Takumi NARITA

Profile Information

Affiliation: Clinical Research Support Center, Mie University Hospital

J-GLOBAL ID: 201901016117269212
researchmap Member ID: B000362321

Research Interests

Research Areas

Life sciences / Environmental and pharmaceutical development resources /

Research History

Apr, 2023 - Present

Section Chief, Division of Health and Clinical Data, Department of Health and Clinical Data, Japan Agency for Medical Research and Development
Oct, 2022 - Present

Clinical Research Support Center, Mie University Hospital
Nov, 2022 - Mar, 2023

Section Chief, Division of Genomic Medicine, Department of Health and Clinical Data, Japan Agency for Medical Research and Development
Jul, 2020 - Sep, 2022

Graduate School of Medical Science, Kyoto Prefectural University of Medicine
Apr, 2018 - Jun, 2020

特任研究員, 社会と健康研究センター予防研究部, 国立研究開発法人国立がん研究センター
Apr, 2015 - Mar, 2018

Research Institute for Science and Technology, Organization for Research Advancement, Tokyo University of Science

Awards

Sep, 2018

ベストポスター賞, 平成30年度先端モデル動物支援若手支援技術講習会

成田匠

Papers

Induction of MYCN-amplified neuroblastoma differentiation through NMYC suppression using PPAR-γ antagonist.

Yukako Nakao-Ise, Takumi Narita, Shingo Miyamoto, Motoki Watanabe, Takuji Tanaka, Yoshihiro Sowa, Yosuke Iizumi, Mitsuharu Masuda, Gen Fujii, Yasuko Hirai …

Journal of clinical biochemistry and nutrition, 73(3) 191-197, Nov, 2023
Citrus limon L.-Derived Nanovesicles Show an Inhibitory Effect on Cell Growth in p53-Inactivated Colorectal Cancer Cells via the Macropinocytosis Pathway

Hideki Takakura, Toshimasa Nakao, Takumi Narita, Mano Horinaka, Yukako Nakao-Ise, Tetsushi Yamamoto, Yosuke Iizumi, Motoki Watanabe, Yoshihiro Sowa, Keisuke Oda …

Biomedicines, 10(6) 1352-1352, Jun 8, 2022 Peer-reviewed
新規食品成分としての植物由来エクソソーム様ナノ粒子による大腸がん予防効果の可能性

高倉英樹, 小田啓祐, 中尾俊雅, 成田匠, 堀中真野, 中尾由佳子, 山本哲志, 飯泉陽介, 渡邉元樹, 曽和義広 …

日本薬学会年会要旨集, 142年会 26PO10-01, Mar, 2022
Induction of DNA Damage in Mouse Colorectum by Administration of Colibactin-producing Escherichia coli, Isolated from a Patient With Colorectal Cancer

TAKUMI NARITA, YUTA TSUNEMATSU, NORIYUKI MIYOSHI, MASAMI KOMIYA, TAKAHIRO HAMOYA, GEN FUJII, YUKO YOSHIKAWA, MICHIO SATO, MASANOBU KAWANISHI, HARUHIKO SUGIMURA …

In Vivo, 36(2) 628-634, 2022 Peer-reviewed
Sodium salicylate and 5-aminosalicylic acid synergistically inhibit the growth of human colon cancer cells and mouse intestinal polyp-derived cells

Hideki Takakura, Mano Horinaka, Ayaka Imai, Yuichi Aono, Toshimasa Nakao, Shingo Miyamoto, Yosuke Iizumi, Motoki Watanabe, Takumi Narita, Hideki Ishikawa …

Journal of Clinical Biochemistry and Nutrition, 70(2) 93-102, 2022 Peer-reviewed
[Not Available].

Midori Morita, Mahiro Iizuka-Ohashi, Motoki Watanabe, Takumi Narita, Chikage Kato, Daichi Kakibuchi, Fuyuki Kitano, Yoshimi Ouchi, Koichi Sakaguchi, Tetsuya Taguchi

Journal of clinical biochemistry and nutrition, 68(3) 235-242, May, 2021
Oxidative stress induces EGFR inhibition-related skin cell death.

