • Takuma Inoshita
  • ,
  • Tomoo Hirano

7
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-017-04273-9
出版者・発行元
NATURE PUBLISHING GROUP

Norepinephrine modulates synaptic plasticity in various brain regions and is implicated in memory formation, consolidation and retrieval. The cerebellum is involved in motor learning, and adaptations of the vestibulo-ocular reflex (VOR) and optokinetic response (OKR) have been studied as models of cerebellum-dependent motor learning. Previous studies showed the involvement of adrenergic systems in the regulation of VOR, OKR and cerebellar synaptic functions. Here, we show differential contributions of beta- and alpha 2-adrenergic receptors in the mouse cerebellar flocculus to VOR and OKR control. Effects of application of beta- or alpha 2-adrenergic agonist or antagonist into the flocculus suggest that the beta-adrenergic receptor activity maintains the VOR gain at high levels and contributes to adaptation of OKR, and that alpha 2-adrenergic receptor counteracts the beta-receptor activity in VOR and OKR control. We also examined effects of norepinephrine application, and the results suggest that norepinephrine regulates VOR and OKR through beta-adrenergic receptor at low concentrations and through alpha 2-receptor at high concentrations.

リンク情報
DOI
https://doi.org/10.1038/s41598-017-04273-9
ID情報
  • DOI : 10.1038/s41598-017-04273-9

エクスポート
BibTeX RIS