Takuya HIKIMA

J-GLOBAL         Last updated: Dec 23, 2019 at 02:10
 
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Name
Takuya HIKIMA
E-mail
Takuya.Hikimanyulangone.org
Affiliation
New York Unversity
Section
Neurosurgery
Job title
Instructor
Degree
Ph.D.(Life science)

Profile

Instructor (Junior Faculty)
New York University School of medicine, Neurosurgery

I have been studying the source and molecular mechanisms of somatodendritic dopamine release. Dopamine neurons in substantia nigra compacta (SNc) and ventral tegmental area release dopamine not only axon but also soma and dendrites, modulating the firing patterns of themselves (Somatodendritic dopamine release). In addition, dopamine neurons regulate the activity of GABAergic neurons in substantia nigra pars reticulata (SNr) by somatodendritic dopamine release. Studying the dopamine release helps us contribute the therapy of movement and psychiatric disorder.

Research Areas

 
 

Academic & Professional Experience

 
Nov 2018
 - 
Today
Instructor, Neurosurgery, New York University School of Medicine
 
Jan 2015
 - 
Oct 2018
Research Associate Scientist, Neurosurgery, New York University School of Medicine
 
Apr 2009
 - 
Dec 2014
Researcher (postdoctoral fellow), Okinawa institute of science and technology graduate university
 

Education

 
Apr 2004
 - 
Mar 2009
Life Science, Tohoku University of Graduate school
 

Awards & Honors

 
May 2016
Detection of somatodendritic dopamine release using whole-cell recording, Best presentation Award, 16th Conference of the International Society for Monitoring Molecules in Neuroscience
 
May 2010
Japanese Physiological Sciences Award (JPS Award),, the Physiological Society of Japan
Winner: Takuya Hikima
 
Jul 2008
ANS/IBRO Travel Award, IBRO
Winner: Takuya Hikima
 
Apr 2004
Japan Scholarship Foundation Scholarship for Graduate Students, Japan Student Service Organization (JASSO)
 

Published Papers

 
Mobeen Farooq, Seonil Kim, Sunny Patel, Latika Khatri, Takuya Hikima, Margaret E. Rice, Edward B. Ziff
Neuropharmacology   113 426-433   Jun 2017   [Refereed]
Lithium (Li+) is a drug widely employed for treating bipolar disorder, however the mechanism of action is not known. Here we study the effects of Li+ in cultured hippocampal neurons on a synaptic complex consisting of δ-catenin, a protein associat...
Takuya HIKIMA
Brain research   1639 74-87   Feb 2016   [Refereed]
The aim of this work was to study release of glutamic acid (GLU) from one-axon terminal or bouton at-a-time using cortical neurons grown in vitro to study the effect of presynaptic auto- and heteroreceptor stimulation. Neurons were infected with r...
Wang H‚Sugiyama Y‚Hikima T‚Sugano E‚Tomita H‚Takahashi T‚Ishizuka T‚Yawo H
J Biol Chem   284(9) 5685-5696   2009   [Refereed]
3. Sugiyama Y‚ Wang H‚ Hikima T‚Sato M‚Takahashi T‚Kuroda J‚Ishizuka T‚Yawo H
Photochem Photobiol Sci   8 328-336   2009   [Refereed]
Hikima T‚Araki R‚Ishizuka T‚Yawo H
J Physiol Sci   59(4) 263-274   2009   [Refereed]
Suyama S*‚Hikima T*‚Sakagami H‚Ishizuka T‚Yawo H *Both authors contributed equally to this work
Neuroscience Research   59(4) 481-490   2007   [Refereed]
6. Araki R‚Sakagami H‚Yanagawa Y‚Hikima T‚Ishizuka T‚Yawo H
Genesis   4 53-60   2005   [Refereed]

Conference Activities & Talks

 
somatodendritic dopamine release
Takuya HIKIMA
NYU Neuroscience Meeting, New York, USA   Dec 2019   
Evaluation of synaptotagmin7 in the unique properties of somatodendritic dopamine release
Takuya HIKIMA, ‚ Witkovsky P, Ichtchenko K, Rice ME
Center for Cognitive Neurology (Annual Research Day)   Sep 2019   
Evaluation of synaptotagmin7 function in the unique properties of somatodendritic dopamine release
Takuya HIKIMA, Witkovsky P, Ichtchenko K, Rice ME
The 42th Annual Meeting of the Japan Neuroscience Society   Jul 2019   
Evaluation of synaptotagmin7 function in the unique properties of somatodendritic dopamine release
Hikima T‚ Witkovsky P, Ichtchenko K, Rice ME
12th Annual retreat NYU Neuroscience, New York, USA   4 Apr 2019   
M. Mancini, Takuya HIKIMA, D. Stone, P. Witkovsky, M. Rice
IBAGS 2019   Apr 2019   
Cross-talk between metabolic hormones and midbrain dopamine (DA) neurons is increasingly well-appreciated. The adipose-tissue derived hormone leptin has been demonstrated to play a role in regulating DA synthesis and somatodendritic DA stores in v...
T. Hikima, P Witkovsky, K. Ichtchenko, M. Rice
IBAGS 2019   Apr 2019   
Midbrain dopamine (DA) neurons in the substantia nigra pars compacta (SNc) exhibit somatodendritic release of DA. Released DA acts at D2 autoreceptors to regulate neuronal firing patterns that regulate DA release throughout the brain. We reported ...
Physiological role of somatodendritic dopamine release: true auto regulation of neural activity
Takuya H, Ichtchenko K、Rice ME
The 41th Annual Meeting of the Japan Neuroscience Society, Kobe Japan   Aug 2018   
Physiological role of somatodendritic dopamine release: true auto regulation of neural activity
Hikima T, Witkovsky P, Ichtchenko K, Rice ME
Gordon Research Seminar on Basal Ganglia, Ventura, USA   Mar 2018   
Physiological role of somatodendritic dopamine release: true autoregulation of neural activity
Hikima T‚ Lee CR, Ichtchenko K, Rice ME
The 94th Annual Meeting of the Physiological Society of Japan   30 Mar 2017   
Detection of somatodendritic dopamine release using whole-cell recording
Hikima T‚ Lee CR, Vazquez-Cintron, EJ, Ichtchenko K, Rice ME
16th Conference of the International Society for Monitoring Molecules in Neuroscience, Gothenburg, Sweden   May 2016   

Social Contribution

 
Marlene and Paolo Fresco I nstitute for Par kinson’s and Movem ent ,
[Informant, Planner, Organizing Member]  Marlene and Paolo Fresco Foundation  Dec 2016
OIST science talk ( high school students)
[TV or radio appearance, Informant]  OIST  Sep 2014
OIST educational course to children
[TV or radio appearance, Advisor, Informant, Planner, Organizing Member]  OIST educational course to children  Jul 2014
OIST science talk ( high school students)
[TV or radio appearance]  OIST  Jul 2014
OIST Open campus
[TV or radio appearance, Advisor, Informant, Planner, Organizing Member, Demonstrator]  OIST  Oct 2009