Midori Morita, Mahiro Iizuka-Ohashi, Motoki Watanabe, Chikage Kato, Takumi Narita, Daichi Kakibuchi, Fuyuki Kitano, Yoshimi Ouchi, Koichi Sakaguchi, Tetsuya Taguchi

Journal of clinical biochemistry and nutrition, 68(3) 235-242, Mar 25, 2021 Peer-reviewed
Artesunate inhibits intestinal tumorigenesis through inhibiting wnt signaling

Takahiro Hamoya, Gen Fujii, Yosuke Iizumi, Takumi Narita, Masami Komiya, Yui Matsuzawa, Kohei Miki, Tadashi Kondo, Shinji Kishimoto, Kenji Watanabe …

Carcinogenesis, 42(1) 148-158, Feb 11, 2021 Peer-reviewed
Complex Modulating Effects of Dietary Calcium Intake on Obese Mice

MAIKO TAKAHASHI, TAKAHIRO HAMOYA, TAKUMI NARITA, GEN FUJII, YUKARI TOTSUKA, MASAHITO HAGIO, KOSUKE TASHIRO, MASAMI KOMIYA, MICHIHIRO MUTOH

In Vivo, 35(4) 2107-2114, 2021 Peer-reviewed
Theracurmin inhibits intestinal polyp development in Apc-mutant mice by inhibiting inflammation-related factors.

Saeko Adachi, Takahiro Hamoya, Gen Fujii, Takumi Narita, Masami Komiya, Shingo Miyamoto, Yurie Kurokawa, Maiko Takahashi, Tetsuji Takayama, Hideki Ishikawa …

Cancer science, 111(4) 1367-1374, Apr, 2020 Peer-reviewed
The Radical Scavenger NZ-419 Suppresses Intestinal Polyp Development in Apc-Mutant Mice.

Yurie Kurokawa, Gen Fujii, Susumu Tomono, Shingo Miyamoto, Takahiro Hamoya, Maiko Takahashi, Takumi Narita, Masami Komiya, Masaki Kobayashi, Yoshikazu Higami …

Journal of clinical medicine, 9(1), Jan 18, 2020 Peer-reviewed
Activation of NF-E2 p45-related factor-2 transcription and inhibition of intestinal tumor development by AHCC, a standardized extract of cultured Lentinula edodes mycelia.

Maiko Takahashi, Gen Fujii, Takahiro Hamoya, Yurie Kurokawa, Yui Matsuzawa, Kohei Miki, Masami Komiya, Takumi Narita, Michihiro Mutoh

Journal of clinical biochemistry and nutrition, 65(3) 203-208, Nov, 2019 Peer-reviewed
Novel screening system revealed that intracellular cholesterol trafficking can be a good target for colon cancer prevention.

Shingo Miyamoto, Takumi Narita, Masami Komiya, Gen Fujii, Takahiro Hamoya, Ruri Nakanishi, Shuya Tamura, Yurie Kurokawa, Maiko Takahashi, Michihiro Mutoh

Scientific reports, 9(1) 6192-6192, Apr 17, 2019 Peer-reviewed
Inhibition of NF-kappaB transcriptional activity enhances fucoxanthinol-induced apoptosis in colorectal cancer cells.

Shuya Tamura, Takumi Narita, Gen Fujii, Shingo Miyamoto, Takahiro Hamoya, Yurie Kurokawa, Maiko Takahashi, Kouhei Miki, Yui Matsuzawa, Masami Komiya …

Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 41 1-1, 2019 Peer-reviewedLead author
SREBP-1c-Dependent Metabolic Remodeling of White Adipose Tissue by Caloric Restriction.

Masaki Kobayashi, Namiki Fujii, Takumi Narita, Yoshikazu Higami

International journal of molecular sciences, 19(11) 3335, Oct 26, 2018 Peer-reviewed
Differential response to caloric restriction of retroperitoneal, epididymal, and subcutaneous adipose tissue depots in rats.

Takumi Narita, Masaki Kobayashi, Kaho Itakura, Rei Itagawa, Riho Kabaya, Yuka Sudo, Naoyuki Okita, Yoshikazu Higami

Experimental gerontology, 104 127-137, Apr, 2018 Peer-reviewedLead author
Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction.

Masaki Kobayashi, Kanae Takeda, Takumi Narita, Keita Nagai, Naoyuki Okita, Yuka Sudo, Yuri Miura, Hiroki Tsumoto, Yoshimi Nakagawa, Hitoshi Shimano …

FEBS letters, 591(24) 4067-4073, Dec, 2017 Peer-reviewed
Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction.

Namiki Fujii, Takumi Narita, Naoyuki Okita, Masaki Kobayashi, Yurika Furuta, Yoshikazu Chujo, Masahiro Sakai, Atsushi Yamada, Kanae Takeda, Tomokazu Konishi …

Aging cell, 16(3) 508-517, Jun, 2017 Peer-reviewedLead author
Chronological analysis of caloric restriction-induced alteration of fatty acid biosynthesis in white adipose tissue of rats.

