論文

2019年5月

A MEMS-based measurement system for evaluating the force-length relationship of human induced pluripotent stem cell-derived cardiomyocytes adhered on a substrate

JOURNAL OF MICROMECHANICS AND MICROENGINEERING
  • Kenei Matsudaira
  • ,
  • Hidetoshi Takahashi
  • ,
  • Kayoko Hirayama-Shoji
  • ,
  • Thanh-Vinh Nguyen
  • ,
  • Takuya Tsukagoshi
  • ,
  • Isao Shimoyama

29
5
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1088/1361-6439/ab093d
出版者・発行元
IOP PUBLISHING LTD

This paper reports on a method for evaluating the force-length relationship of adhering human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) on the substrate using a measurement system comprising of a micromachined movable plate and a piezoresistive force probe. The cells on the plate are stretched by pushing the movable plate with the piezoresistive cantilever, which is actuated by a piezo stage. The twitch forces and the applied stretch are measured quantitatively with the piezoresistive cantilever. The results demonstrated that the twitch forces of the hiPSC-CMs increased when a stretch was applied. This evaluation method improves the understanding of the intrinsic force-length relationship of hiPSC-CMs at the cellular scale.

Web of Science ® 被引用回数 : 4

リンク情報
DOI
https://doi.org/10.1088/1361-6439/ab093d
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000461813600001&DestApp=WOS_CPL

エクスポート
BibTeX RIS