論文

査読有り 国際誌
2018年3月27日

Occurrence of long-term depression in the cerebellar flocculus during adaptation of optokinetic response.

eLife
  • Takuma Inoshita
  • ,
  • Tomoo Hirano

7
記述言語
英語
掲載種別
DOI
10.7554/eLife.36209

Long-term depression (LTD) at parallel fiber (PF) to Purkinje cell (PC) synapses has been considered as a main cellular mechanism for motor learning. However, the necessity of LTD for motor learning was challenged by demonstration of normal motor learning in the LTD-defective animals. Here, we addressed possible involvement of LTD in motor learning by examining whether LTD occurs during motor learning in the wild-type mice. As a model of motor learning, adaptation of optokinetic response (OKR) was used. OKR is a type of reflex eye movement to suppress blur of visual image during animal motion. OKR shows adaptive change during continuous optokinetic stimulation, which is regulated by the cerebellar flocculus. After OKR adaptation, amplitudes of quantal excitatory postsynaptic currents at PF-PC synapses were decreased, and induction of LTD was suppressed in the flocculus. These results suggest that LTD occurs at PF-PC synapses during OKR adaptation.

リンク情報
DOI
https://doi.org/10.7554/eLife.36209
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29582755
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871328
ID情報
  • DOI : 10.7554/eLife.36209
  • PubMed ID : 29582755
  • PubMed Central 記事ID : PMC5871328

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