Naoyuki Okita, Takuro Tsuchiya, Mayumi Fukushima, Kaho Itakura, Keiko Yuguchi, Takumi Narita, Yukari Hashizume, Yuka Sudo, Takuya Chiba, Isao Shimokawa …

Experimental gerontology, 63 59-66, Mar, 2015 Peer-reviewed
Caloric restriction-associated remodeling of rat white adipose tissue: effects on the growth hormone/insulin-like growth factor-1 axis, sterol regulatory element binding protein-1, and macrophage infiltration.

Yoshikazu Chujo, Namiki Fujii, Naoyuki Okita, Tomokazu Konishi, Takumi Narita, Atsushi Yamada, Yushi Haruyama, Kosuke Tashiro, Takuya Chiba, Isao Shimokawa …

Age (Dordrecht, Netherlands), 35(4) 1143-56, Aug, 2013 Peer-reviewed

Misc.

History and Current Topics of Aspirin as a Colorectal Cancer Chemopreventive Agent

武藤倫弘, 成田匠, 藤井元

京都府立医科大学雑誌, 129(7) 469-477, 2020

Books and Other Publications

特集老化と栄養 : 老化制御と長寿をめぐる医療最前線

成田匠, 宮本真吾, 武藤倫弘 (Role: Contributor, 抗酸化制御能を有する食品成分による老化制御)

講談社エディトリアル,講談社 (発売), Aug, 2022 (ISBN: 9784065289945)
Lynch syndrome : molecular mechanism and current clinical practice

Tomita, Naohiro (Role: Contributor, Capture 12. Chemoprevention for Lynch Syndrome-Associated Malignancies)

Springer, 2020 (ISBN: 9789811568909)

Presentations

Minマウスのポリープ発達における脾腫の影響

成田匠, 高山英次, 中尾俊雅, 宮本真吾, 武藤倫弘

第35回発癌病理研究会, Nov 29, 2022
Prevention of intestinal polyps by Brassicaceae plants

Takumi NARITA, Gen Fujii, Mitsuharu MASUDA, Yoshihiro SOWA, Shingo MIYAMOTO, Motoki WATANABE, Yosuke IIZUMI, Michihiro MUTOH

Jul 27, 2022
Effect of AHCC® on immunity in a familial adenomatous polyposis mouse model

Takumi Narita, Eiji Takayama, Michihiro Mutoh

The 30th Annual Meeting of International Congress on Nutrition and Integrative Medicine, Jul 9, 2022
脾腫が腸ポリープ生成に与える影響（第二報）

成田匠, 中尾俊雅, 増田光治, 曽和義広, 渡邉元樹, 飯泉陽介, 宮本真吾, 武藤倫弘

第２９回日本がん予防学会学術大会, Jul 1, 2022
Sulforapheneによる抗酸化を介した大腸がん予防

成田匠, 曽和義広, 渡邉元樹, 飯泉陽介, 増田光治, 武藤倫弘

第４０回Cytoprotection研究会, Mar 25, 2022
Deactivation of glutaminolysis sensitizes PIK3CA-mutated colorectal cancer cells to aspirin-induced growth inhibition

Shogen Boku, Motoki Watanabe, Maagiro Iizuka-Ohashi, Yoshihiro Sowa, Mitsuharu Masuda, Takumi Narita, Toshiyuki Sakai, Michihiro Mutoh
脾腫が腸ポリープ生成に与える影響

成田匠, 中尾俊雅, 曽和義広, 渡邉元樹, 飯泉陽介, 増田光治, 武藤倫弘

第28回日本がん予防学会総会, Sep 10, 2021
ケモプロテオミクスおよび分子動力学シミュレーションが明らかにした、延命草の苦味成分ラブドシアノンIの標的タンパク質と抗腫瘍メカニズム

渡邉元樹, 山田恭正, 来見田遥一, 亀田倫史, 助野真美子, 飯塚まひろ, 曽和義広, 飯泉陽介, 高倉英樹, 宮本真吾, 増田光治, 成田匠, 酒井敏行, 武藤倫弘

日本電気泳動学会第72回総会
抗酸化制御能を有する食品成分による老化制御（がん予防や脂質代謝異常改善）

成田匠, 樋上賀一, 武藤倫弘

第21回日本抗加齢医学会総会, Jun 26, 2021 Invited
Analysis of adipocyte-specific mitochondrial intermediate peptidase (MIPEP) knockout mice 〜The possibility as a novel mitochondrial stress model〜

