論文

査読有り 国際誌
2020年6月2日

Norepinephrine facilitates induction of long-term depression through β-adrenergic receptor at parallel fiber-to-Purkinje cell synapses in the flocculus.

Neuroscience
  • Takuma Inoshita
  • ,
  • Tomoo Hirano

記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neuroscience.2020.05.037

The cerebellum is involved in motor learning, and long-term depression (LTD) at parallel fiber-to-Purkinje cell (PF-PC) synapses has been considered to be a primary cellular mechanism for motor learning. In addition, the contribution of norepinephrine (NE) to cerebellum-dependent learning paradigms has been reported. Thus, the roles of LTD and of NE in motor learning have been studied separately, and the relationship between the effects of NE and LTD remains unclear. Here, we examined effects of β-adrenergic receptor (β-AR) activity on the synaptic transmission and LTD at PF-PC synapses in the cerebellar flocculus. The flocculus regulates adaptation of oculomotor reflexes, and we previously reported the involvement of both LTD and β-AR in adaptation of an oculomotor reflex in the flocculus. Here we found that specific agonists for β-AR or NE did not directly change synaptic transmission, but lowered the threshold for LTD induction at PF-PC synapses in the flocculus. In addition, protein kinase A (PKA), which is activated downstream of β-AR, facilitated the LTD induction. Altogether, these results suggest that NE facilitates LTD induction at PF-PC synapses in the flocculus by activating PKA through β-AR.

リンク情報
DOI
https://doi.org/10.1016/j.neuroscience.2020.05.037
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32502572
ID情報
  • DOI : 10.1016/j.neuroscience.2020.05.037
  • PubMed ID : 32502572

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