2016年3月
Analyses of a satiety factor NUCB2/nesfatin-1; gene expressions and modulation by different dietary components in dogs
JOURNAL OF VETERINARY MEDICAL SCIENCE
- 巻
- 78
- 号
- 3
- 開始ページ
- 411
- 終了ページ
- 417
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1292/jvms.15-0255
- 出版者・発行元
- JAPAN SOC VET SCI
Nesfatin-1 is an anorexic peptide derived from a predursor, nucleobindin-2 (NUCB2), which is distributed in various organs, coexists with ghrelin in the gastric X/A-like cells and closely relates to an appetite control in rodents and humans. Nesfatin-1 may be a significant factor addressing the satiety also in veterinary medicine, however, there are few reports about nesfatin-1 in dogs. In the present study, we detected canine NUCB2/nesfatin-1 mRNA in various tissues, especially abundant in pancreas, gastrointestinal tracts, testis and cerebellum. We examined circulating nesfatin-1 concentrations and NUCB2/nesfatin-1 mRNA expressions in upper gastrointestinal tracts (gastric corpus, pyloric antrum and duodenum) in dogs fed on different types of diets. Plasma nesfatin-1 concentrations in the dogs were approximately 4 ng/ml and they did not change after feeding through the study, however, NUCB2/nesfatin-1 mRNA expressions in pyloric antrum were 1.84-fold higher in the dogs fed on a High fiber/High protein diet (P<0.001), 1.48-fold higher in the dogs fed on a High fat/Low protein diet (P<0.05) and 1.02-fold higher in the dogs fed on a Low fat/High carbohydrate diet (not significant) comparing to those on a control diet. It was concluded that High fiber/High protein and High fat/Low protein diets increased NUCB2/nesfatin-1 production in canine gastrointestinal tracts. These results may set the stage for further investigations of canine NUCB2/nesfatin-1, which may relate to satiety effects in dogs.
- リンク情報
-
- DOI
- https://doi.org/10.1292/jvms.15-0255
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201602227550915856
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/26596634
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000373248500008&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1292/jvms.15-0255
- ISSN : 0916-7250
- eISSN : 1347-7439
- J-Global ID : 201602227550915856
- PubMed ID : 26596634
- Web of Science ID : WOS:000373248500008