Masaki KOBAYASHI, Takumi NARITA, Yoshikazu HIGAMI

Jun 12, 2021
Prevention of geriatric diseases using Brassicaceae

Takumi NARITA, Takahiro HAMOYA, Gen FUJII, Michihiro MUTOH

Jun 12, 2021
細胞外グルタミン濃度はがん予防薬の感受性に影響する

渡邉元樹, 朴将源, 宮本景子, 曽和義広, 飯泉陽介, 増田光治, 成田匠, 中尾俊雅, 武藤倫弘, 酒井敏行

第91回日本衛生学会学術総会
Combinatorial treatments of aspirin with glutaminolysis-targeting agents against PIK3CA-mutated colorectal cancer cells

SHOGEN BOKU, Motoki Watanabe, Mamiko Sukeno, Takeshi Yaoi, Kiichi Hirota, Mahiro Iizuka, Kyoko Itoh, Yoshihiro Sowa, Yosuke Iizumi, Mitsuharu Masuda, Takumi Narita, Takahiro Hamoya, Toshiyuki Sakai, Michihiro Mutoh
xCT inhibition increases sensitivity to vorinostat in a ROS-dependent manner

Motoki Watanabe, Keiko Miyamoto, Shogen Boku, Koichi Sakaguchi, Tetsuya Taguchi, Yoshihiro Sowa, Yosuke Iizumi, Mitsuharu Masuda, Takumi Narita, Takahiro Hamoya, Toshiyuki Sakai, Michihiro Mutoh

第79回日本癌学会学術総会
Elucidation of Wnt signaling suppression mechanism by artesunate in human colorectal cancer cells.

Takahiro Hamoya, Gen Fujii, Yosuke Iizumi, Masami Komiya, Takumi Narita, Yoshihiro Sowa, Motoki Watanabe, Mitsuharu Masuda, Michihiro Mutoh
Analysis of chemopreventive effects of Sulforaphene on colon carcinogenesis

Takumi Narita, Takahiro Hamoya, Gen Fujii, Masami Komiya, Yoshihiro Sowa, Motoki Watanabe, Yosuke Iizumi, Mitsuharu Masuda, Michihiro Mutoh
Dual regulation of thymidylate synthase by the natural product rabdosianone I-binding proteins ANT2 and PHB2

Motoki Watanabe, Yasumasa Yamada, Yoichi Kurumida, Tomoshi Kameda, Yoshihiro Sowa, Mahiro Iizuka-Ohashi, Mamiko Sukeno, Yosuke Iizumi, Mitsuharu Masuda, Takumi Narita, Takahiro Hamoya, Toshiyuki Sakai, Michihiro Mutoh
ケモプロテオーム解析および分子動力学シミュレーションによる延命草の苦味成分rabdosianone Iの標的同定および抗腫瘍効果の機序解明

渡邉元樹, 山田恭正, 来見田遥一, 亀田倫史, 助野真美子, 飯塚まひろ, 曽和義広, 飯泉陽介, 増田光治, 中尾俊雅, 鱧屋隆博, 成田匠, 酒井敏行, 武藤倫弘

がん予防学術大会2020米子, Sep 15, 2020
インドキノキ由来Resveratrolによる腸発がん抑制効果の検討とそのメカニズムの解明

松澤優衣, 和田浩典, 藤井元, 中西るり, 小宮雅美, 成田匠, 鱧屋隆博, 三木洸平, 照屋貴宏, 十島二朗, 高山哲治, 武藤倫弘

がん予防学術大会2020米子, Sep 15, 2020
高脂肪食摂取によるメチル化が腸発がん過程に与える影響の解析

三木洸平, 藤井元, 中西るり, 小宮雅美, 成田匠, 鱧屋隆博, 松澤優衣, 照屋貴宏, 十島二朗, 武藤倫弘

がん予防学術大会2020米子, Sep 15, 2020

Research Projects

Search / identification of foods and food components that have a preventive effect on colorectal cancer and elucidation of the mechanism

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Narita Takumi

Industrial Property Rights

WO/2022/176917 MESENCHYMAL STEM CELLS AND ADIPOCYTES FOR PREPARING MITOKINE MIXTURE, AND THERAPEUTIC OR PROPHYLACTIC DRUG

HIGAMI Yoshikazu, KOBAYASHI Masaki, NARITA Takumi, TAKI Kanari, HIRAO Yuto
WO2020/013271 SCREENING METHOD FOR ANTI-OBESITY SUBSTANCE, AND KIT FOR SCREENING FOR ANTI-OBESITY SUBSTANCE

HIGAMI Yoshikazu, KOBAYASHI Masaki, NARITA Takumi, TAKI Kanari

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