恒川卓 (Taku Tsunekawa) - マイポータル

基本情報

所属: 名古屋大学医学部附属病院糖尿病・内分泌内科助教

学位: 博士（医学）(名古屋大学)

研究者番号: 10809825
J-GLOBAL ID: 201801018004639000
researchmap会員ID: B000337623

研究キーワード

研究分野

ライフサイエンス / 代謝、内分泌学 /

経歴

2018年4月 - 現在

名古屋大学, 医学部附属病院糖尿病・内分泌内科, 助教
2017年4月 - 2018年3月

名古屋大学, 医学部附属病院糖尿病・内分泌内科, 病院助教

学歴

- 2017年4月

名古屋大学, 医学系研究科
- 2007年3月

名古屋大学, 医学部, 医学科

論文

GABAB Receptor Signaling in the Mesolimbic System Suppresses Binge-like Consumption of a High-Fat Diet.

Tsunekawa T, Banno R, Yaginuma H, Taki K, Mizoguchi A, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Ito Y …

iScience 20 337-347-347 2019年9月26日
Improved methods for the differentiation of hypothalamic vasopressin neurons using mouse induced pluripotent stem cells.

Mitsumoto K, Suga H, Sakakibara M, Soen M, Yamada T, Ozaki H, Nagai T, Kano M, Kasai T, Ozone C …

Stem cell research 40 101572-101572 2019年9月6日
Tanycyte-Like Cells Derived From Mouse Embryonic Stem Culture Show Hypothalamic Neural Stem/Progenitor Cell Functions.

Kano M, Suga H, Ishihara T, Sakakibara M, Soen M, Yamada T, Ozaki H, Mitsumoto K, Kasai T, Sugiyama M …

Endocrinology 160(7) 1701-1718-1718 2019年7月1日査読有り
Chemical chaperone 4-phenylbutylate reduces mutant protein accumulation in the endoplasmic reticulum of arginine vasopressin neurons in a mouse model for familial neurohypophysial diabetes insipidus

Tochiya Masayoshi, Hagiwara Daisuke, Azuma Yoshinori, Miyata Takashi, Morishita Yoshiaki, Suga Hidetaka, Onoue Takeshi, Tsunekawa Taku, Takagi Hiroshi, Ito Yoshihiro …

Neuroscience letters (682) 50-55 2018年8月24日査読有り
Patients with anti-thyroid antibodies are prone to develop destructive thyroiditis by nivolumab: a prospective study

Tomoko Kobayashi, Shintaro Iwama, Yoshinori Yasuda, Norio Okada, Taku Tsunekawa, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Yoshiaki Morishita …

Journal of the Endocrine Society 2(3) 241-251 2018年2月6日査読有り
Sequestosome 1 (SQSTM1/p62) maintains protein folding capacity under endoplasmic reticulum stress in mouse hypothalamic organotypic culture.

Tominaga T, Goto M, Onoue T, Mizoguchi A, Sugiyama M, Tsunekawa T, Hagiwara D, Morishita Y, Ito Y, Iwama S …

Neuroscience Letter 656 103-107 2017年8月24日査読有り
PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions.

Sugiyama M, Banno R, Mizoguchi A, Tominaga T, Tsunekawa T, Onoue T, Hagiwara D, Ito Y, Morishita Y, Iwama S …

Biochemical and Biophysical Research Communications 488(1) 116-121 2017年6月17日査読有り
Deficiency of PTP1B Attenuates Hypotalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia.

Tsunekawa T, Banno R, Mizoguchi A, Sugiyama M, Tominaga T, Onoue T, Hagiwara D, Ito Y, Iwama S, Goto M …

EBioMedicine 16 172-183 2017年2月16日査読有り
AgRP Neuron-Specific Deletion of Glucocorticoid Receptor Leads to Increased Energy Expenditure and Decreased Body Weight in Female Mice on a High-Fat

Miyuki Shibata, Ryoichi Banno, Mariko Sugiyama, Takashi Tominaga, Takeshi Onoue, Taku Tsunekawa, Yoshinori Azuma, Daisuke Hagiwara, Wenjun Lu, Yoshihiro Ito …

ENDOCRINOLOGY 157(4) 1457-1466 2016年4月査読有り
Reactive oxygen species mediate insulin signal transduction in mouse hypothalamus.

Onoue T, Goto M, Tominaga T, Sugiyama M, Tsunekawa T, Hagiwara D, Banno R, Suga H, Sugimura Y, Arima H

Neuroscience Letter 619 1-7 2016年査読有り
Mitogen-activated protein kinase phosphatase 1 negatively regulates MAPK signaling in mouse hypothalamus.

Adachi K, Goto M, Onoue T, Tsunekawa T, Shibata M, Hagimoto S, Ito Y, Banno R, Suga H, Sugimura Y …

Neuroscience Letter 569 49-54 2014年5月21日査読有り
Susceptibility-weighted imaging（SWI）を含む画像経過を観察しえた糖尿病性舞踏病の1例

恒川卓, 吉岡修子, 杉山摩利子, 篠原由里, 西尾勇一郎, 佐藤郁子, 佐藤豊大, 湯浅浩之

糖尿病 57(4) 249-255 2014年4月査読有り
Urine output and resultant osmotic water shift are major determinants of plasma sodium level in syndrome of inappropriate antidiuretic hormone secretion.

Okumura A, Ishikawa K, Watanabe R, Tsunekawa T, Asai C, Kiyota A, Watanabe M, Oiso Y

Translational Research 162(1) 56-63 2013年査読有り

MISC

Chemical chaperone 4-phenylbutylate reduces mutant protein accumulation in the endoplasmic reticulum of arginine vasopressin neurons in a mouse model for familial neurohypophysial diabetes insipidus

Masayoshi Tochiya, Daisuke Hagiwara, Yoshinori Azuma, Takashi Miyata, Yoshiaki Morishita, Hidetaka Suga, Takeshi Onoue, Taku Tsunekawa, Hiroshi Takagi, Yoshihiro Ito …

Neuroscience Letters 682 50-55 2018年8月24日
Chemical chaperone 4-phenylbutylate reduces mutant protein accumulation in the endoplasmic reticulum of arginine vasopressin neurons in a mouse model for familial neurohypophysial diabetes insipidus

Tochiya Masayoshi, Hagiwara Daisuke, Azuma Yoshinori, Miyata Takashi, Morishita Yoshiaki, Suga Hidetaka, Onoue Takeshi, Tsunekawa Taku, Takagi Hiroshi, Ito Yoshihiro …

Neuroscience letters (682) 50-55 2018年8月24日査読有り
Patients with anti-thyroid antibodies are prone to develop destructive thyroiditis by nivolumab: a prospective study

Tomoko Kobayashi, Shintaro Iwama, Yoshinori Yasuda, Norio Okada, Taku Tsunekawa, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Yoshiaki Morishita …

Journal of the Endocrine Society 2(3) 241-251 2018年2月6日査読有り
Sequestosome 1 (SQSTM1/p62) maintains protein folding capacity under endoplasmic reticulum stress in mouse hypothalamic organotypic culture.

Tominaga T, Goto M, Onoue T, Mizoguchi A, Sugiyama M, Tsunekawa T, Hagiwara D, Morishita Y, Ito Y, Iwama S …

Neuroscience Letter 656 103-107 2017年8月24日査読有り
PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions.

Sugiyama M, Banno R, Mizoguchi A, Tominaga T, Tsunekawa T, Onoue T, Hagiwara D, Ito Y, Morishita Y, Iwama S …

Biochemical and Biophysical Research Communications 488(1) 116-121 2017年6月17日査読有り
Deficiency of PTP1B Attenuates Hypotalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia.

Tsunekawa T, Banno R, Mizoguchi A, Sugiyama M, Tominaga T, Onoue T, Hagiwara D, Ito Y, Iwama S, Goto M …

EBioMedicine 16 172-183 2017年2月16日査読有り
AgRP Neuron-Specific Deletion of Glucocorticoid Receptor Leads to Increased Energy Expenditure and Decreased Body Weight in Female Mice on a High-Fat

Miyuki Shibata, Ryoichi Banno, Mariko Sugiyama, Takashi Tominaga, Takeshi Onoue, Taku Tsunekawa, Yoshinori Azuma, Daisuke Hagiwara, Wenjun Lu, Yoshihiro Ito …

ENDOCRINOLOGY 157(4) 1457-1466 2016年4月査読有り
Reactive oxygen species mediate insulin signal transduction in mouse hypothalamus.

Onoue T, Goto M, Tominaga T, Sugiyama M, Tsunekawa T, Hagiwara D, Banno R, Suga H, Sugimura Y, Arima H

Neuroscience Letter 619 1-7 2016年査読有り
Mitogen-activated protein kinase phosphatase 1 negatively regulates MAPK signaling in mouse hypothalamus.

Adachi K, Goto M, Onoue T, Tsunekawa T, Shibata M, Hagimoto S, Ito Y, Banno R, Suga H, Sugimura Y …

Neuroscience Letter 569 49-54 2014年5月21日査読有り
Susceptibility-weighted imaging（SWI）を含む画像経過を観察しえた糖尿病性舞踏病の1例

恒川卓, 吉岡修子, 杉山摩利子, 篠原由里, 西尾勇一郎, 佐藤郁子, 佐藤豊大, 湯浅浩之

糖尿病 57(4) 249-255 2014年4月査読有り
Urine output and resultant osmotic water shift are major determinants of plasma sodium level in syndrome of inappropriate antidiuretic hormone secretion.

Okumura A, Ishikawa K, Watanabe R, Tsunekawa T, Asai C, Kiyota A, Watanabe M, Oiso Y

Translational Research 162(1) 56-63 2013年査読有り

講演・口頭発表等

GABAB receptor signaling in dopaminergic or striatal neurons suppresses food intake during intermittent access to a high fat diet in mice

T. TSUNEKAWA, R. BANNO, H. YAGINUMA, K. TAKI, A. MIZOGUCHI, M. SUGIYAMA, H. TAKAGI, Y. ITO, H. ARIMA

Neuroscience2018 2018年11月
PTP1B deficiency enhances leptin action to improve glucose homeostasis in IDDM.

Y ITO, R. BANNO, H. YAGINUMA, K. TAKI, A. MIZOGUCHI, M. SUGIYAMA, T. TSUNEKAWA, H. TAKAGI, H. ARIMA

Neuroscience2018 2018年11月
Mice lacking PTP1B in astrocyte protect against obesity induced by a

Sugiyama M, Banno R, Yaginuma H, Taki T, Mizoguchi A, Tsunekawa T, Takagi H, Ito Y, Yamanaka K, Arima H

Neuroscience2018 2018年11月
High-fat feeding causes microglial activation and inflammation in ventral tegmental area in mice.

Mizoguchi A, Banno R, Yaginuma H, Taki K, Sugiyama M, Tsunekawa T, Takagi H, Ito Y, Arima H

Neuroscience2018 2018年11月
Analysis of roles of glial cell subtypes in hypothalamic inflammation induced by a high fat diet

Sugiyama M, Banno R, Taki K, Mizoguchi A, Tsunekawa T, Takagi H, Ito Y, Komine O, Yamanaka K, Arima H

2017 Obesity Week 2017年11月
Baclofen suppresses food intake during scheduled feeding on a high fat diet in mice

Tsunekawa T, Banno R, Sugiyama M, Taki K, Mizoguchi A, Takagi H, Ito Y, Arima H

2017 Obesity Week 2017年11月
PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression with insulin treatment.

Sugiyama M, Banno R, Mizoguchi A, Tominaga T, Onoue T, Tsunekawa T, Ito Y, Goto M, Arima H

The Obesity Society's 2016 Annual Meeting 2016年10月
Deficiency of PTP1B attenuates hypothalamic inflammation induced by high fat diet via the activation of JAK2-STAT3 signaling pathway in the microglial cells

Tsunekawa T, Banno R, Mizoguchi A, Sugiyama M, Tominaga T, Onoue T, Ito Y, Goto M, Arima H

The Obesity Society's 2016 Annual Meeting 2016年10月
Deficiency of PTP1B attenuates hypothalamic inflammation via the activation of Jak2-Stat3 signaling pathway in the microglial cells under high fat diet conditions

Tsunekawa T, Banno R, Sugiyama M, Tominaga T, Onoue T, Goto M, Arima H

Neuroscience 2015 2015年10月
Deficiency of PTP1B attenuates hypothalamic inflammation via the activation of Jak2-Stat3 signaling pathway in the microglial cells under high fat diet conditions.

Banno R, Sugiyama M, Tominaga T, Tsunekawa T, Onoue T, Goto M, Arima H

Keystone Symposia 2015 2015年10月
AgRP neuron-specific deletion of glucocorticoid receptor leads to decreased body weight and adiposity in mice.

Shibata M, Banno R, Onoue T, Tsunekawa T, Adachi K, Ito Y, Goto M, Arima H, Oiso Y

The joint meeting of International Congress of Endocrinology and Endocrine Society (ICE/ENDO 2014) 2014年

所属学協会

共同研究・競争的資金等の研究課題

高脂肪食摂取による報酬系の炎症に着目した過食と肥満の機序解明

日本学術振興会科学研究費助成事業若手研究 2018年4月 - 2021年3月